Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | EPH receptor B4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK/EPH protein kinase | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Schistosoma mansoni | ephrin receptor | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Echinococcus granulosus | ephrin type A receptor 4 A | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Onchocerca volvulus | Get druggable targets OG5_126715 | All targets in OG5_126715 | |
Schistosoma japonicum | ko:K05109 Eph receptor A8, putative | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Brugia malayi | ephrin receptor 1 precursor | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Echinococcus multilocularis | ephrin type A receptor 4 A | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1642 | 0.9387 | 0.9379 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.1627 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0298 | 0.1627 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0117 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0117 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0124 | 0.0622 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.1249 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0411 | 0.2037 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0287 | 0.1224 |
Treponema pallidum | recombinase A | 0.0106 | 0.052 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0117 | 0.0173 |
Loa Loa (eye worm) | TK/EPH protein kinase | 0.0085 | 0.0396 | 0.1934 |
Onchocerca volvulus | 0.0066 | 0.0287 | 0.3375 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0261 | 0.0146 |
Chlamydia trachomatis | recombinase RecA | 0.0106 | 0.052 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0117 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0622 | 0.3414 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0088 | 0.0414 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0088 | 0.0414 | 0.2054 |
Entamoeba histolytica | protein kinase, putative | 0.0088 | 0.0414 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.087 | 1 |
Schistosoma mansoni | ephrin receptor | 0.0067 | 0.0291 | 0.2318 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0261 | 0.0955 |
Mycobacterium leprae | RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. | 0.0106 | 0.052 | 0.119 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.0082 | 0.0382 | 0.1756 |
Echinococcus multilocularis | muscleblind protein | 0.0298 | 0.1627 | 1 |
Echinococcus granulosus | dual specificity | 0.0088 | 0.0414 | 0.1967 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0117 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0623 | 0.3504 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0117 | 0.0173 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.0414 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0117 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0414 | 0.2106 |
Mycobacterium ulcerans | recombinase A | 0.0106 | 0.052 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0298 | 0.1627 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0117 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0117 | 0.0108 |
Brugia malayi | Muscleblind-like protein | 0.0298 | 0.1627 | 1 |
Brugia malayi | hypothetical protein | 0.0124 | 0.0622 | 0.3457 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0117 | 0.0173 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0117 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0108 |
Echinococcus multilocularis | dual specificity | 0.0088 | 0.0414 | 0.1967 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.0106 | 0.052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0411 | 0.2037 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0108 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0261 | 0.3577 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0117 | 0.0108 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0117 | 0.0668 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.0414 | 0.3946 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0088 | 0.0414 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0108 |
Echinococcus granulosus | geminin | 0.0167 | 0.087 | 0.4985 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0117 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0108 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0261 | 0.1915 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0622 | 0.3414 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.087 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0261 | 0.4853 |
Entamoeba histolytica | protein kinase, putative | 0.0088 | 0.0414 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0108 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.0082 | 0.0382 | 0.1756 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0261 | 0.3577 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.1627 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0261 | 0.0955 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0261 | 0.3577 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0117 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.087 | 0.4985 |
Entamoeba histolytica | hypothetical protein | 0.0088 | 0.0414 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0261 | 0.1915 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0088 | 0.0414 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0117 | 0.0668 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0261 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0088 | 0.0414 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0124 | 0.0622 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.