Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.038 | 0.118 | 0.118 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Entamoeba histolytica | cysteine protease, putative | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.038 | 0.118 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.3708 | 0.2867 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.118 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0554 | 0.3708 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0391 | 0.1346 | 0.1346 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.038 | 0.118 | 0.118 |
Leishmania major | cysteine peptidase A (CPA) | 0.0554 | 0.3708 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0554 | 0.3708 | 0.2867 |
Loa Loa (eye worm) | cathepsin B | 0.0391 | 0.1346 | 0.0189 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0554 | 0.3708 | 0.3708 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.118 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Plasmodium vivax | vivapain-2 | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0554 | 0.3708 | 0.3708 |
Onchocerca volvulus | Cathepsin L homolog | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0391 | 0.1346 | 0.3631 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0554 | 0.3708 | 0.2867 |
Echinococcus multilocularis | cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.038 | 0.118 | 0.118 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0391 | 0.1346 | 0.1346 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.038 | 0.118 | 0.118 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0391 | 0.1346 | 0.3631 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0554 | 0.3708 | 0.3708 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0554 | 0.3708 | 0.2867 |
Plasmodium vivax | vivapain-2 | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for human neutrophil elastase | ChEMBL. | 21315589 |
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for porcine pancreatic elastase | ChEMBL. | 21315589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.