Detailed information for compound 1504631

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.731 | Formula: C29H40N6O4S
  • H donors: 2 H acceptors: 4 LogP: 2.47 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNC(=O)Nc1sc2c(c1C(=O)N1CCN(CC1)C1CCN(CC1)C(=O)C1CCN(CC1)C(=O)C)cccc2
  • InChi: 1S/C29H40N6O4S/c1-3-30-29(39)31-26-25(23-6-4-5-7-24(23)40-26)28(38)35-18-16-33(17-19-35)22-10-14-34(15-11-22)27(37)21-8-12-32(13-9-21)20(2)36/h4-7,21-22H,3,8-19H2,1-2H3,(H2,30,31,39)
  • InChiKey: OCMGPIXKGNDYPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0693 0.3944
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0157 0.6392 0.7317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.6392 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.1252 0.2561
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0157 0.6392 0.6133
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0157 0.6392 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.4251 1
Loa Loa (eye worm) acetyltransferase 0.0156 0.6328 0.7264
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1252 0.2561
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0936 0.116
Echinococcus multilocularis musashi 0.0029 0.0669 0.1047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0219 0.0252
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.2542 0.5761
Echinococcus granulosus thyroid hormone receptor alpha 0.0074 0.2685 0.4201
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0693 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.2211 0.494
Schistosoma mansoni nuclear receptor 0.0074 0.2685 0.3995
Brugia malayi conserved hypotetical protein 0.0074 0.2685 0.3028
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.4251 1
Schistosoma mansoni retinoic acid receptor RXR 0.0157 0.6392 1
Echinococcus granulosus dna polymerase kappa 0.0064 0.2211 0.3459
Echinococcus granulosus dna polymerase eta 0.0035 0.0936 0.1464
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.3082 0.4638
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0715 0.1118
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.2127 0.4732
Brugia malayi hypothetical protein 0.0083 0.3082 0.3487
Echinococcus multilocularis nuclear receptor nhr 48 0.0074 0.2685 0.4201
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.142 0.1228
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.4251 0.488
Loa Loa (eye worm) nuclear receptor NHR-67 0.0074 0.2685 0.3083
Echinococcus multilocularis ecdysone induced protein 78C 0.0157 0.6392 1
Brugia malayi Nuclear hormone receptor E75 0.0074 0.2685 0.3028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0157 0.6392 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.6133 0.9595
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Onchocerca volvulus 0.0074 0.2685 0.2161
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.142 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0157 0.6392 1
Brugia malayi Pre-SET motif family protein 0.0209 0.871 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.4251 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.2127 0.4732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0157 0.6392 0.7338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0936 0.1074
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.4251 0.6532
Trypanosoma brucei unspecified product 0.0024 0.0451 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.2211 0.2036
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.6392 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.6392 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0693 0.4153
Brugia malayi nuclear receptor RXR 0.0074 0.2685 0.3028
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0693 0.4596
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.125 0.9979
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0219 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.2127 0.4732
Loa Loa (eye worm) steroid hormone receptor 0.0157 0.6392 0.7338
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.1208 0.1891
Echinococcus granulosus FTZ F1 alpha 0.0157 0.6392 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0157 0.6392 0.7338
Schistosoma mansoni lamin 0.0029 0.0669 0.0729
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0669 0.0768
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0083 0.3082 0.4822
Brugia malayi Steroid receptor seven-up type 2 0.0157 0.6392 0.7317
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Echinococcus multilocularis lamin 0.0029 0.0669 0.1047
Brugia malayi nuclear hormone receptor 0.0157 0.6392 0.7317
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0669 0.0768
Onchocerca volvulus 0.0157 0.6392 0.6133
Toxoplasma gondii exonuclease III APE 0.0019 0.0219 0.0346
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0669 0.0695
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.4251 0.488
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1135 0.2272
Onchocerca volvulus 0.0074 0.2685 0.2161
Loa Loa (eye worm) nuclear hormone receptor 0.0074 0.2685 0.3083
Echinococcus multilocularis dna polymerase eta 0.0035 0.0936 0.1464
Schistosoma mansoni thyroid hormone receptor 0.0157 0.6392 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.2127 0.3091
Brugia malayi polk-prov protein 0.0039 0.1135 0.1234
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0074 0.2685 0.3995
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.2542 0.3977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0157 0.6392 0.7338
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.1252 0.2561
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0219 0.0343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0074 0.2685 0.4201
Schistosoma mansoni nuclear hormone receptor 0.0157 0.6392 1
Echinococcus granulosus transcription factor Dp 1 0.0041 0.1208 0.1891
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0157 0.6392 1
Giardia lamblia DINP protein human, muc B family 0.0042 0.1252 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Trypanosoma brucei unspecified product 0.0024 0.0451 0.0576
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1895 0.4155
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0157 0.6392 1
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4251 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0936 0.1464
Echinococcus multilocularis dna polymerase kappa 0.0064 0.2211 0.3459
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Brugia malayi nuclear receptor RXR 0.0083 0.3082 0.3487
Loa Loa (eye worm) hypothetical protein 0.0039 0.1135 0.1303
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.2211 0.2036
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.2211 0.494
Brugia malayi steroid hormone receptor 0.0157 0.6392 0.7317
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0768 0.1361
Onchocerca volvulus 0.003 0.0715 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0074 0.2685 0.3995
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0157 0.6392 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0715 0.1118
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0074 0.2685 0.2161
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Schistosoma mansoni RAR-like nuclear receptor 0.0157 0.6392 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0157 0.6392 0.7317
Brugia malayi nuclear receptor NHR-88 0.0157 0.6392 0.7317
Echinococcus granulosus ecdysone induced protein 78C 0.0157 0.6392 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Schistosoma mansoni nuclear receptor nhr-48 0.0074 0.2685 0.3995
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.142 0.2222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0646 0.0741
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0083 0.3082 0.4638
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0157 0.6392 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0157 0.6392 1
Schistosoma mansoni nuclear hormone receptor 0.0074 0.2685 0.3995
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0936 0.1777
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0665 0.1041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0157 0.6392 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0157 0.6392 0.7317
Plasmodium vivax SET domain protein, putative 0.003 0.0715 0.4125
Brugia malayi tailless protein 0.0074 0.2685 0.3028
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1135 0.2272
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0219 0.0343
Trypanosoma brucei unspecified product 0.0057 0.1895 0.4155
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0157 0.6392 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0693 0.4596
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.4251 0.6532
Schistosoma mansoni thyroid hormone receptor 0.0157 0.6392 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Brugia malayi phosphofructokinase 0.0109 0.4251 0.484
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0715 0.1118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0715 0.0803
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0074 0.2685 0.4201
Brugia malayi Nuclear hormone receptor-like 1 0.0157 0.6392 0.7317
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0157 0.6392 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0693 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0768 0.1361
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0693 0.5
Schistosoma mansoni nuclear receptor 0.0074 0.2685 0.3995
Schistosoma mansoni zinc finger protein 0.0074 0.2685 0.3995
Onchocerca volvulus Protein ultraspiracle homolog 0.0157 0.6392 0.6133
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.2542 0.2862
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.6328 0.9896
Echinococcus granulosus Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Loa Loa (eye worm) phosphofructokinase 0.0109 0.4251 0.488
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.4251 0.4122
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0936 0.116
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0936 0.1777
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0157 0.6392 0.7317
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.142 1
Brugia malayi 6-phosphofructokinase 0.0109 0.4251 0.484
Echinococcus granulosus intermediate filament protein 0.0029 0.0669 0.1047
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.2127 0.4732
Brugia malayi nuclear hormone receptor family member odr-7 0.0074 0.2685 0.3028
Loa Loa (eye worm) hypothetical protein 0.003 0.0715 0.082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0157 0.6392 0.7317
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Echinococcus multilocularis FTZ F1 alpha 0.0157 0.6392 1
Brugia malayi Pre-SET motif family protein 0.003 0.0715 0.0748
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0157 0.6392 0.7317
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.2127 0.3328
Brugia malayi orphan nuclear receptor NR2E1 0.0074 0.2685 0.3028
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.4251 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0715 0.4328
Schistosoma mansoni DNA polymerase eta 0.0035 0.0936 0.116
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0074 0.2685 0.3083
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0157 0.6392 0.7317
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.4251 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.2542 0.3977
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.6392 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.142 0.1228
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.2127 0.2382
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0693 0.1175
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.3082 0.3487
Schistosoma mansoni coup transcription factor 0.0157 0.6392 1
Brugia malayi nuclear hormone receptor 0.0074 0.2685 0.3028
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0693 0.4153
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.2127 0.3328
Onchocerca volvulus Bile acid receptor homolog 0.0157 0.6392 0.6133
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.6328 0.99
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.2542 0.5761
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0936 0.1074
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4251 1
Brugia malayi ecdysone receptor 0.0074 0.2685 0.3028
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0083 0.3082 0.3539
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0157 0.6392 0.7317
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.2542 0.2918
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.125 0.2556
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0693 0.4586
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0219 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0157 0.6392 0.7317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0715 0.0803
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.2211 0.494
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.2542 0.5761
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0157 0.6392 1
Brugia malayi intermediate filament protein 0.0029 0.0669 0.0695
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0157 0.6392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0768 0.1361
Brugia malayi hypothetical protein 0.0083 0.3082 0.3487
Brugia malayi hypothetical protein 0.0074 0.2685 0.3028
Echinococcus multilocularis lamin dm0 0.0029 0.0669 0.1047
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0936 0.1003
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1942 0.223
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0715 0.0803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0157 0.6392 0.7338
Loa Loa (eye worm) DR-78 0.0074 0.2685 0.3083
Echinococcus granulosus nuclear receptor nhr 48 0.0074 0.2685 0.4201
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Schistosoma mansoni steroid hormone receptor ad4bp 0.0157 0.6392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Schistosoma mansoni lamin 0.0029 0.0669 0.0729
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0936 0.1777
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.871 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0083 0.3082 0.4822
Leishmania major DNA polymerase eta, putative 0.0035 0.0936 0.1777
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0936 0.1003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0157 0.6392 0.7317
Schistosoma mansoni intermediate filament proteins 0.0029 0.0669 0.0729
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0074 0.2685 0.4201
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0069 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.3082 0.3487
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Echinococcus granulosus lamin dm0 0.0029 0.0669 0.1047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0936 0.1777
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Brugia malayi photoreceptor-specific nuclear receptor 0.0157 0.6392 0.7317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.6392 1
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.2211 0.494
Leishmania major DNA polymerase kappa, putative 0.0042 0.1252 0.2561
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0157 0.6392 0.7338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2211 0.494
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0157 0.6392 0.7338
Brugia malayi hypothetical protein 0.0074 0.2685 0.3028
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.125 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0157 0.6392 0.7317
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0157 0.6392 0.7317
Brugia malayi nuclear receptor NHR-67 0.0074 0.2685 0.3028
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.6328 0.7243
Brugia malayi nuclear receptor NHR-88 0.0074 0.2685 0.3028
Loa Loa (eye worm) hypothetical protein 0.0074 0.2685 0.3083
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0693 0.1175
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.4251 1
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.4251 0.6651
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0715 0.0803
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0693 0.3944
Brugia malayi ecdysteroid receptor 0.0157 0.6392 0.7317
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.4251 0.6651
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.4251 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0693 0.0484
Brugia malayi Nuclear hormone receptor E75 0.0074 0.2685 0.3028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0074 0.2685 0.2161
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0074 0.2685 0.4201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0157 0.6392 0.7317
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0669 0.0768
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.142 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.3082 0.3539
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0936 0.1464
Loa Loa (eye worm) hypothetical protein 0.0157 0.6392 0.7338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0074 0.2685 0.4201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0157 0.6392 0.7338
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0693 0.4153
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.4251 1
Brugia malayi 6-phosphofructokinase 0.0109 0.4251 0.484
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0157 0.6392 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0074 0.2685 0.3995
Echinococcus granulosus Nuclear hormone receptor HR96 0.0074 0.2685 0.4201
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.2542 0.3763
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0157 0.6392 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0074 0.2685 0.3028
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2211 0.494
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.2542 0.5761
Echinococcus granulosus lamin 0.0029 0.0669 0.1047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.2542 0.5761
Brugia malayi nuclear hormone receptor family member nhr-6 0.0074 0.2685 0.3028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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