Detailed information for compound 1505446

Basic information

Technical information
  • TDR Targets ID: 1505446
  • Name: 4-[4-[[(3S)-1-butyl-3-[(R)-cyclohexyl-hydroxy methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec an-9-yl]methyl]phenoxy]benzoic acid hydrochlo ride
  • MW: 614.172 | Formula: C33H44ClN3O6
  • H donors: 3 H acceptors: 5 LogP: 3.92 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCN1C(=O)[C@@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O.Cl
  • InChi: 1S/C33H43N3O6.ClH/c1-2-3-19-36-30(38)28(29(37)24-7-5-4-6-8-24)34-32(41)33(36)17-20-35(21-18-33)22-23-9-13-26(14-10-23)42-27-15-11-25(12-16-27)31(39)40;/h9-16,24,28-29,37H,2-8,17-22H2,1H3,(H,34,41)(H,39,40);1H/t28-,29+;/m0./s1
  • InChiKey: QNNBMSGFNQRUEH-QBYKQQEBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[4-[[(3S)-1-butyl-3-[(R)-cyclohexyl-hydroxy-methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid hydrochloride
  • 4-[4-[[(3S)-1-butyl-3-[(R)-cyclohexyl-hydroxy-methyl]-2,5-diketo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0067 0.0342 0.0212
Giardia lamblia Pyruvate kinase 0.0037 0.0132 0.0443
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0278 0.1105
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0296 0.1238
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0024 0.0042 0.0088
Toxoplasma gondii ABC1 family protein 0.0225 0.1456 1
Mycobacterium tuberculosis Probable lipase LipD 0.0225 0.1456 0.1341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.009
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0352 0.0743
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0223 0.0524
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0132 0.0273
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0021 0.0039
Brugia malayi Cytochrome P450 family protein 0.0086 0.048 0.0693
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.003
Loa Loa (eye worm) beta-lactamase 0.0225 0.1456 0.2161
Echinococcus granulosus neuroglian 0.0024 0.0042 0.0088
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Echinococcus multilocularis SAM and MBT domain containing protein 0.0098 0.0561 0.1184
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1264 0.3018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0841 0.1778
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0304 0.0451
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0118
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0132 0.0254
Brugia malayi nuclear hormone receptor 0.0021 0.0021 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0419 0.0884
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0021 0.0045
Brugia malayi MAP kinase sur-1 0.0103 0.0598 0.0868
Loa Loa (eye worm) hypothetical protein 0.0273 0.1795 0.2666
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0067 0.0342 0.0996
Schistosoma mansoni lipoxygenase 0.0057 0.0273 0.0642
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0278 0.0587
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0079 0.0168
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0401 0.2702 0.5707
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.1264 0.1877
Loa Loa (eye worm) hypothetical protein 0.006 0.0296 0.0439
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0201 0.025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0278 0.1105
Brugia malayi cytochrome P450 0.0067 0.0342 0.0488
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0022
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0181 0.0382
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0067 0.0342 0.0996
Mycobacterium tuberculosis Probable esterase LipL 0.0225 0.1456 0.1341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0021 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.039 0.0825
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0304 0.0451
Schistosoma mansoni nephrin 0.0024 0.0042 0.0089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0276 0.039
Echinococcus multilocularis roundabout 2 0.0024 0.0042 0.0088
Echinococcus multilocularis 0.0067 0.0342 0.0722
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0067 0.0342 0.1587
Schistosoma mansoni septate junction protein 0.0024 0.0042 0.0089
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0148 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0021 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0841 0.1778
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.3355 0.7087
Brugia malayi Cytochrome P450 family protein 0.0086 0.048 0.0693
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0278 0.0587
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0149 0.0315
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0061 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0013
Echinococcus multilocularis dual specificity protein kinase clk2 0.0203 0.1305 0.2756
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0042 0.0165 0.0349
Onchocerca volvulus 0.0021 0.0021 0.0016
Echinococcus multilocularis histone acetyltransferase MYST2 0.0111 0.0656 0.1386
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0352 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0225 0.1456 0.2161
Schistosoma mansoni inositol monophosphatase 0.0044 0.0181 0.0422
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.1795 0.3793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0598 0.1262
Schistosoma mansoni hypothetical protein 0.0043 0.0177 0.0413
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0024 0.0042 0.0089
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.3355 0.7087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Mycobacterium leprae conserved hypothetical protein 0.0225 0.1456 1
Echinococcus granulosus twitchin 0.0056 0.0268 0.0565
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0201 0.1353
Echinococcus granulosus RUN 0.002 0.0014 0.003
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0142 0.0477
Brugia malayi Cytochrome P450 family protein 0.0067 0.0342 0.0488
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0561 0.1332
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0067 0.0342 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0021 0.0031
Loa Loa (eye worm) CYP4Cod1 0.0086 0.048 0.0713
Echinococcus granulosus single minded 2 0.0037 0.0132 0.0278
Echinococcus granulosus hypothetical protein 0.0199 0.1278 0.2699
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0042 0.0165 0.0384
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0067 0.0342 0.1587
Mycobacterium tuberculosis Probable lipase LipE 0.0225 0.1456 0.1341
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1264 0.3018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0021 0.001
Brugia malayi Bromodomain containing protein 0.0082 0.0449 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1305 0.3115
Echinococcus granulosus lachesin 0.0024 0.0042 0.0088
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0021 0.0039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0419 0.1292
Loa Loa (eye worm) doublecortin family protein 0.002 0.0014 0.0021
Trichomonas vaginalis esterase, putative 0.0225 0.1456 0.4813
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0598 0.1903
Brugia malayi TAR-binding protein 0.0197 0.1264 0.186
Echinococcus multilocularis roundabout 2 0.0024 0.0042 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0079
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0225 0.1456 0.1341
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0067 0.0342 0.0212
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0149 0.0315
Brugia malayi follicle stimulating hormone receptor 0.0972 0.6736 1
Schistosoma mansoni kinase 0.0218 0.1409 0.3366
Trypanosoma brucei cytochrome P450, putative 0.0086 0.048 0.1487
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0126 0.0267
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0263 0.037
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0132 0.0273
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0021 0.0045
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0181 0.0426
Schistosoma mansoni cell adhesion molecule 0.0024 0.0042 0.0089
Echinococcus multilocularis Immunoglobulin 0.0042 0.0165 0.0349
Schistosoma mansoni vesicular amine transporter 0.0042 0.0165 0.0384
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Schistosoma mansoni survival motor neuron protein 0.0056 0.0263 0.0619
Brugia malayi PHD-finger family protein 0.0058 0.0279 0.0395
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0022
Mycobacterium tuberculosis Conserved protein 0.0225 0.1456 0.1341
Mycobacterium ulcerans esterase/lipase LipP 0.0225 0.1456 1
Schistosoma mansoni single-minded 0.005 0.0223 0.0524
Brugia malayi beta-lactamase family protein 0.0225 0.1456 0.2145
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0021 0.0016
Schistosoma mansoni polycystin 1-related 0.002 0.0014 0.0022
Entamoeba histolytica hypothetical protein 0.0043 0.0177 0.0438
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0419 0.1041
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0181 0.1213
Echinococcus multilocularis pyruvate kinase 0.0019 0.0005 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0021 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0067 0.0342 0.0212
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0278 0.077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0181 0.0176
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0024 0.0042 0.0088
Loa Loa (eye worm) hypothetical protein 0.0225 0.1456 0.2161
Brugia malayi hypothetical protein 0.0043 0.0177 0.0243
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0067 0.0342 0.0996
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0426 0.2882 0.4279
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1264 0.3018
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0042 0.0088
Loa Loa (eye worm) hypothetical protein 0.0098 0.0561 0.0833
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.003
Schistosoma mansoni titin 0.0024 0.0042 0.0089
Echinococcus multilocularis 0.0199 0.1278 0.2699
Echinococcus granulosus dnaJ subfamily B 0.042 0.2839 0.5997
Chlamydia trachomatis pyruvate kinase 0.0037 0.0132 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0598 0.142
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0419 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0067 0.0342 0.0212
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0598 0.1262
Loa Loa (eye worm) hypothetical protein 0.0037 0.0132 0.0197
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0126 0.0267
Echinococcus granulosus zinc finger protein 0.0047 0.0202 0.0427
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0067 0.0342 0.1587
Schistosoma mansoni serine/threonine protein kinase 0.0426 0.2882 0.6894
Brugia malayi hypoxia-induced factor 1 0.0155 0.0963 0.1412
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0021
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0055 0.0261 0.0552
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0181 0.0176
Echinococcus granulosus beta LACTamase domain containing family member 0.0225 0.1456 0.3075
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0203 0.1305 0.4409
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0021 0.0045
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0142 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0021 0.0031
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0352 0.1031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0296 0.0165
Echinococcus multilocularis tar DNA binding protein 0.0197 0.1264 0.267
Leishmania major protein kinase, putative 0.0203 0.1305 0.4409
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0021 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0151 0.0224
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0132 0.0197
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0067 0.0342 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0352 0.0502
Schistosoma mansoni lamin 0.0061 0.0304 0.0716
Loa Loa (eye worm) hypothetical protein 0.0087 0.0485 0.072
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0972 0.6736 1
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1264 0.3018
Loa Loa (eye worm) inositol-1 0.0044 0.0181 0.0269
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0021 0.0016
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0352 0.0522
Echinococcus multilocularis lamin dm0 0.0061 0.0304 0.0641
Loa Loa (eye worm) hypothetical protein 0.0066 0.0337 0.05
Loa Loa (eye worm) hypothetical protein 0.0101 0.0582 0.0864
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0067 0.0342 0.0212
Loa Loa (eye worm) hypothetical protein 0.0145 0.0894 0.1327
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0067 0.0342 0.0212
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0352 0.1056
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Onchocerca volvulus 0.0098 0.0561 0.1261
Mycobacterium tuberculosis Conserved protein 0.0225 0.1456 0.1341
Brugia malayi Immunoglobulin I-set domain containing protein 0.0679 0.4663 0.6917
Echinococcus granulosus polycomb protein SCMH1 0.0098 0.0561 0.1184
Loa Loa (eye worm) hypothetical protein 0.0225 0.1456 0.2161
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0111 0.0656 0.1386
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0426 0.2882 0.6088
Schistosoma mansoni hypothetical protein 0.0031 0.0092 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0126 0.0291
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0111 0.0656 0.0955
Onchocerca volvulus 0.0225 0.1456 0.3327
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0132 0.0176
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.3355 0.7087
Loa Loa (eye worm) hypothetical protein 0.0111 0.0656 0.0974
Leishmania major pyruvate kinase 0.0037 0.0132 0.0254
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0021 0.0045
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0203 0.1305 0.4409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0021 0.0045
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0042 0.0165 0.0384
Loa Loa (eye worm) RNA binding protein 0.0197 0.1264 0.1877
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0225 0.1456 0.1341
Plasmodium vivax hypothetical protein, conserved 0.0225 0.1456 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0067 0.0342 0.1587
Mycobacterium tuberculosis Probable hydrolase 0.0225 0.1456 0.1341
Schistosoma mansoni cell adhesion molecule 0.0024 0.0042 0.0089
Schistosoma mansoni ap endonuclease 0.0078 0.0419 0.0991
Echinococcus multilocularis Immunoglobulin 0.0042 0.0165 0.0349
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0021 0.0045
Brugia malayi ecdysteroid receptor 0.0021 0.0021 0.001
Brugia malayi Inositol-1 0.0044 0.0181 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1305 0.3115
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0117 0.0247
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0598 0.0887
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0102 0.0152
Leishmania major hypothetical protein, conserved 0.0031 0.0092 0.011
Onchocerca volvulus 0.0061 0.0304 0.0668
Echinococcus granulosus tumor protein p63 0.0689 0.4734 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0598 0.1903
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0598 0.1903
Schistosoma mansoni hypothetical protein 0.0067 0.0342 0.0808
Echinococcus granulosus hemicentin 1 0.0024 0.0042 0.0088
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0181 0.0452
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0245
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0177 0.0374
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0419 0.1268
Toxoplasma gondii exonuclease III APE 0.0078 0.0419 0.2851
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0021 0.001
Mycobacterium leprae Conserved hypothetical protein 0.0067 0.0342 0.1583
Mycobacterium tuberculosis Conserved protein 0.0225 0.1456 0.1341
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0067 0.0342 0.1587
Trypanosoma brucei hypothetical protein, conserved 0.0225 0.1456 0.4945
Plasmodium vivax serine/threonine kinase-1, putative 0.0203 0.1305 0.8958
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0067 0.0342 0.0212
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0221 0.0517
Mycobacterium ulcerans hypothetical protein 0.0225 0.1456 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.1456 0.2161
Echinococcus multilocularis lachesin 0.0024 0.0042 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0148 0.0199
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0067 0.0342 0.1587
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0021 0.0039
Onchocerca volvulus 0.0056 0.0263 0.0574
Loa Loa (eye worm) hypothetical protein 0.0061 0.0304 0.0451
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0021 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0021 0.001
Echinococcus granulosus tar DNA binding protein 0.0197 0.1264 0.267
Schistosoma mansoni inositol monophosphatase 0.0044 0.0181 0.0422
Schistosoma mansoni lamin 0.0061 0.0304 0.0716
Loa Loa (eye worm) cytochrome P450 0.0067 0.0342 0.0508
Echinococcus granulosus lamin dm0 0.0061 0.0304 0.0641
Loa Loa (eye worm) hypothetical protein 0.0225 0.1456 0.2161
Schistosoma mansoni tyrosine kinase 0.0028 0.0069 0.0153
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0024 0.0042 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0201 0.025
Echinococcus granulosus pyruvate kinase 0.0019 0.0005 0.001
Leishmania major hypothetical protein, conserved 0.0225 0.1456 0.4945
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.0783 0.1654
Onchocerca volvulus 0.0225 0.1456 0.3327
Brugia malayi mbt repeat family protein 0.0098 0.0561 0.0813
Brugia malayi nuclear receptor NHR-88 0.0021 0.0021 0.001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0079 0.0168
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0067 0.0342 0.0212
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0203 0.1305 0.1937
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0061 0.0431
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0419 0.0602
Entamoeba histolytica hypothetical protein 0.0043 0.0177 0.0438
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0086 0.048 0.2633
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Brugia malayi beta-lactamase family protein 0.0225 0.1456 0.2145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0841 0.1778
Echinococcus granulosus histone acetyltransferase MYST2 0.0111 0.0656 0.1386
Mycobacterium leprae putative cytochrome p450 0.0067 0.0342 0.1583
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0067 0.0342 0.1587
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Onchocerca volvulus Tyrosine kinase homolog 0.0634 0.4348 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0245
Loa Loa (eye worm) cytochrome P450 family protein 0.0086 0.048 0.0713
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0177 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.137 0.4501
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0148 0.0121
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0067 0.0342 0.1587
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0117 0.0269
Echinococcus granulosus neuroglian 0.0052 0.0241 0.0508
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0132 0.028
Leishmania major protein kinase, putative 0.0203 0.1305 0.4409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0913 0.1929
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0021 0.0016
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0419 0.3183
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0067 0.0342 0.1587
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.1264 0.186
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0225 0.1456 0.2161
Trypanosoma cruzi cytochrome P450, putative 0.0086 0.048 0.1487
Echinococcus granulosus pyruvate kinase 0.0037 0.0132 0.028
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0296 0.1238
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0426 0.2882 0.6088
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0014 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0021 0.0045
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0201 0.1353
Loa Loa (eye worm) cytochrome P450 family protein 0.0086 0.048 0.0713
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0598 0.1903
Schistosoma mansoni cell adhesion molecule 0.0024 0.0042 0.0089
Echinococcus granulosus roundabout 2 0.0024 0.0042 0.0088
Onchocerca volvulus 0.0225 0.1456 0.3327
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0021 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0225 0.1456 0.1341
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0296 0.0624
Schistosoma mansoni neuroglian 0.0024 0.0042 0.0089
Schistosoma mansoni myelin transcription factor 1 myt1 0.0111 0.0656 0.1561
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0296 0.2003
Echinococcus granulosus roundabout 2 0.0066 0.0337 0.0711
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0203 0.1305 0.4409
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0419 0.1268
Schistosoma mansoni cpg binding protein 0.0067 0.0341 0.0805
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0021 0.0045
Loa Loa (eye worm) acetyltransferase 0.0148 0.0913 0.1356
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0963 0.143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0021 0.001
Echinococcus granulosus lamin 0.0061 0.0304 0.0641
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0021 0.0039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0276 0.041
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0419 0.1041
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0221 0.0466
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0021
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0067 0.0342 0.1587
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0024 0.0042 0.0088
Echinococcus multilocularis musashi 0.0061 0.0304 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0021 0.001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0111 0.0656 0.1386
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0021 0.0039
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0021 0.0039
Loa Loa (eye worm) TAR-binding protein 0.0197 0.1264 0.1877
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0419 0.0621
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0225 0.1456 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0419 0.1268
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0021 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0177 0.0374
Loa Loa (eye worm) hypothetical protein 0.0199 0.1278 0.1897
Schistosoma mansoni bromodomain containing protein 0.0137 0.0835 0.1989
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0014 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0276 0.039
Echinococcus multilocularis peroxidasin 0.0024 0.0042 0.0088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0419 0.2166
Brugia malayi Peroxidasin 0.0024 0.0042 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.1456 0.4813
Echinococcus multilocularis polycomb protein SCMH1 0.0098 0.0561 0.1184
Entamoeba histolytica serine/threonine protein kinase, putative 0.0426 0.2882 1
Echinococcus granulosus defective proboscis extension response 0.0042 0.0165 0.0349
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0203 0.1305 0.4409
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0278 0.0655
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0024 0.0042 0.0062
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0098 0.0561 0.1332
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Echinococcus granulosus SAM and MBT domain containing protein 0.0098 0.0561 0.1184
Brugia malayi steroid hormone receptor 0.0021 0.0021 0.001
Trypanosoma cruzi polo-like protein kinase, putative 0.0426 0.2882 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0289 0.043
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0132 0.0176
Trypanosoma brucei protein kinase, putative 0.0103 0.0598 0.1903
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0067 0.0342 0.0212
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0067 0.0342 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0225 0.1456 0.3477
Schistosoma mansoni zinc finger protein 0.0031 0.0092 0.0208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0021 0.0045
Loa Loa (eye worm) cytochrome P450 family protein 0.0186 0.1184 0.1758
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0679 0.4663 0.6924
Brugia malayi mbt repeat family protein 0.0098 0.0561 0.0813
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.1456 0.4945
Loa Loa (eye worm) MBCTL1 0.0111 0.0656 0.0974
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0021 0.001
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0061 0.0386
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0067 0.0342 0.0212
Echinococcus granulosus peroxidasin 0.0024 0.0042 0.0088
Schistosoma mansoni zinc finger protein 0.0047 0.0202 0.0473
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0419 0.1438
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.1456 0.4813
Loa Loa (eye worm) hypothetical protein 0.0057 0.0276 0.041
Schistosoma mansoni cpg binding protein 0.0067 0.0341 0.0805
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0021 0.001
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0026 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0021 0.0045
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0067 0.0342 0.1587
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0067 0.0342 0.0212
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0021 0.0045
Echinococcus multilocularis cpg binding protein 0.0067 0.0341 0.072
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0067 0.0342 0.1587
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.003
Mycobacterium ulcerans beta-lactamase 0.0225 0.1456 1
Giardia lamblia Kinase, CMGC CLK 0.0203 0.1305 0.4518
Echinococcus multilocularis beta LACTamase domain containing family member 0.0225 0.1456 0.3075
Mycobacterium ulcerans lipase LipD 0.0225 0.1456 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0419 0.1268
Schistosoma mansoni hypothetical protein 0.0056 0.0263 0.0619
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0352 0.1031
Schistosoma mansoni ap endonuclease 0.0078 0.0419 0.0991
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0598 0.1903
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0067 0.0342 0.0212
Brugia malayi Fibronectin type III domain containing protein 0.0042 0.0165 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0841 0.2005
Schistosoma mansoni loxhd1 0.002 0.0014 0.0022
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0203 0.1305 0.8958
Onchocerca volvulus 0.062 0.4246 0.9764
Brugia malayi CXXC zinc finger family protein 0.0059 0.0289 0.041
Echinococcus granulosus contactin 0.0024 0.0042 0.0088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.0783 0.1654
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0723 0.4952
Onchocerca volvulus 0.0061 0.0304 0.0668
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0042 0.0088
Echinococcus granulosus intermediate filament protein 0.0061 0.0304 0.0641
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0132 0.0254
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0067 0.0342 0.1587
Schistosoma mansoni hypothetical protein 0.0042 0.0169 0.0393
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0021 0.0045
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0273 0.0577
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0221 0.0466
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0021 0.0031
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0913 0.1338
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0304 0.0431
Echinococcus granulosus dual specificity protein kinase clk2 0.0203 0.1305 0.2756
Schistosoma mansoni roundabout 0.0024 0.0042 0.0089
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0132 0.0879
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0024 0.0042 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.1456 0.4813
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0245
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0245
Trichomonas vaginalis penicillin-binding protein, putative 0.0225 0.1456 0.4813
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0419 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0021 0.0039
Echinococcus multilocularis pyruvate kinase 0.0037 0.0132 0.028
Schistosoma mansoni cell adhesion molecule 0.0055 0.0261 0.0615
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0352 0.1031
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0067 0.0342 0.0212
Entamoeba histolytica hypothetical protein 0.0043 0.0177 0.0438
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0024 0.0042 0.0062
Onchocerca volvulus 0.0101 0.0582 0.1311
Trypanosoma brucei ISWI complex protein 0.0031 0.0092 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0086 0.048 0.1487
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0841 0.1249
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0759 0.1808
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0067 0.0342 0.1587
Echinococcus granulosus cytochrome P450 2K1 0.0067 0.0342 0.0722
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0296 0.0832
Leishmania major cytochrome p450-like protein 0.0086 0.048 0.1487
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0296 0.1238
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0201 0.0425
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0419 0.029
Trypanosoma cruzi polo-like protein kinase, putative 0.0426 0.2882 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0077 0.0163
Schistosoma mansoni pyruvate kinase 0.0037 0.0132 0.0306
Brugia malayi hypothetical protein 0.0273 0.1795 0.265
Echinococcus multilocularis RUN 0.002 0.0014 0.003
Brugia malayi intermediate filament protein 0.0061 0.0304 0.0431
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0021 0.0045
Leishmania major cytochrome p450-like protein 0.0067 0.0342 0.0996
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0188
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0132 0.0278
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0067 0.0342 0.0996
Brugia malayi Prion-like- 0.0024 0.0042 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0021 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0203 0.1305 0.4263
Echinococcus granulosus neuropeptide s receptor 0.0493 0.3355 0.7087
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0913 0.2177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0165 0.0225
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0014 0.0064
Echinococcus multilocularis roundabout 2 0.0066 0.0337 0.0711
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0106
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0132 0.0254
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0582 0.1384
Brugia malayi hypothetical protein 0.0027 0.0061 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0067 0.0342 0.0212
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0225 0.1456 0.2145
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0142 0.1057
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0067 0.0342 0.1587
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0132 0.0254
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0598 0.1903
Echinococcus multilocularis hemicentin 1 0.0024 0.0042 0.0088
Toxoplasma gondii cytochrome p450 superfamily protein 0.0067 0.0342 0.2323
Loa Loa (eye worm) hypothetical protein 0.0079 0.0426 0.0632
Leishmania major cytochrome p450-like protein 0.0067 0.0342 0.0996
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Trypanosoma cruzi ISWI complex protein 0.0031 0.0092 0.011
Loa Loa (eye worm) hypothetical protein 0.0168 0.1055 0.1566
Echinococcus granulosus tyrosine protein kinase otk 0.0024 0.0042 0.0088
Entamoeba histolytica hypothetical protein 0.0043 0.0177 0.0438
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0181 0.0382
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0021 0.0045
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0132 0.0197
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0132 0.0879
Echinococcus granulosus pyruvate kinase 0.0019 0.0005 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0021 0.001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0426 0.2882 1
Loa Loa (eye worm) mbt repeat family protein 0.0098 0.0561 0.0833
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0067 0.0342 0.1587
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0062
Schistosoma mansoni nephrin 0.0052 0.0241 0.0565
Trichomonas vaginalis CAMK family protein kinase 0.0426 0.2882 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0021 0.001
Plasmodium falciparum protein serine/threonine kinase-1 0.0203 0.1305 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0132 0.0197
Brugia malayi Bromodomain containing protein 0.0161 0.1004 0.1473
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0102 0.0131
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0132 0.0273
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0021 0.0039
Schistosoma mansoni intermediate filament proteins 0.0061 0.0304 0.0716
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0181 0.0176
Loa Loa (eye worm) hypothetical protein 0.0066 0.0337 0.05
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0419 0.2851
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0851 0.1797
Loa Loa (eye worm) hypothetical protein 0.0094 0.0536 0.0796
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0419 0.0884
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0169 0.0251
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0181 0.0426
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0098 0.0561 0.1261
Giardia lamblia Kinase, PLK 0.0426 0.2882 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0021 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0021 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0841 0.2005
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0067 0.0342 0.1587
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0203 0.1305 0.4409
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.137 0.4501
Echinococcus multilocularis lamin 0.0061 0.0304 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0021 0.001
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0132 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0067 0.0342 0.0212
Echinococcus granulosus Immunoglobulin 0.0042 0.0165 0.0349
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0067 0.0342 0.1587
Schistosoma mansoni cpg binding protein 0.0059 0.0289 0.0682
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0067 0.0342 0.0996
Brugia malayi serine/threonine-protein kinase plk-2 0.0426 0.2882 0.4267
Brugia malayi Cytochrome P450 family protein 0.0186 0.1184 0.1741
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1264 0.3018
Schistosoma mansoni coup transcription factor 0.0021 0.0021 0.0039
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0014 0.0071
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0401 0.2702 0.5707
Brugia malayi RNA binding protein 0.0197 0.1264 0.186
Schistosoma mansoni hypothetical protein 0.042 0.2839 0.6791
Brugia malayi Protein kinase domain containing protein 0.0203 0.1305 0.192
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.039 0.0825
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.1456 0.4945
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0296 0.0697
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0067 0.0342 0.1587
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0278 0.0393
Onchocerca volvulus 0.0037 0.0132 0.0271
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0342
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0598 0.1692
Mycobacterium leprae Probable lipase LipE 0.0225 0.1456 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0388
Brugia malayi hypothetical protein 0.0168 0.1055 0.1548
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0561 0.1332
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0598 0.4085
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0598 0.1262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0021 0.001
Echinococcus multilocularis tumor protein p63 0.0689 0.4734 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0024 0.0042 0.0089
Brugia malayi PAS domain containing protein 0.005 0.0223 0.0311
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0053 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0021 0.0039
Echinococcus multilocularis pyruvate kinase 0.0019 0.0005 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0021 0.001
Echinococcus multilocularis tyrosine protein kinase otk 0.0024 0.0042 0.0088
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0181 0.0372
Onchocerca volvulus Serine\/threonine kinase homolog 0.0426 0.2882 0.6618
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0067 0.0342 0.0212
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0132 0.0175
Brugia malayi beta-lactamase 0.0225 0.1456 0.2145
Schistosoma mansoni pyruvate kinase 0.0037 0.0132 0.0306
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.003
Echinococcus granulosus pyruvate kinase 0.0019 0.0005 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0598 0.1692
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0201 0.1353
Echinococcus granulosus cpg binding protein 0.0067 0.0341 0.072
Plasmodium falciparum pyruvate kinase 0.0037 0.0132 0.0981
Leishmania major pyruvate kinase 0.0037 0.0132 0.0254
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0598 0.1692
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0598 0.1692
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0841 0.1778
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0106
Schistosoma mansoni lipoxygenase 0.002 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0245
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0296 0.0697
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0203 0.1305 0.4409
Echinococcus multilocularis pyruvate kinase 0.0019 0.0005 0.001
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0028 0.0069 0.0102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0245
Schistosoma mansoni cytochrome P450 0.0067 0.0342 0.0808
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0117 0.0247
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0841 0.1231
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.1795 0.3793
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0067 0.0342 0.1587
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0251 0.0372
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2839 0.5997
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0296 0.0624
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0117 0.0269
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0042 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0225 0.1456 0.4813
Echinococcus multilocularis pyruvate kinase 0.0037 0.0132 0.028
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0061 0.0431
Trypanosoma brucei polo-like protein kinase 0.0426 0.2882 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0126 0.0291
Echinococcus multilocularis zinc finger protein 0.0047 0.0202 0.0427
Echinococcus granulosus roundabout 2 0.0024 0.0042 0.0088
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0021 0.0039
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0181 0.0426
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0598 0.1903
Schistosoma mansoni septate junction protein 0.0024 0.0042 0.0089
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0024 0.0042 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0841 0.2005
Echinococcus multilocularis neuroglian 0.0052 0.0241 0.0508
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0352 0.0743
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0598 0.206
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0225 0.1456 0.2161
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0021 0.0045
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0273 0.0577
Onchocerca volvulus 0.0059 0.0289 0.0635
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0021 0.0039
Echinococcus multilocularis neuroglian 0.0024 0.0042 0.0088
Echinococcus multilocularis hemicentin 1 0.0024 0.0042 0.0088
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0598 0.1262
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0067 0.0342 0.0212
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0278 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0225 0.1456 0.3477
Brugia malayi hypothetical protein 0.0042 0.0165 0.0225
Schistosoma mansoni hypothetical protein 0.061 0.4178 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0352 0.0831
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0181 0.0426
Trypanosoma cruzi ISWI complex protein 0.0031 0.0092 0.011

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.42 Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay ChEMBL. 21256008
IC50 (functional) = 470 nM Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay ChEMBL. 21256008
IC50 (ADMET) > 30 uM Inhibition of CYP2C9 ChEMBL. 21256008
IC50 (ADMET) > 30 uM Inhibition of CYP2D6 ChEMBL. 21256008
IC50 (ADMET) > 30 uM Inhibition of CYP3A4 ChEMBL. 21256008
IC50 (functional) = 380 uM Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay ChEMBL. 21658961
IC50 (functional) = 470 uM Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization ChEMBL. 21658961
permeability (ADMET) = 1.6 10'-6 cm/s Permeability across human Caco2 cell membrane ChEMBL. 21256008

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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