Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0129 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.018 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0129 | 0.1672 | 0.1672 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5571 | 0.5571 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.018 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0124 | 0.1296 | 0.1296 |
Loa Loa (eye worm) | alpha-tubulin | 0.018 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.018 | 0.5571 | 0.5571 |
Giardia lamblia | Alpha-tubulin | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0129 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.018 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.018 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.018 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 2 | 0.018 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.018 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0124 | 0.1296 | 0.1296 |
Trypanosoma cruzi | alpha tubulin, putative | 0.018 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.018 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.018 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.5571 | 0.5571 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.018 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.018 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.018 | 0.5571 | 0.5571 |
Schistosoma mansoni | tubulin subunit alpha | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin subunit TubB | 0.018 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.018 | 0.5571 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.018 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0129 | 0.1672 | 0.1672 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.018 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1296 | 0.1296 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.018 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 1 | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.018 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.018 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.018 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0124 | 0.1296 | 0.1296 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0124 | 0.1296 | 0.1296 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.018 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.018 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.018 | 0.5571 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.55 uM | Inhibition of ovine COX2 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassay | ChEMBL. | 21570309 |
IC50 (binding) | = 0.55 uM | Inhibition of ovine COX2 by enzyme immuno assay | ChEMBL. | 22516672 |
IC50 (binding) | > 50 uM | Inhibition of ovine COX1 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassay | ChEMBL. | 21570309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.