Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.5101 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.5101 | 0.5101 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.5976 | 0.8837 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Schistosoma mansoni | kinase | 0.0051 | 0.2066 | 0.2066 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.2019 | 1 |
Brugia malayi | glutathione reductase | 0.005 | 0.2019 | 0.2294 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.5976 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.2019 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.1984 | 0.389 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.8802 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.5101 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.5976 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.2019 | 0.2294 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.2019 | 0.3958 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.6763 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.2019 | 0.2019 |
Brugia malayi | hypothetical protein | 0.016 | 0.8802 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.5976 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.2019 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.6763 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.5976 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.6763 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.6763 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.5101 | 0.5101 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.2019 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.5976 | 0.8837 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.5101 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.5101 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.2019 | 0.3958 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.5101 | 0.5795 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.2019 | 0.2985 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.5101 | 0.5101 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.5101 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.2019 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.5101 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.2019 | 0.2019 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.1984 | 0.389 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.5101 | 0.4544 |
Leishmania major | trypanothione reductase | 0.005 | 0.2019 | 0.3958 |
Onchocerca volvulus | 0.016 | 0.8802 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5101 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antimicrobial activity against Escherichia coli HS294 by broth dilution assay | ChEMBL. | 21273067 |
MIC (functional) | = 100 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 25922 by broth dilution assay | ChEMBL. | 21273067 |
MIC (functional) | > 100 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 27853 by broth dilution assay | ChEMBL. | 21273067 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.