Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0422 | 0.0295 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0211 | 0.0215 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0808 | 0.0569 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.222 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0422 | 0.0295 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.3466 | 0.3379 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0422 | 0.0174 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.9801 | 0.9798 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0211 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0422 | 0.0431 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0598 | 1 |
Onchocerca volvulus | 0.0027 | 0.0808 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0097 | 0.5254 | 0.5131 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0428 | 0.0301 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0422 | 0.0295 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0808 | 0.0824 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0598 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0422 | 0.0174 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.3217 | 0.3041 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0422 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0422 | 0.0431 |
Schistosoma mansoni | lamin | 0.0027 | 0.0808 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0598 | 0.061 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0169 | 0.9801 | 0.9796 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0097 | 0.5254 | 0.5361 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0598 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.5254 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0296 | 0.0302 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0799 | 0.0815 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0598 | 0.1323 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.0174 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0598 | 0.1323 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0422 | 0.0431 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0598 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.0174 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0422 | 0.0431 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0169 | 0.9801 | 0.9798 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0808 | 0.0686 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0422 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0598 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0211 | 0.0215 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.3656 | 0.3491 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.3656 | 0.373 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0422 | 0.0174 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0422 | 0.0174 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0253 | 0.0124 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0422 | 0.0174 |
Echinococcus granulosus | lamin | 0.0027 | 0.0808 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0211 | 0.0215 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0422 | 0.0174 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.1724 | 0.1509 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.9801 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.3656 | 0.6567 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.3656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1899 | 0.1938 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0502 | 0.0512 |
Loa Loa (eye worm) | IRE protein kinase | 0.0097 | 0.5254 | 0.5361 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0169 | 0.9801 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0422 | 0.0431 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0598 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0808 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0253 | 0.0258 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0422 | 0.0431 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0428 | 0.018 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0808 | 0.0569 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0422 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3983 | 0.4064 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0428 | 0.018 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0422 | 0.0295 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0169 | 0.9801 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0211 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0422 | 0.0431 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0422 | 0.0295 |
Schistosoma mansoni | lamin | 0.0027 | 0.0808 | 0.0686 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0422 | 0.0295 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.9801 | 0.9798 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0422 | 0.0174 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0776 | 0.0792 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0422 | 0.0431 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.0174 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.5254 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1735 | 0.177 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0808 | 0.0569 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0422 | 0.0431 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0598 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0422 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0598 | 0.061 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0598 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.3656 | 0.373 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0422 | 0.0431 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.3656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0635 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0808 | 0.0824 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0422 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.9801 | 0.9798 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.224 | 0.2136 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0253 | 0.0124 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0422 | 0.0431 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0422 | 0.0431 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0808 | 0.0569 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0635 | 0.0391 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0422 | 0.0174 |
Onchocerca volvulus | 0.0027 | 0.0808 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0808 | 0.0569 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0253 | 0.0124 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0598 | 0.061 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0598 | 0.1323 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0169 | 0.9801 | 0.9796 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0422 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0169 | 0.9801 | 0.9796 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0598 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2032 | 0.2073 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0422 | 0.0431 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.3656 | 0.3571 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0211 | 0.0215 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.3217 | 0.3041 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0598 | 0.061 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.3656 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0598 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0422 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0211 | 0.0215 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.3656 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.173 | 0.1765 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0422 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0502 | 0.0376 |
Schistosoma mansoni | apoptosis regulator bax | 0.0169 | 0.9801 | 0.9798 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0808 | 0.0824 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.3656 | 0.3491 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0422 | 0.0174 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0635 | 0.051 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.428 | 0.4367 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Onchocerca volvulus | 0.0024 | 0.0598 | 0.4544 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0808 | 0.0824 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0598 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0422 | 0.0295 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0211 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0422 | 0.0174 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.005 | 0.222 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0253 | 0.0124 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0422 | 0.0295 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0097 | 0.5254 | 0.5131 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1565 | 0.1346 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0422 | 0.0431 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0422 | 0.0431 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0422 | 0.0174 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0422 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1565 | 0.1346 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0422 | 0.0295 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0211 | 0.139 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.1724 | 0.1509 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0422 | 0.0431 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0169 | 0.9801 | 0.9796 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0431 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0598 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0422 | 0.0295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.