Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2298 | 0.7095 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.0227 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.3192 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.1267 | 0.3968 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.2298 | 0.7095 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.1267 | 0.3968 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.1267 | 0.3968 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.4627 | 0.5 |
Brugia malayi | RNA binding protein | 0.0134 | 0.3192 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.1143 | 0.3582 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.1267 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0227 | 0.0969 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.2298 | 0.7201 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0479 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.2903 | 0.9061 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1143 | 0.334 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.2903 | 0.9061 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.2298 | 0.7201 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.1267 | 0.3968 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.3192 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.1267 | 0.3968 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.1267 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.402 | 0.3871 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.3192 | 1 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.1267 | 0.3968 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.0116 | 0.0362 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.3192 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.3192 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0077 | 0.1267 | 0.3968 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3192 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 0.1267 | 0.3741 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.3192 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.3192 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3192 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3192 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3192 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.402 | 0.3871 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0593 | 0.0358 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.4627 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3192 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0227 | 0.0969 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.2903 | 0.9095 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1143 | 0.3582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to human vasopressin V1a receptor expressed CHO cells at up to 500 nM after 1 hr by spectrofluorimetry analysis | ChEMBL. | 21428295 | |
EC50 (functional) | = 6.93 nM | Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay | ChEMBL. | 21428295 |
Emax (functional) | = 93.1 % | Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay relative to arginine vasopressin | ChEMBL. | 21428295 |
Ki (binding) | = 1.2 nM | Displacement of [3H]AVP from human vasopressin V1b receptor expressed CHO cells after 60 mins | ChEMBL. | 21428295 |
Ki (binding) | = 30 nM | Displacement of [3H]AVP from human oxytocin receptor expressed CHO cells after 60 mins | ChEMBL. | 21428295 |
Ki (binding) | = 258 nM | Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins | ChEMBL. | 21428295 |
Ki (binding) | > 100000 nM | Displacement of [3H]AVP from human vasopressin V2 receptor expressed CHO cells after 60 mins | ChEMBL. | 21428295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.