Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.0196 | 0.0559 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0907 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0864 | 0.1374 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0907 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0907 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2498 | 0.3976 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.023 | 0.0739 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.0196 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.0196 | 0.0559 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0864 | 0.4094 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0864 | 0.0149 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0907 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0864 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0196 | 0.0415 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0907 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.0196 | 0.0559 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0864 | 0.4094 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0864 | 0.1097 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.0196 | 0.0415 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0772 | 0.2681 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0196 | 0.0559 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0772 | 0.1228 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0907 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0.6284 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0196 | 0.0311 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0196 | 0.0559 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0864 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0864 | 0.1374 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0864 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0772 | 0.3608 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.0196 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0196 | 0.0559 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.0196 | 0.0559 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.0196 | 0.0415 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0341 | 0.0239 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.0196 | 0.0415 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.0196 | 0.0415 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.0196 | 0.0559 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.0196 | 0.0415 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0772 | 0.3608 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0772 | 0.2681 |
Onchocerca volvulus | 0.0152 | 0.6284 | 1 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.086 | 0.4076 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0196 | 0.0559 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0907 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0864 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.1979 | 1 |
Onchocerca volvulus | 0.0036 | 0.0864 | 0.1097 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.1979 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0772 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0864 | 0.1374 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0864 | 0.0149 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0196 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0196 | 0.0311 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.023 | 0.055 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.014 | 0.0196 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0907 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.4236 | 0.6637 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.0196 | 0.0311 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.0196 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0864 | 0.1374 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0907 | 0.4326 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0864 | 0.0149 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0196 | 0.0415 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0772 | 0.3608 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0196 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0864 | 0.1374 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.2633 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0864 | 0.3043 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0864 | 0.1097 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0907 | 0.3215 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0907 | 0.4326 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0196 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1176 | 0.1872 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0772 | 0.1228 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0864 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0864 | 0.1374 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0864 | 0.1097 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0864 | 0.1097 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0772 | 0.2681 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.4236 | 0.6741 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0907 | 0.3215 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0772 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.6284 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0772 | 0.3608 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0864 | 0.3043 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0864 | 0.1374 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0196 | 0.0311 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2148 | 0.8094 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.2633 | 0.4003 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.0196 | 0.0311 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.0196 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2633 | 0.4189 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0907 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0864 | 0.0149 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0864 | 0.0149 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.5738 | 0.9131 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0864 | 0.0149 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0196 | 0.0559 |
Onchocerca volvulus | 0.0036 | 0.0864 | 0.1097 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0772 | 0.3608 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.0196 | 0.0559 |
Onchocerca volvulus | 0.0036 | 0.0864 | 0.1097 | |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0907 | 0.1444 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0907 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.0196 | 0.0559 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0907 | 0.1169 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0196 | 0.0311 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0972 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0196 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0975 | 0.1552 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.014 | 0.0222 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0196 | 0.0559 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0864 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0196 | 0.0415 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0864 | 0.1374 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0772 | 0.3608 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.27 | 0.4113 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.086 | 0.4076 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.023 | 0.0739 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0772 | 0.2681 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.4236 | 0.6637 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.5738 | 0.9103 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.5738 | 0.9131 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.4236 | 0.6741 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0196 | 0.0559 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0864 | 0.0149 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.0196 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1086 | 0.1729 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0196 | 0.0559 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0196 | 0.0311 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0196 | 0.0559 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay | ChEMBL. | 21441024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.