Detailed information for compound 1408630

Basic information

Technical information
  • TDR Targets ID: 1408630
  • Name: (5-oxo-2-propan-2-yl-[1,3,4]thiadiazolo[3,2-a ]pyrimidin-7-yl)methyl 3,4,5-trimethoxybenzoa te
  • MW: 419.452 | Formula: C19H21N3O6S
  • H donors: 0 H acceptors: 2 LogP: 2.54 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)OCc1cc(=O)n2c(n1)sc(n2)C(C)C
  • InChi: 1S/C19H21N3O6S/c1-10(2)17-21-22-15(23)8-12(20-19(22)29-17)9-28-18(24)11-6-13(25-3)16(27-5)14(7-11)26-4/h6-8,10H,9H2,1-5H3
  • InChiKey: PMXAQTCFRGJSDR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2-isopropyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl 3,4,5-trimethoxybenzoate
  • 3,4,5-trimethoxybenzoic acid (2-isopropyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • 3,4,5-trimethoxybenzoic acid (2-isopropyl-5-keto-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • G265-0106
  • NCGC00129984-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0158 0.0722 0.0973
Trypanosoma cruzi cysteine peptidase, putative 0.03 0.267 0.4054
Loa Loa (eye worm) hypothetical protein 0.0209 0.142 0.2077
Trypanosoma cruzi cruzipain precursor, putative 0.0187 0.1116 0.1596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Trypanosoma cruzi cysteine peptidase, putative 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0387 0.3866 0.5946
Echinococcus granulosus cathepsin b 0.0404 0.4096 0.4032
Echinococcus multilocularis endothelin converting enzyme 1 0.0209 0.142 0.1327
Loa Loa (eye worm) fibroinase 0.0573 0.6429 1
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Loa Loa (eye worm) hypothetical protein 0.0187 0.1116 0.1596
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.03 0.267 0.267
Loa Loa (eye worm) hypothetical protein 0.0158 0.0722 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Onchocerca volvulus 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0672 0.0894
Leishmania major cysteine peptidase A (CPA) 0.0573 0.6429 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0573 0.6429 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0113 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Loa Loa (eye worm) ctsf protein 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0722 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0722 0.0973
Brugia malayi Cathepsin L-like cysteine proteinase 0.0387 0.3866 0.5946
Loa Loa (eye worm) hypothetical protein 0.0209 0.142 0.2077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0404 0.4096 0.631
Echinococcus multilocularis cathepsin b 0.0404 0.4096 0.4032
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0209 0.142 0.142
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0573 0.6429 1
Giardia lamblia Cathepsin B precursor 0.0203 0.1341 1
Entamoeba histolytica cysteine proteinase, putative 0.03 0.267 0.4054
Toxoplasma gondii cathepsin B 0.0203 0.1341 0.1952
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0573 0.6429 1
Onchocerca volvulus Cathepsin F homolog 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.1116 0.1596
Entamoeba histolytica cysteine protease, putative 0.0573 0.6429 1
Toxoplasma gondii peptidase family M13 protein 0.0209 0.142 0.2077
Giardia lamblia Cathepsin B precursor 0.0203 0.1341 1
Giardia lamblia Cathepsin B precursor 0.0203 0.1341 1
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0209 0.142 0.5
Echinococcus multilocularis cysteine protease 0.0573 0.6429 0.639
Onchocerca volvulus 0.0573 0.6429 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.03 0.267 0.267
Brugia malayi Cathepsin L-like precursor 0.0573 0.6429 1
Trypanosoma cruzi cysteine peptidase, putative 0.0573 0.6429 1
Onchocerca volvulus 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.03 0.267 0.4054
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Entamoeba histolytica cysteine proteinase 2 0.03 0.267 0.4054
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Echinococcus granulosus cathepsin l1 0.0573 0.6429 0.639
Entamoeba histolytica cysteine proteinase, putative 0.03 0.267 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0672 0.0894
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Brugia malayi Cathepsin L-like precursor 0.0573 0.6429 1
Brugia malayi MH2 domain containing protein 0.0144 0.0534 0.0674
Loa Loa (eye worm) hypothetical protein 0.0387 0.3866 0.5946
Echinococcus multilocularis cathepsin L cysteine protease 0.0573 0.6429 0.639
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0113 0.0107 0.0107
Echinococcus granulosus cathepsin L 0.03 0.267 0.2591
Brugia malayi Papain family cysteine protease containing protein 0.03 0.267 0.4054
Echinococcus granulosus cysteine protease 0.03 0.267 0.2591
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Schistosoma mansoni cathepsin S (C01 family) 0.0113 0.0107 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Onchocerca volvulus Cathepsin L homolog 0.0573 0.6429 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0387 0.3866 0.5946
Loa Loa (eye worm) hypothetical protein 0.0158 0.0722 0.0973
Trypanosoma cruzi cysteine proteinase, putative 0.03 0.267 0.4054
Loa Loa (eye worm) hypothetical protein 0.0387 0.3866 0.5946
Loa Loa (eye worm) hypothetical protein 0.0209 0.142 0.2077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.3866 0.5946
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0203 0.1341 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Brugia malayi Cathepsin L-like precursor 0.0573 0.6429 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Loa Loa (eye worm) cathepsin B 0.0203 0.1341 0.1952
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0404 0.4096 0.631
Brugia malayi Cathepsin L-like precursor 0.0187 0.1116 0.1596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Echinococcus multilocularis cysteine protease 0.0573 0.6429 0.639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.03 0.267 0.4054
Loa Loa (eye worm) hypothetical protein 0.0154 0.0672 0.0894
Echinococcus granulosus cathepsin l1 0.0387 0.3866 0.38
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0573 0.6429 0.639
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0573 0.6429 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0187 0.1116 0.1596
Entamoeba histolytica cysteine proteinase, putative 0.0387 0.3866 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Brugia malayi cathepsin L-like precursor 0.0387 0.3866 0.5946
Trypanosoma cruzi cysteine protease, putative 0.03 0.267 0.4054
Plasmodium vivax vivapain-1 0.03 0.267 0.4054
Onchocerca volvulus 0.0387 0.3866 0.5946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0113 0.0107 0.0107
Brugia malayi Cathepsin L-like precursor 0.0387 0.3866 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.03 0.267 0.2612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Trypanosoma cruzi cysteine peptidase, putative 0.0187 0.1116 0.1596
Echinococcus granulosus cathepsin L cysteine protease 0.03 0.267 0.2591
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0722 0.0973
Echinococcus multilocularis cathepsin L cysteine protease 0.0573 0.6429 0.639
Brugia malayi Papain family cysteine protease containing protein 0.0573 0.6429 1
Brugia malayi Peptidase family M13 containing protein 0.0209 0.142 0.2077
Schistosoma mansoni cathepsin B (C01 family) 0.0113 0.0107 0.0107
Brugia malayi Cathepsin L-like precursor 0.0573 0.6429 1
Trypanosoma cruzi cysteine peptidase, putative 0.0573 0.6429 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.03 0.267 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0573 0.6429 0.639
Trypanosoma cruzi cysteine proteinase, putative 0.03 0.267 0.4054
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0534 0.0674
Plasmodium vivax unspecified product 0.0187 0.1116 0.1596
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0404 0.4096 0.4096
Loa Loa (eye worm) hypothetical protein 0.0187 0.1116 0.1596
Brugia malayi Cathepsin L-like precursor 0.0573 0.6429 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.03 0.267 0.267
Loa Loa (eye worm) cysteine protease 0.0573 0.6429 1
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Schistosoma mansoni cathepsin C 0.0113 0.0107 0.0107
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.03 0.267 0.4054
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0534 0.0674
Entamoeba histolytica cysteine proteinase, putative 0.0573 0.6429 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0573 0.6429 0.639
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0209 0.142 0.2077
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Schistosoma mansoni cathepsin F (C01 family) 0.0573 0.6429 0.6429
Toxoplasma gondii cathepsin CPL 0.0573 0.6429 1
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0113 0.0107 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0187 0.1116 0.1596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Echinococcus multilocularis cathepsin L 0.03 0.267 0.2591
Onchocerca volvulus 0.0573 0.6429 1
Plasmodium vivax vivapain-2 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.3866 0.5946
Plasmodium vivax unspecified product 0.03 0.267 0.4054
Loa Loa (eye worm) hypothetical protein 0.0154 0.0672 0.0894
Loa Loa (eye worm) hypothetical protein 0.0573 0.6429 1
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0113 0.0107 0.0107
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Entamoeba histolytica cysteine proteinase, putative 0.03 0.267 0.4054
Brugia malayi Cathepsin L-like precursor 0.0387 0.3866 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0113 0.0107 0.0107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0113 0.0107 0.0107
Mycobacterium leprae probable zinc metalloprotease 0.0209 0.142 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Plasmodium vivax vivapain-2 0.0573 0.6429 1
Schistosoma mansoni cathepsin s 0.0187 0.1116 0.1116
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0187 0.1116 0.1596
Entamoeba histolytica cysteine proteinase, putative 0.03 0.267 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Brugia malayi Cathepsin L-like precursor 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.03 0.267 0.2612
Loa Loa (eye worm) peptidase family M13 containing protein 0.0154 0.0672 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0573 0.6429 1
Onchocerca volvulus 0.0573 0.6429 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0573 0.6429 0.639
Schistosoma mansoni cathepsin F (C01 family) 0.0573 0.6429 0.6429
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0113 0.0107 0.0107
Onchocerca volvulus 0.0573 0.6429 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Trypanosoma cruzi cysteine peptidase, putative 0.0573 0.6429 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0404 0.4096 0.4096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0573 0.6429 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0404 0.4096 0.4096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0573 0.6429 1
Entamoeba histolytica cysteine proteinase 1, putative 0.03 0.267 0.4054
Brugia malayi cathepsin B-like cysteine proteinase 0.0404 0.4096 0.631
Onchocerca volvulus 0.0573 0.6429 1
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.0154 0.0672 0.0894
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0203 0.1341 0.1341
Leishmania major cathepsin L-like protease 0.0573 0.6429 1
Plasmodium vivax vivapain-3 0.03 0.267 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0573 0.6429 1
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1
Echinococcus granulosus cathepsin b 0.0404 0.4096 0.4032
Entamoeba histolytica cysteine proteinase, putative 0.0573 0.6429 1
Schistosoma mansoni cathepsin F (C01 family) 0.0387 0.3866 0.3866
Mycobacterium ulcerans zinc metalloprotease 0.0209 0.142 0.5
Onchocerca volvulus Cathepsin L homolog 0.0573 0.6429 1
Echinococcus granulosus endothelin converting enzyme 1 0.0209 0.142 0.1327
Trypanosoma cruzi cruzipain precursor, putative 0.0573 0.6429 1
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0203 0.1341 0.1952
Echinococcus multilocularis cathepsin b 0.0404 0.4096 0.4032
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0113 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.03 0.267 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.03 0.267 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0404 0.4096 0.4096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0573 0.6429 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5174 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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