Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0095 | 0.7583 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0095 | 0.7583 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0866 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.7583 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0866 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0095 | 0.7583 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0095 | 0.7583 | 0.7353 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0095 | 0.7583 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0866 | 0.0866 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2858 | 0.2858 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0095 | 0.7583 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0095 | 0.7583 | 1 |
Schistosoma mansoni | kinase | 0.0048 | 0.3078 | 0.0465 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0866 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0095 | 0.7583 | 0.7583 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0095 | 0.7583 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0095 | 0.7583 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.7583 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2858 | 0.218 |
Giardia lamblia | Kinase, PLK | 0.0095 | 0.7583 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0866 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 32 nM | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay | ChEMBL. | 20547797 |
IC50 (functional) | = 94 nM | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum TM90C2B by SYBR Green 1-based fluorescence assay | ChEMBL. | 20547797 |
IC50 (functional) | = 130 nM | Antiplasmodial activity against Plasmodium falciparum 3D7 by SYBR Green 1-based fluorescence assay | ChEMBL. | 20547797 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20547797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.