Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.4836 | 0.5353 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0246 | 0.9034 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0944 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.4836 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0246 | 0.9034 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.4836 | 0.5353 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0944 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0854 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.9034 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0246 | 0.9034 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0944 | 0.5 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0944 | 0.1953 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0854 | 0.1767 |
Onchocerca volvulus | 0.0042 | 0.0944 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.9034 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0944 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.1591 | 0.1761 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0854 | 0.0946 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0944 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0944 | 0.1045 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1591 | 0.1761 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0944 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0944 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0944 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.0944 | 0.5 | |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0944 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.1591 | 0.3289 |
Echinococcus multilocularis | serotonin receptor | 0.0246 | 0.9034 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0944 | 0.1045 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0944 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0944 | 0.1953 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0944 | 0.1045 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0944 | 0.1045 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0944 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0944 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0944 | 0.1045 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0944 | 0.1045 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0944 | 0.1045 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0944 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0944 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0944 | 0.1045 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0944 | 0.1045 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0944 | 0.1045 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0944 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0944 | 0.1045 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0944 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0944 | 0.1045 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.1591 | 0.3289 |
Onchocerca volvulus | 0.0042 | 0.0944 | 0.5 | |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0944 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Antagonist activity at human CD36-oxLDL binding at 10 uM after 2 hrs by ELISA | ChEMBL. | 21295889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.