Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin L cysteine protease | 0.032 | 0.0928 | 0.0893 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0596 | 0.2876 | 0.2848 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1548 | 0.1548 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0194 | 0.0038 | 0.0068 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.032 | 0.0928 | 0.1649 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Loa Loa (eye worm) | amidase | 0.0194 | 0.0038 | 0.0038 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.032 | 0.0928 | 0.0928 |
Trypanosoma brucei | lipase domain protein, putative | 0.0283 | 0.067 | 0.2227 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0407 | 0.1548 | 0.1548 |
Trypanosoma brucei | lipase domain protein, putative | 0.0283 | 0.067 | 0.2227 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0395 | 0.1463 | 0.5021 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0194 | 0.0038 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0283 | 0.067 | 0.067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.032 | 0.0928 | 0.1649 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1548 | 0.1548 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0985 | 0.5624 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0395 | 0.1463 | 0.2601 |
Onchocerca volvulus | Cathepsin F homolog | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.032 | 0.0928 | 0.3135 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.032 | 0.0928 | 0.1649 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0194 | 0.0038 | 0.0038 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0407 | 0.1548 | 0.3978 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0596 | 0.2876 | 0.2876 |
Plasmodium vivax | vivapain-1 | 0.032 | 0.0928 | 0.3226 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0194 | 0.0038 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.032 | 0.0928 | 0.3135 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0283 | 0.067 | 0.0634 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Brugia malayi | Lipase family protein | 0.0283 | 0.067 | 0.067 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Plasmodium vivax | unspecified product | 0.032 | 0.0928 | 0.3226 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0283 | 0.067 | 0.1192 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Plasmodium vivax | vivapain-3 | 0.032 | 0.0928 | 0.3226 |
Echinococcus granulosus | cathepsin l1 | 0.0407 | 0.1548 | 0.1515 |
Toxoplasma gondii | cathepsin CPL | 0.0596 | 0.2876 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0596 | 0.2876 | 0.2876 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0407 | 0.1548 | 0.1548 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0596 | 0.2876 | 0.2848 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0441 | 0.1781 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0596 | 0.2876 | 0.5113 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0985 | 0.5624 | 0.5624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0283 | 0.067 | 0.1192 |
Giardia lamblia | Cathepsin B precursor | 0.0395 | 0.1463 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0407 | 0.1548 | 0.1548 |
Brugia malayi | Cathepsin L-like precursor | 0.0407 | 0.1548 | 0.1548 |
Echinococcus granulosus | cysteine protease | 0.032 | 0.0928 | 0.0893 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Brugia malayi | putative amidase | 0.0194 | 0.0038 | 0.0038 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0395 | 0.1463 | 0.3594 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0194 | 0.0038 | 0.0068 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0596 | 0.2876 | 0.2848 |
Onchocerca volvulus | Cathepsin L homolog | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0283 | 0.067 | 0.0634 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0407 | 0.1548 | 0.3978 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0395 | 0.1463 | 0.5021 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.032 | 0.0928 | 0.1168 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0407 | 0.1548 | 0.1548 |
Echinococcus granulosus | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Brugia malayi | Amidase family protein | 0.0194 | 0.0038 | 0.0038 |
Giardia lamblia | Cathepsin B precursor | 0.0395 | 0.1463 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.032 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.032 | 0.0928 | 0.1649 |
Onchocerca volvulus | 0.0407 | 0.1548 | 0.3978 | |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0194 | 0.0038 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.032 | 0.0928 | 0.3135 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0441 | 0.1781 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0194 | 0.0038 | 0.0133 |
Brugia malayi | Amidase family protein | 0.0194 | 0.0038 | 0.0038 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.032 | 0.0928 | 0.1168 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Echinococcus multilocularis | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.032 | 0.0928 | 0.0928 |
Plasmodium vivax | vivapain-2 | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | amidase | 0.0194 | 0.0038 | 0.0038 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Echinococcus granulosus | cathepsin l1 | 0.0596 | 0.2876 | 0.2848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0395 | 0.1463 | 0.1463 |
Echinococcus granulosus | cathepsin L | 0.032 | 0.0928 | 0.0893 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.032 | 0.0928 | 0.0928 |
Trypanosoma cruzi | cysteine protease, putative | 0.032 | 0.0928 | 0.1649 |
Brugia malayi | Papain family cysteine protease containing protein | 0.032 | 0.0928 | 0.0928 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Onchocerca volvulus | Cathepsin L homolog | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0194 | 0.0038 | 0.0038 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0395 | 0.1463 | 0.1463 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0283 | 0.067 | 0.2227 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0596 | 0.2876 | 0.2848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0407 | 0.1548 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Loa Loa (eye worm) | hypothetical protein | 0.0985 | 0.5624 | 0.5624 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0407 | 0.1548 | 0.2751 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0194 | 0.0038 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Echinococcus multilocularis | cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1548 | 0.1548 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Echinococcus multilocularis | cathepsin L | 0.032 | 0.0928 | 0.0893 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0194 | 0.0038 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0395 | 0.1463 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0596 | 0.2876 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.032 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs micro dilution assay | ChEMBL. | 21163555 |
MIC (functional) | = 0.125 ug ml-1 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs micro dilution assay | ChEMBL. | 21163555 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.