Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0299 | 0.154 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Plasmodium vivax | vivapain-2 | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.484 | 0.4384 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0438 | 0.484 | 0.484 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0299 | 0.154 | 0.154 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0299 | 0.154 | 0.154 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0268 | 0.0813 | 0.168 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0438 | 0.484 | 0.484 |
Toxoplasma gondii | cathepsin CPL | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0438 | 0.484 | 0.484 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0438 | 0.484 | 0.484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0438 | 0.484 | 0.4384 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0299 | 0.154 | 0.3182 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0438 | 0.484 | 0.4384 |
Echinococcus multilocularis | cysteine protease | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0268 | 0.0813 | 0.0813 |
Giardia lamblia | Cathepsin B precursor | 0.0268 | 0.0813 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0299 | 0.154 | 0.154 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0438 | 0.484 | 0.484 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0438 | 0.484 | 0.484 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0438 | 0.484 | 0.484 |
Loa Loa (eye worm) | ctsf protein | 0.0438 | 0.484 | 0.4384 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0268 | 0.0813 | 0.0813 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Echinococcus granulosus | cathepsin l1 | 0.0438 | 0.484 | 0.484 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0438 | 0.484 | 0.4384 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0438 | 0.484 | 0.484 |
Plasmodium vivax | vivapain-2 | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Onchocerca volvulus | 0.0438 | 0.484 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0299 | 0.154 | 0.154 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.154 | 0.0791 |
Giardia lamblia | Cathepsin B precursor | 0.0268 | 0.0813 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.154 | 0.0791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Giardia lamblia | Cathepsin B precursor | 0.0268 | 0.0813 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0299 | 0.154 | 0.154 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0438 | 0.484 | 0.4384 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.154 | 0.0791 |
Echinococcus multilocularis | cysteine protease | 0.0438 | 0.484 | 0.484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0438 | 0.484 | 1 |
Leishmania major | cathepsin L-like protease | 0.0438 | 0.484 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0299 | 0.154 | 0.154 |
Entamoeba histolytica | cysteine protease, putative | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0268 | 0.0813 | 0.168 |
Echinococcus granulosus | cathepsin l1 | 0.0299 | 0.154 | 0.154 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0438 | 0.484 | 0.484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0438 | 0.484 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0299 | 0.154 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | <= 20 min | Half life in human hepatocytes | ChEMBL. | 21292480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.