Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | fibroinase | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | ctsf protein | 0.0554 | 0.3708 | 0.2867 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0554 | 0.3708 | 0.3708 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0391 | 0.1346 | 0.1346 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0554 | 0.3708 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0391 | 0.1346 | 0.3631 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.118 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0391 | 0.1346 | 0.1346 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.118 | 0.118 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.038 | 0.118 | 0.118 |
Loa Loa (eye worm) | cathepsin B | 0.0391 | 0.1346 | 0.0189 |
Entamoeba histolytica | cysteine protease, putative | 0.0554 | 0.3708 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.118 | 0.3182 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0554 | 0.3708 | 0.2867 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Plasmodium vivax | vivapain-2 | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Plasmodium vivax | vivapain-2 | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0391 | 0.1346 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like precursor | 0.0554 | 0.3708 | 0.3708 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0554 | 0.3708 | 0.3708 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0391 | 0.1346 | 0.3631 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0554 | 0.3708 | 0.3708 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Leishmania major | cathepsin L-like protease | 0.0554 | 0.3708 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.038 | 0.118 | 0.118 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.038 | 0.118 | 0.3182 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0554 | 0.3708 | 0.3708 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0554 | 0.3708 | 0.3708 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0554 | 0.3708 | 0.2867 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.038 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0554 | 0.3708 | 1 |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | 0.0554 | 0.3708 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0554 | 0.3708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0554 | 0.3708 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0554 | 0.3708 | 0.2867 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for porcine pancreatic elastase | ChEMBL. | 21315589 |
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for human neutrophil elastase | ChEMBL. | 21315589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.