Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0262 | 0.1107 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0398 | 0.4216 | 0.3496 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0398 | 0.4216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1341 | 0.0263 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0272 | 0.1341 | 0.1341 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0398 | 0.4216 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0262 | 0.1107 | 0.1107 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0398 | 0.4216 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0398 | 0.4216 | 0.3496 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0398 | 0.4216 | 0.4216 |
Echinococcus granulosus | cathepsin l1 | 0.0398 | 0.4216 | 0.4216 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0398 | 0.4216 | 0.4216 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0272 | 0.1341 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0398 | 0.4216 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0398 | 0.4216 | 0.4216 |
Loa Loa (eye worm) | ctsf protein | 0.0398 | 0.4216 | 0.3496 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0398 | 0.4216 | 0.4216 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0398 | 0.4216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.4216 | 0.3496 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0272 | 0.1341 | 0.1341 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0398 | 0.4216 | 0.4216 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1341 | 0.0263 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0398 | 0.4216 | 0.4216 |
Plasmodium vivax | vivapain-2 | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0398 | 0.4216 | 1 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0262 | 0.1107 | 0.1107 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0398 | 0.4216 | 0.4216 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0272 | 0.1341 | 0.3182 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0398 | 0.4216 | 0.4216 |
Echinococcus granulosus | cathepsin l1 | 0.0272 | 0.1341 | 0.1341 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0272 | 0.1341 | 0.1341 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0398 | 0.4216 | 0.4216 |
Brugia malayi | Cathepsin L-like precursor | 0.0398 | 0.4216 | 0.4216 |
Giardia lamblia | Cathepsin B precursor | 0.0262 | 0.1107 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0398 | 0.4216 | 0.4216 |
Brugia malayi | Cathepsin L-like precursor | 0.0398 | 0.4216 | 0.4216 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0398 | 0.4216 | 0.4216 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0262 | 0.1107 | 0.2627 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0398 | 0.4216 | 0.3496 |
Brugia malayi | Cathepsin L-like precursor | 0.0398 | 0.4216 | 0.4216 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0262 | 0.1107 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0398 | 0.4216 | 0.4216 |
Loa Loa (eye worm) | cysteine protease | 0.0398 | 0.4216 | 0.3496 |
Brugia malayi | Cathepsin L-like precursor | 0.0398 | 0.4216 | 0.4216 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0398 | 0.4216 | 0.4216 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0272 | 0.1341 | 0.3182 |
Leishmania major | cysteine peptidase A (CPA) | 0.0398 | 0.4216 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0262 | 0.1107 | 0.2627 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0398 | 0.4216 | 0.4216 |
Echinococcus multilocularis | cysteine protease | 0.0398 | 0.4216 | 0.4216 |
Brugia malayi | Cathepsin L-like precursor | 0.0398 | 0.4216 | 0.4216 |
Onchocerca volvulus | 0.0398 | 0.4216 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0398 | 0.4216 | 1 |
Leishmania major | cathepsin L-like protease | 0.0398 | 0.4216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0272 | 0.1341 | 0.1341 |
Brugia malayi | Cathepsin L-like precursor | 0.0398 | 0.4216 | 0.4216 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0398 | 0.4216 | 0.4216 |
Brugia malayi | cathepsin L-like precursor | 0.0272 | 0.1341 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1341 | 0.0263 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0272 | 0.1341 | 0.1341 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0398 | 0.4216 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.