Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.2019 | 0.3958 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0118 | 0.5976 | 0.8837 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.2019 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.5101 | 0.5101 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.5101 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.5101 | 1 |
Onchocerca volvulus | 0.0165 | 0.8802 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.2019 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.2019 | 0.2019 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.5101 | 1 |
Leishmania major | trypanothione reductase | 0.0052 | 0.2019 | 0.3958 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.5101 | 0.4544 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.1984 | 0.389 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.2019 | 0.2985 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.5101 | 0.5101 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.5101 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.5101 | 0.5795 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.5101 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.8802 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0118 | 0.5976 | 0.8837 |
Brugia malayi | glutathione reductase | 0.0052 | 0.2019 | 0.2294 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.2019 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.1984 | 0.389 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.2019 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0118 | 0.5976 | 0.8837 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Schistosoma mansoni | kinase | 0.0053 | 0.2066 | 0.2066 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.5101 | 0.5101 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.5101 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0118 | 0.5976 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0118 | 0.5976 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0118 | 0.5976 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0131 | 0.6763 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0131 | 0.6763 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.2019 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0131 | 0.6763 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.2019 | 0.2019 |
Brugia malayi | hypothetical protein | 0.0165 | 0.8802 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0131 | 0.6763 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.2019 | 0.2294 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.5101 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.2019 | 0.3958 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 13.3 uM | Anticoagulant activity in human plasma assessed as concentration required to 1.5 prothrombin time | ChEMBL. | 21349710 |
FC (ADMET) | = 2.1 | Inhibition of CYP3A4 using BFC substrate after 25 mins by TDI experiment relative to initial IC50 | ChEMBL. | 21349710 |
Ki (binding) | = 5 nM | Inhibition of factor 10a activity measured using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrate | ChEMBL. | 21349710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.