Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cruzipain precursor, putative | 0.0438 | 0.484 | 0.484 |
Brugia malayi | cathepsin L-like precursor | 0.0299 | 0.154 | 0.154 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0438 | 0.484 | 0.484 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0268 | 0.0813 | 0.0813 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0268 | 0.0813 | 0.168 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Leishmania major | cysteine peptidase A (CPA) | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0299 | 0.154 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0268 | 0.0813 | 0.0813 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0438 | 0.484 | 0.484 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0299 | 0.154 | 0.154 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0438 | 0.484 | 0.484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0438 | 0.484 | 0.484 |
Echinococcus granulosus | cathepsin l1 | 0.0299 | 0.154 | 0.154 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0438 | 0.484 | 0.484 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0438 | 0.484 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0438 | 0.484 | 0.484 |
Brugia malayi | Cathepsin L-like precursor | 0.0299 | 0.154 | 0.154 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0299 | 0.154 | 0.154 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0268 | 0.0813 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0438 | 0.484 | 1 |
Plasmodium vivax | vivapain-2 | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0299 | 0.154 | 0.3182 |
Loa Loa (eye worm) | fibroinase | 0.0438 | 0.484 | 0.4384 |
Entamoeba histolytica | cysteine protease, putative | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0438 | 0.484 | 0.4384 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.154 | 0.0791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0438 | 0.484 | 0.484 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0299 | 0.154 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0438 | 0.484 | 0.4384 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Toxoplasma gondii | cathepsin CPL | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0299 | 0.154 | 0.154 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Plasmodium vivax | vivapain-2 | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.154 | 0.0791 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0268 | 0.0813 | 0.168 |
Onchocerca volvulus | Cathepsin F homolog | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0438 | 0.484 | 0.4384 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0438 | 0.484 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0438 | 0.484 | 0.4384 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.154 | 0.0791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0438 | 0.484 | 0.484 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0299 | 0.154 | 0.154 |
Giardia lamblia | Cathepsin B precursor | 0.0268 | 0.0813 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0268 | 0.0813 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.484 | 0.4384 |
Onchocerca volvulus | Cathepsin L homolog | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0438 | 0.484 | 0.484 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | <= 20 min | Half life in human hepatocytes | ChEMBL. | 21292480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.