Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0081 | 0.275 | 0.5294 |
Loa Loa (eye worm) | BEN-1 protein | 0.0081 | 0.274 | 0.2772 |
Entamoeba histolytica | tubulin family protein | 0.0081 | 0.274 | 0.5268 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0719 | 0.0346 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0115 | 0.4472 | 0.9555 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0081 | 0.274 | 0.5268 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0052 | 0.1273 | 0.1637 |
Loa Loa (eye worm) | beta-tubulin | 0.0081 | 0.274 | 0.2772 |
Brugia malayi | beta-tubulin, identical | 0.0081 | 0.274 | 0.5268 |
Loa Loa (eye worm) | tubulin beta chain | 0.0081 | 0.274 | 0.2772 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0081 | 0.274 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.004 | 0.0611 | 0.0426 |
Brugia malayi | Tubulin beta-1 chain | 0.0081 | 0.274 | 0.5268 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0118 | 0.4652 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0118 | 0.4652 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0198 | 0.876 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0081 | 0.274 | 0.0303 |
Entamoeba histolytica | tubulin family protein | 0.0081 | 0.274 | 0.5268 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4652 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0081 | 0.274 | 0.5268 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0057 | 0.151 | 0.5512 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0077 | 0.2513 | 0.4706 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0081 | 0.274 | 0.5268 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0118 | 0.4652 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0081 | 0.274 | 0.547 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0094 | 0.3412 | 0.6931 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0081 | 0.274 | 0.2772 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0081 | 0.274 | 0.5268 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Giardia lamblia | Beta tubulin | 0.0081 | 0.274 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Plasmodium vivax | tubulin beta chain, putative | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.3928 | 0.8209 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0081 | 0.274 | 0.2772 |
Echinococcus granulosus | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Echinococcus multilocularis | tubulin subunit beta | 0.0081 | 0.274 | 0.0303 |
Plasmodium falciparum | tubulin beta chain | 0.0081 | 0.274 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.3412 | 0.6931 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0081 | 0.274 | 0.0303 |
Loa Loa (eye worm) | BEN-1 protein | 0.0081 | 0.274 | 0.2772 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Echinococcus multilocularis | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Giardia lamblia | Beta tubulin | 0.0081 | 0.274 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0118 | 0.4652 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4652 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0081 | 0.275 | 0.5294 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | tubulin, putative | 0.0081 | 0.274 | 0.5268 |
Giardia lamblia | Beta tubulin | 0.0081 | 0.274 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0081 | 0.274 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0081 | 0.274 | 0.2772 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0081 | 0.274 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0081 | 0.274 | 0.5268 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0118 | 0.4652 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2513 | 0.2499 |
Echinococcus multilocularis | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.11 uM | Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hr | ChEMBL. | 24900252 |
EC50 (functional) | = 0.14 uM | Antiproliferative activity against human A2780 cells | ChEMBL. | 24900252 |
IC50 (binding) | = 0.007 uM | Inhibition of PI3Kalpha after 15 mins | ChEMBL. | 24900252 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24900252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.