Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0073 | 0.1346 | 0.1346 |
Schistosoma mansoni | kinase | 0.0056 | 0.0824 | 0.1068 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.2502 | 0.2502 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0199 | 0.5238 | 0.5238 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0073 | 0.1346 | 0.1346 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0073 | 0.1346 | 0.1346 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0199 | 0.5238 | 1 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0041 | 0.0352 | 0.0673 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0624 | 0.0624 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0849 | 0.1621 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0111 | 0.2502 | 0.4464 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.0296 | 0.0565 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0039 | 0.0296 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.4548 | 0.8684 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0199 | 0.5238 | 1 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0199 | 0.5238 | 1 |
Schistosoma mansoni | transcription factor btf3 | 0.0041 | 0.0352 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.5238 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0199 | 0.5238 | 1 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0199 | 0.5238 | 0.5238 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0199 | 0.5238 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0624 | 0.0624 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0352 | 0.0171 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0061 | 0.0959 | 0.0959 |
Onchocerca volvulus | 0.0177 | 0.4548 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0038 | 0.0268 | 0.0268 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0199 | 0.5238 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.005 | 0.0624 | 0.0624 |
Loa Loa (eye worm) | ICD-1 protein | 0.0041 | 0.0352 | 0.0673 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0199 | 0.5238 | 0.5238 |
Brugia malayi | beta-NAC-like protein | 0.0041 | 0.0352 | 0.0673 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0111 | 0.2502 | 0.2502 |
Echinococcus granulosus | transcription factor btf3 | 0.0041 | 0.0352 | 0.0114 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0199 | 0.5238 | 0.5238 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0352 | 0.0171 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.2502 | 0.4464 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0073 | 0.1346 | 0.1346 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0073 | 0.1346 | 0.1346 |
Brugia malayi | Phosphoglycerate kinase | 0.0073 | 0.1346 | 0.257 |
Brugia malayi | hypothetical protein | 0.0177 | 0.4548 | 0.8684 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0111 | 0.2502 | 0.4777 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0199 | 0.5238 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0199 | 0.5238 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0111 | 0.2502 | 0.4464 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.4253 | 0.4253 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0038 | 0.0268 | 0.0268 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0073 | 0.1346 | 0.1346 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Toxoplasma gondii | NAC domain-containing protein | 0.0041 | 0.0352 | 0.0673 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.0073 | 0.1346 | 0.1346 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0199 | 0.5238 | 0.5238 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0199 | 0.5238 | 1 |
Giardia lamblia | Phosphoglycerate kinase | 0.0199 | 0.5238 | 1 |
Treponema pallidum | phosphoglycerate kinase | 0.0199 | 0.5238 | 0.5 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0199 | 0.5238 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0199 | 0.5238 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0111 | 0.2502 | 0.4495 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0041 | 0.0352 | 0.0352 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.0779 | 0.1028 |
Trypanosoma cruzi | 3-phosphoglycerate kinase, glycosomal | 0.0073 | 0.1346 | 0.1346 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.2502 | 0.2502 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0199 | 0.5238 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0041 | 0.0352 | 0.0171 |
Echinococcus multilocularis | transcription factor btf3 | 0.0041 | 0.0352 | 0.0114 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0296 | 0.0057 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0041 | 0.0352 | 0.0673 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0038 | 0.0268 | 0.0268 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.4253 | 0.4253 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0038 | 0.0268 | 0.0268 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0111 | 0.2502 | 0.4777 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.2502 | 0.4495 |
Trypanosoma brucei | polo-like protein kinase | 0.0111 | 0.2502 | 0.2502 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0199 | 0.5238 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0199 | 0.5238 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0041 | 0.0352 | 0.0352 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0352 | 0.0171 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0199 | 0.5238 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.0779 | 0.1028 |
Leishmania major | basic transcription factor 3a, putative | 0.0041 | 0.0352 | 0.0352 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0199 | 0.5238 | 1 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0199 | 0.5238 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0624 | 0.0624 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0038 | 0.0268 | 0.0511 |
Trichomonas vaginalis | rotamase, putative | 0.0039 | 0.0296 | 0.0057 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0041 | 0.0352 | 0.0352 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0199 | 0.5238 | 0.5238 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.4253 | 0.4253 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0352 | 0.0171 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity against rat P2X4 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current by two-electrode voltage-clamp electrophysiology | ChEMBL. | 21207957 | |
Inhibition (functional) | = 106 % | Antagonist activity against rat P2X2 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current at 100 nM by two-electrode voltage-clamp electrophysiology | ChEMBL. | 21207957 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.