Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cathepsin L-like precursor | 0.0029 | 0.5815 | 0.5815 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0029 | 0.5815 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0029 | 0.5815 | 0.5815 |
Echinococcus granulosus | cathepsin l1 | 0.0029 | 0.5815 | 0.5815 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.1526 | 0.1526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0029 | 0.5815 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0029 | 0.5815 | 0.5815 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0029 | 0.5815 | 0.5815 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0022 | 0.3862 | 0.3862 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0014 | 0.1526 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5815 | 0.5815 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0022 | 0.3862 | 0.3862 |
Brugia malayi | Cathepsin L-like precursor | 0.0029 | 0.5815 | 0.5815 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0029 | 0.5815 | 0.5061 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0014 | 0.1526 | 0.1526 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0014 | 0.1526 | 0.1526 |
Echinococcus granulosus | cathepsin L | 0.0022 | 0.3862 | 0.3862 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5815 | 0.5815 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0029 | 0.5815 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0022 | 0.3862 | 0.3862 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0022 | 0.3862 | 0.3862 |
Onchocerca volvulus | 0.0029 | 0.5815 | 0.5815 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0022 | 0.3862 | 0.2757 |
Schistosoma mansoni | cathepsin s | 0.0014 | 0.1526 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1526 | 0.1526 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0022 | 0.3862 | 0.3862 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0022 | 0.3862 | 0.3862 |
Plasmodium vivax | unspecified product | 0.0022 | 0.3862 | 0.2757 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0022 | 0.3862 | 0.2757 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1526 | 0.1526 |
Echinococcus multilocularis | cathepsin L | 0.0022 | 0.3862 | 0.3862 |
Trypanosoma cruzi | cysteine protease, putative | 0.0022 | 0.3862 | 0.2757 |
Echinococcus granulosus | cysteine protease | 0.0022 | 0.3862 | 0.3862 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0022 | 0.3862 | 0.2757 |
Plasmodium vivax | vivapain-3 | 0.0022 | 0.3862 | 0.2757 |
Plasmodium vivax | vivapain-1 | 0.0022 | 0.3862 | 0.2757 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5815 | 0.5815 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1526 | 0.1526 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.3862 | 0.2757 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 76 % | Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity relative to Dexamethasone | ChEMBL. | 21257309 |
Activity (functional) | = 101 % | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay relative to Dexamethasone | ChEMBL. | 21257309 |
IC50 (functional) | = 5.4 | Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity | ChEMBL. | 21257309 |
IC50 (functional) | = 6.1 | Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay | ChEMBL. | 21257309 |
IC50 (binding) | = 6.8 | Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor | ChEMBL. | 21257309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.