Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.118 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.038 | 0.118 | 0.118 |
Loa Loa (eye worm) | cathepsin B | 0.0391 | 0.1346 | 0.0189 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.118 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0391 | 0.1346 | 0.1346 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0391 | 0.1346 | 0.3631 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Onchocerca volvulus | Cathepsin L homolog | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0391 | 0.1346 | 0.1346 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0554 | 0.3708 | 0.3708 |
Echinococcus granulosus | cathepsin l1 | 0.0554 | 0.3708 | 0.3708 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | ctsf protein | 0.0554 | 0.3708 | 0.2867 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | fibroinase | 0.0554 | 0.3708 | 0.2867 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0554 | 0.3708 | 0.2867 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0554 | 0.3708 | 0.3708 |
Entamoeba histolytica | cysteine proteinase, putative | 0.038 | 0.118 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.038 | 0.118 | 0.118 |
Onchocerca volvulus | Cathepsin L homolog | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0554 | 0.3708 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0554 | 0.3708 | 0.3708 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0554 | 0.3708 | 0.3708 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0391 | 0.1346 | 0.3631 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Plasmodium vivax | vivapain-2 | 0.0554 | 0.3708 | 1 |
Plasmodium vivax | vivapain-2 | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for human neutrophil elastase | ChEMBL. | 21315589 |
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for porcine pancreatic elastase | ChEMBL. | 21315589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.