TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 510.511 | Formula: C26H25F3N6O2
H donors: 0 H acceptors: 4 LogP: 4.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1nc(cc2c1ncn2C)c1ccc(c(c1)C(F)(F)F)OCCC1CCN(CC1)Cc1ncco1
InChi: 1S/C26H25F3N6O2/c1-34-16-32-25-21(14-30)33-20(13-22(25)34)18-2-3-23(19(12-18)26(27,28)29)36-10-6-17-4-8-35(9-5-17)15-24-31-7-11-37-24/h2-3,7,11-13,16-17H,4-6,8-10,15H2,1H3
InChiKey: IKBUAFVMVGRIRN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin V	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Mus musculus	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	341 aa	375 aa	29.9 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cysteine protease	0.014	0.6687	0.6687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Schistosoma mansoni	voltage-gated potassium channel	0.0166	0.8378	0.8378
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.008	0.2773	0.2773
Brugia malayi	Cathepsin L-like precursor	0.0095	0.3788	0.3788
Brugia malayi	Cathepsin L-like precursor	0.0095	0.3788	0.3788
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0074	0.2435	0.2042
Plasmodium vivax	vivapain-3	0.0074	0.2435	0.3135
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.008	0.2773	0.0769
Onchocerca volvulus		0.0095	0.3788	0.5665
Echinococcus multilocularis	cathepsin L cysteine protease	0.014	0.6687	0.6687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Echinococcus multilocularis	voltage gated potassium channel	0.0044	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Echinococcus granulosus	cathepsin L	0.0074	0.2435	0.2435
Echinococcus multilocularis	cathepsin L cysteine protease	0.014	0.6687	0.6687
Giardia lamblia	Cathepsin B precursor	0.008	0.2773	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3788	0.3788
Loa Loa (eye worm)	hypothetical protein	0.014	0.6687	0.6687
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Trypanosoma cruzi	cysteine peptidase, putative	0.014	0.6687	0.6515
Echinococcus multilocularis	cathepsin L	0.0074	0.2435	0.2435
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.2435	0.2435
Plasmodium vivax	vivapain-1	0.0074	0.2435	0.3135
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0095	0.3788	0.3788
Brugia malayi	cathepsin F-like cysteine proteinase	0.0045	0.0493	0.0493
Schistosoma mansoni	cathepsin F (C01 family)	0.0095	0.3788	0.3788
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Echinococcus granulosus	cathepsin l1	0.0095	0.3788	0.3788
Entamoeba histolytica	cysteine proteinase, putative	0.014	0.6687	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Echinococcus granulosus	cysteine protease	0.0074	0.2435	0.2435
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0152	0.7471	0.7471
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0044	0.0456	0.0456
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0095	0.3788	0.3465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Onchocerca volvulus		0.014	0.6687	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0074	0.2435	0.2435
Loa Loa (eye worm)	cathepsin B	0.008	0.2773	0.2773
Plasmodium vivax	unspecified product	0.0074	0.2435	0.3135
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Entamoeba histolytica	cysteine proteinase, putative	0.014	0.6687	1
Loa Loa (eye worm)	fibroinase	0.014	0.6687	0.6687
Trypanosoma cruzi	cysteine peptidase, putative	0.014	0.6687	0.6515
Brugia malayi	Cathepsin L-like precursor	0.014	0.6687	0.6687
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0074	0.2435	0.2435
Loa Loa (eye worm)	cysteine protease	0.014	0.6687	0.6687
Trypanosoma cruzi	cruzipain precursor, putative	0.014	0.6687	0.6515
Brugia malayi	cathepsin L-like precursor	0.0095	0.3788	0.3788
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0152	0.7471	0.7471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Echinococcus multilocularis	cysteine protease	0.014	0.6687	0.6687
Onchocerca volvulus		0.014	0.6687	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0074	0.2435	0.2435
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0493	0.0493
Plasmodium vivax	vivapain-2	0.014	0.6687	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.014	0.6687	1
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.3788	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0152	0.7471	0.7471
Brugia malayi	Cathepsin L-like precursor	0.014	0.6687	0.6687
Trypanosoma cruzi	cysteine proteinase, putative	0.0074	0.2435	0.2042
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0044	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Entamoeba histolytica	cysteine protease, putative	0.014	0.6687	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3788	0.3788
Trypanosoma cruzi	cysteine peptidase, putative	0.014	0.6687	0.6515
Echinococcus granulosus	cathepsin l cysteine peptidase	0.014	0.6687	0.6687
Echinococcus granulosus	cathepsin l1	0.014	0.6687	0.6687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.6167	0.6167
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0456	0.0456
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.014	0.6687	0.6687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Brugia malayi	Cathepsin L-like precursor	0.014	0.6687	0.6687
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0074	0.2435	0.2435
Onchocerca volvulus		0.014	0.6687	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0074	0.2435	0.2042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Onchocerca volvulus	Cathepsin F homolog	0.014	0.6687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.3788	0.3084
Brugia malayi	Cathepsin L-like precursor	0.014	0.6687	0.6687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.2435	0.2042
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0045	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.3788	0.3084
Giardia lamblia	Cathepsin B precursor	0.008	0.2773	0.5
Schistosoma mansoni	cathepsin s	0.0045	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.014	0.6687	0.9693
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.008	0.2773	0.2397
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0456	0.0456
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Plasmodium vivax	vivapain-2	0.014	0.6687	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0142	0.6821	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0152	0.7471	0.7471
Onchocerca volvulus		0.014	0.6687	1
Onchocerca volvulus		0.014	0.6687	1
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Leishmania major	cysteine peptidase A (CPA)	0.014	0.6687	1
Onchocerca volvulus	Cathepsin L homolog	0.014	0.6687	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.014	0.6687	1
Toxoplasma gondii	cathepsin CPL	0.014	0.6687	1
Brugia malayi	Cathepsin L-like precursor	0.014	0.6687	0.6687
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Brugia malayi	Cathepsin L-like precursor	0.014	0.6687	0.6687
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.014	0.6687	0.6687
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.014	0.6687	0.6687
Echinococcus granulosus	voltage gated potassium channel	0.0044	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.2435	0.2435
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3788	0.3788
Schistosoma mansoni	cathepsin F (C01 family)	0.014	0.6687	0.6687
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Giardia lamblia	Cathepsin B precursor	0.008	0.2773	0.5
Onchocerca volvulus	Cathepsin L homolog	0.014	0.6687	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.008	0.2773	0.0794
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0044	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.014	0.6687	0.9693
Onchocerca volvulus		0.014	0.6687	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.014	0.6687	0.6687
Trypanosoma cruzi	cysteine peptidase, putative	0.014	0.6687	0.6515
Plasmodium falciparum	cysteine proteinase falcipain 3	0.014	0.6687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.014	0.6687	0.9693
Trypanosoma cruzi	cysteine protease, putative	0.0074	0.2435	0.2042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693
Brugia malayi	Papain family cysteine protease containing protein	0.014	0.6687	0.6687
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Onchocerca volvulus		0.014	0.6687	1
Leishmania major	cathepsin L-like protease	0.014	0.6687	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0045	0.0493	0.0493
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.014	0.6687	1
Loa Loa (eye worm)	ctsf protein	0.014	0.6687	0.6687
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0493	0.0493
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.014	0.6687	0.6687
Schistosoma mansoni	voltage-gated potassium channel	0.0166	0.8378	0.8378
Schistosoma mansoni	cathepsin F (C01 family)	0.014	0.6687	0.6687
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0142	0.6821	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.014	0.6687	0.9693

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)	= 13.9 ml/min.kg	Clearance in C57 mouse at 2 mg/kg, iv or 10 mg/kg, po	ChEMBL.	21227690
Cmax (ADMET)	= 3160 ng/ml	Cmax in C57 mouse at 2 mg/kg, iv or 10 mg/kg, po	ChEMBL.	21227690
Cp (ADMET)	= 6610 nM	Drug level in C57BI/6 mouse plasma at 30 mg/kg, po	ChEMBL.	21227690
Drug uptake (ADMET)	= 12502 nM	Drug level in C57BI/6 mouse spleen at 30 mg/kg, po	ChEMBL.	21227690
F (ADMET)	= 112 %	Oral bioavailability in C57 mouse at 2 mg/kg, iv or 10 mg/kg, po	ChEMBL.	21227690
IC50 (binding)	= 1.6 nM	Inhibition of mouse cathepsin S	ChEMBL.	21227690
IC50 (binding)	= 7.9 nM	Inhibition of human cathepsin S	ChEMBL.	21227690
IC50 (binding)	= 39 nM	Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysis	ChEMBL.	21227690
IC50 (binding)	= 708 nM	Inhibition of human cathepsin K	ChEMBL.	21227690
IC50 (binding)	> 10 uM	Inhibition of human cathepsin B	ChEMBL.	21227690
IC50 (binding)	> 10 uM	Inhibition of human cathepsin V	ChEMBL.	21227690
IC50 (binding)	> 10 uM	Inhibition of human cathepsin L	ChEMBL.	21227690
Vdss (ADMET)	= 1.48 L/Kg	Volume of distribution at steady state in C57 mouse at 2 mg/kg, iv or 10 mg/kg, po	ChEMBL.	21227690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1669278

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1505560