TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.347 | Formula: C18H18N2O3
H donors: 1 H acceptors: 2 LogP: 2.32 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1O)C1CC(=NN1C(=O)C)c1ccccc1
InChi: 1S/C18H18N2O3/c1-12(21)20-16(14-8-9-17(22)18(10-14)23-2)11-15(19-20)13-6-4-3-5-7-13/h3-10,16,22H,11H2,1-2H3
InChiKey: LBHCBNVUCHSTNV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.1028	0.1028
Loa Loa (eye worm)	melatonin receptor type 1A	0.0027	0.052	0.0579
Schistosoma mansoni	amine GPCR	0.0027	0.052	0.052
Schistosoma mansoni	neuropeptide receptor	0.0027	0.052	0.052
Echinococcus granulosus	g protein coupled receptor	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	neuropeptide receptor A26	0.0027	0.052	0.0579
Schistosoma mansoni	neuropeptide receptor	0.0027	0.052	0.052
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0032	0.1028	0.1145
Brugia malayi	Serotonin receptor	0.0027	0.052	0.0579
Brugia malayi	putative neuropeptide receptor NPR1	0.0027	0.052	0.0579
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0027	0.052	0.0579
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.052	0.0579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.052	0.0579
Echinococcus granulosus	fmrfamide receptor	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.052	0.0579
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	AKH receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0111	0.8972	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.052	0.0579
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0027	0.052	0.0579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Brugia malayi	sulfakinin receptor protein	0.0027	0.052	0.0579
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0027	0.052	0.0579
Brugia malayi	Serotonin receptor	0.0027	0.052	0.0579
Echinococcus granulosus	7TM GPCR rhodopsin	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	larval opioid receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0032	0.1028	0.1145
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0027	0.052	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0027	0.052	0.0579
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0027	0.052	0.0579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Schistosoma mansoni	amine GPCR	0.0027	0.052	0.052
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0027	0.052	0.0579
Echinococcus multilocularis	serotonin receptor	0.0027	0.052	0.0579
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.052	0.052
Echinococcus granulosus	neuropeptide receptor	0.0027	0.052	0.0579
Schistosoma mansoni	opsin-like receptor	0.0027	0.052	0.052
Echinococcus granulosus	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	neuropeptide receptor	0.0027	0.052	0.052
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0027	0.052	0.0579
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.052	0.0579
Echinococcus multilocularis	g-protein coupled receptor	0.0027	0.052	0.0579
Schistosoma mansoni	amine GPCR	0.0027	0.052	0.052
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.052	0.0579
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0027	0.052	0.0579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0027	0.052	0.0579
Brugia malayi	G protein-coupled receptor	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	neuropeptide f receptor 76f	0.0027	0.052	0.052
Echinococcus granulosus	g-protein coupled receptor	0.0027	0.052	0.0579
Schistosoma mansoni	histamine h1 receptor	0.0027	0.052	0.052
Schistosoma mansoni	adenoreceptor	0.0027	0.052	0.052
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.052	0.052
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0027	0.052	0.0579
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.8236	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0027	0.052	0.052
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.1028	0.1028
Brugia malayi	Dopamine receptor protein 2	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0027	0.052	0.052
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0027	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	serotonin receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0111	0.8972	1
Echinococcus granulosus	somatostatin receptor	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	7tm_1 domain containing protein	0.0027	0.052	0.0579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Echinococcus granulosus	g protein coupled receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0027	0.052	0.0579
Echinococcus multilocularis	serotonin receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.052	0.052
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0027	0.052	0.052
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.052	0.052
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	neuropeptide F receptor	0.0027	0.052	0.0579
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.052	0.052
Schistosoma mansoni	amine GPCR	0.0027	0.052	0.052
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	allatostatin A receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	TYRA-2 protein	0.0027	0.052	0.0579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0027	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	opsin-like receptor	0.0027	0.052	0.052
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.052	0.052
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0096	0.7495	0.8354
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Schistosoma mansoni	myosin xvIII	0.0027	0.052	0.052
Echinococcus granulosus	orexin receptor type 2	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0027	0.052	0.0579
Echinococcus multilocularis	voltage gated potassium channel	0.0032	0.1028	0.1145
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0027	0.052	0.0579
Schistosoma mansoni	growth hormone secretagogue receptor	0.0027	0.052	0.052
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.052	0.052
Echinococcus granulosus	sex peptide receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus multilocularis	allatostatin A receptor	0.0027	0.052	0.0579
Echinococcus granulosus	dro:myosuppressin receptor	0.0027	0.052	0.0579
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1028	0.1145
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.052	0.0579
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.052	0.0579
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0027	0.052	0.052
Echinococcus multilocularis	sex peptide receptor	0.0027	0.052	0.0579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.052	0.0579
Brugia malayi	follicle stimulating hormone receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	G-protein coupled receptor	0.0027	0.052	0.0579
Echinococcus granulosus	neuropeptide s receptor	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Schistosoma mansoni	hypothetical protein	0.0027	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.052	0.0579
Schistosoma mansoni	amine GPCR	0.0027	0.052	0.052
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0027	0.052	0.0579
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0027	0.052	0.052
Echinococcus granulosus	neuropeptide receptor	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	GnHR receptor homolog	0.0027	0.052	0.0579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	opsin-like receptor	0.0027	0.052	0.052
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.052	0.052
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0027	0.052	0.0579
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0111	0.8972	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0027	0.052	0.052
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	G protein coupled receptor 139	0.0027	0.052	0.0579
Schistosoma mansoni	hypothetical protein	0.0027	0.052	0.052
Echinococcus multilocularis	dro:myosuppressin receptor	0.0027	0.052	0.0579
Brugia malayi	ORL1-like opioid receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	G protein coupled receptor 139	0.0027	0.052	0.0579
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0027	0.052	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0103	0.8236	1
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.052	0.0579
Schistosoma mansoni	neuropeptide receptor	0.0027	0.052	0.052
Brugia malayi	Dopamine receptor protein 1	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Brugia malayi	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	voltage gated potassium channel	0.0032	0.1028	0.1145
Brugia malayi	G protein-coupled receptor F59B2.13	0.0027	0.052	0.0579
Schistosoma mansoni	hypothetical protein	0.0027	0.052	0.052
Brugia malayi	Dopamine receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0027	0.052	0.0579
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0032	0.1028	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0027	0.052	0.0579
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0027	0.052	0.052
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.052	0.052
Schistosoma mansoni	biogenic amine receptor	0.0027	0.052	0.052
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.052	0.0579
Onchocerca volvulus		0.0027	0.052	0.5
Onchocerca volvulus		0.0027	0.052	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0027	0.052	0.0579
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	biogenic amine receptor	0.0027	0.052	0.052
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0027	0.052	0.0579
Echinococcus multilocularis	orexin receptor type 2	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.052	0.0579
Echinococcus granulosus	g protein coupled receptor	0.0027	0.052	0.0579
Echinococcus multilocularis	somatostatin receptor	0.0027	0.052	0.0579
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.052	0.0579
Brugia malayi	RE15519p	0.0027	0.052	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0027	0.052	0.0579
Schistosoma mansoni	hypothetical protein	0.0027	0.052	0.052
Echinococcus multilocularis	neuropeptide s receptor	0.0027	0.052	0.0579
Brugia malayi	Melatonin receptor type 1A	0.0027	0.052	0.0579
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0111	0.8972	1
Onchocerca volvulus		0.0027	0.052	0.5
Schistosoma mansoni	biogenic amine receptor	0.0027	0.052	0.052
Brugia malayi	neuropeptide F receptor	0.0027	0.052	0.0579
Brugia malayi	putative neuropeptide receptor	0.0027	0.052	0.0579
Brugia malayi	G-protein coupled receptor	0.0027	0.052	0.0579

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4.99 uM	Cytotoxicity against Homo sapiens (human) Hep2 cells after 48 hr by SRB assay	ChEMBL.	No reference
IC50 (binding)	= 81.2 uM	Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry	ChEMBL.	21353569

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1684637

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1504977