Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0105 | 0.0429 | 0.1286 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0072 | 0.0096 | 0.0096 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0072 | 0.0096 | 0.0096 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0338 | 0.2763 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0105 | 0.0429 | 0.1428 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0395 | 0.3334 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0105 | 0.0429 | 0.0429 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0072 | 0.0096 | 0.0288 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0362 | 0.3001 | 0.3001 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0429 | 0.1428 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0362 | 0.3001 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0072 | 0.0096 | 0.0096 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0072 | 0.0096 | 0.0288 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0105 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0072 | 0.0096 | 0.032 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0072 | 0.0096 | 0.0288 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0338 | 0.2763 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0072 | 0.0096 | 0.0096 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0395 | 0.3334 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0072 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.2523 | 0.8406 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0362 | 0.3001 | 0.3001 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0072 | 0.0096 | 0.0288 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0072 | 0.0096 | 0.0096 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0072 | 0.0096 | 0.0096 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0105 | 0.0429 | 0.1286 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0072 | 0.0096 | 0.0288 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0105 | 0.0429 | 0.0429 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0072 | 0.0096 | 0.0096 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0072 | 0.0096 | 0.0096 |
Echinococcus granulosus | voltage gated potassium channel | 0.0105 | 0.0429 | 0.0429 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0072 | 0.0096 | 0.0096 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0072 | 0.0096 | 0.0096 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0072 | 0.0096 | 0.0288 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0362 | 0.3001 | 1 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0072 | 0.0096 | 0.032 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0072 | 0.0096 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0096 | 0.032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 230 nM | BindingDB_Patents: Functional Assay. Functional assay using 5-HT6 receptors. | ChEMBL. | No reference |
IC50 (binding) | = 230 nM | BindingDB_Patents: Functional Assay. Functional assay using 5-HT6 receptors. | ChEMBL. | No reference |
Ki (functional) | = 8.5 | Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after 2 hrs | ChEMBL. | 21277782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.