Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0295 | 0.2541 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.3687 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0295 | 0.2541 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.4508 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.5123 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0344 | 0.1355 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0533 | 0.5291 | 0.3687 |
Brugia malayi | Probable DNA topoisomerase II | 0.0295 | 0.2541 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0295 | 0.2541 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0295 | 0.2541 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0295 | 0.2541 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0295 | 0.2541 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0295 | 0.2541 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0295 | 0.2541 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0237 | 0.1869 | 0.7355 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0295 | 0.2541 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.5123 |
Schistosoma mansoni | DNA topoisomerase II | 0.0295 | 0.2541 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.027 | 0.2246 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0652 | 0.2564 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0295 | 0.2541 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0295 | 0.2541 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0295 | 0.2541 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0409 | 0.3862 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0295 | 0.2541 | 0.1404 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0652 | 0.2564 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0237 | 0.1869 | 0.7355 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0533 | 0.5291 | 0.4508 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0295 | 0.2541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.2009 | 0.7903 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0344 | 0.1355 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0295 | 0.2541 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | Competitive inhibition of human ASK1 | ChEMBL. | 21449566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.