Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0194 | 0.0038 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | lipase | 0.0283 | 0.067 | 0.067 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.032 | 0.0928 | 0.1649 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1548 | 0.1548 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0407 | 0.1548 | 0.1548 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0283 | 0.067 | 0.2227 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0395 | 0.1463 | 0.5021 |
Onchocerca volvulus | Cathepsin F homolog | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0395 | 0.1463 | 0.2601 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0194 | 0.0038 | 0.0038 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.032 | 0.0928 | 0.1649 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.032 | 0.0928 | 0.3135 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0407 | 0.1548 | 0.3978 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0985 | 0.5624 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1548 | 0.1548 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.032 | 0.0928 | 0.0893 |
Entamoeba histolytica | cysteine protease, putative | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0596 | 0.2876 | 0.2848 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0283 | 0.067 | 0.2227 |
Brugia malayi | Papain family cysteine protease containing protein | 0.032 | 0.0928 | 0.0928 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.032 | 0.0928 | 0.1649 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Trypanosoma cruzi | amidase, putative | 0.0194 | 0.0038 | 0.0068 |
Loa Loa (eye worm) | amidase | 0.0194 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0441 | 0.1781 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0596 | 0.2876 | 0.5113 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0596 | 0.2876 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0985 | 0.5624 | 0.5624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0283 | 0.067 | 0.1192 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0596 | 0.2876 | 0.2876 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0596 | 0.2876 | 0.2848 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0407 | 0.1548 | 0.1548 |
Brugia malayi | putative amidase | 0.0194 | 0.0038 | 0.0038 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0395 | 0.1463 | 0.3594 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0194 | 0.0038 | 0.0068 |
Brugia malayi | Cathepsin L-like precursor | 0.0407 | 0.1548 | 0.1548 |
Giardia lamblia | Cathepsin B precursor | 0.0395 | 0.1463 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0407 | 0.1548 | 0.1548 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Echinococcus granulosus | cysteine protease | 0.032 | 0.0928 | 0.0893 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0283 | 0.067 | 0.0634 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.032 | 0.0928 | 0.3135 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0596 | 0.2876 | 0.2876 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Plasmodium vivax | vivapain-1 | 0.032 | 0.0928 | 0.3226 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0194 | 0.0038 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Plasmodium vivax | vivapain-3 | 0.032 | 0.0928 | 0.3226 |
Echinococcus granulosus | cathepsin l1 | 0.0407 | 0.1548 | 0.1515 |
Loa Loa (eye worm) | ctsf protein | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0596 | 0.2876 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0596 | 0.2876 | 1 |
Brugia malayi | Lipase family protein | 0.0283 | 0.067 | 0.067 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0283 | 0.067 | 0.1192 |
Plasmodium vivax | unspecified product | 0.032 | 0.0928 | 0.3226 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Echinococcus granulosus | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Brugia malayi | Amidase family protein | 0.0194 | 0.0038 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.032 | 0.0928 | 0.0928 |
Giardia lamblia | Cathepsin B precursor | 0.0395 | 0.1463 | 0.5 |
Onchocerca volvulus | 0.0596 | 0.2876 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0441 | 0.1781 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.032 | 0.0928 | 0.3135 |
Echinococcus multilocularis | cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.032 | 0.0928 | 0.1649 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0194 | 0.0038 | 0.5 |
Onchocerca volvulus | 0.0407 | 0.1548 | 0.3978 | |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0407 | 0.1548 | 0.3978 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0395 | 0.1463 | 0.5021 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.032 | 0.0928 | 0.1168 |
Loa Loa (eye worm) | fibroinase | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0596 | 0.2876 | 0.5113 |
Onchocerca volvulus | Cathepsin L homolog | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0596 | 0.2876 | 0.2848 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0596 | 0.2876 | 0.2876 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0283 | 0.067 | 0.0634 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0407 | 0.1548 | 0.1548 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0596 | 0.2876 | 0.2876 |
Echinococcus granulosus | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0407 | 0.1548 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0194 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | cathepsin B | 0.0395 | 0.1463 | 0.1463 |
Onchocerca volvulus | Cathepsin L homolog | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0596 | 0.2876 | 0.2848 |
Leishmania major | hypothetical protein, conserved | 0.0283 | 0.067 | 0.2227 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Echinococcus multilocularis | cathepsin L | 0.032 | 0.0928 | 0.0893 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0194 | 0.0038 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0395 | 0.1463 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0596 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0985 | 0.5624 | 0.5624 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0407 | 0.1548 | 0.2751 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0194 | 0.0038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.1548 | 0.1548 |
Echinococcus multilocularis | cysteine protease | 0.0596 | 0.2876 | 0.2848 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0985 | 0.5624 | 0.5608 |
Plasmodium vivax | vivapain-2 | 0.0596 | 0.2876 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.032 | 0.0928 | 0.0928 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0596 | 0.2876 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0596 | 0.2876 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0194 | 0.0038 | 0.0133 |
Brugia malayi | Amidase family protein | 0.0194 | 0.0038 | 0.0038 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.032 | 0.0928 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.2876 | 0.2876 |
Trypanosoma cruzi | cysteine protease, putative | 0.032 | 0.0928 | 0.1649 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.032 | 0.0928 | 0.0928 |
Brugia malayi | Papain family cysteine protease containing protein | 0.032 | 0.0928 | 0.0928 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0985 | 0.5624 | 0.5624 |
Echinococcus granulosus | cathepsin l1 | 0.0596 | 0.2876 | 0.2848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0596 | 0.2876 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0596 | 0.2876 | 0.2876 |
Loa Loa (eye worm) | amidase | 0.0194 | 0.0038 | 0.0038 |
Echinococcus granulosus | cathepsin L | 0.032 | 0.0928 | 0.0893 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0395 | 0.1463 | 0.1463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.032 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs micro dilution assay | ChEMBL. | 21163555 |
MIC (functional) | = 0.125 ug ml-1 | Antifungal activity against Candida albicans MTCC 3017 after 24 hrs micro dilution assay | ChEMBL. | 21163555 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.