Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1236 | 0.8309 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0334 | 0.1488 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0334 | 0.1488 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0334 | 0.1488 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0602 | 0.4585 | 0.3639 |
Giardia lamblia | DNA topoisomerase II | 0.0305 | 0.1155 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0334 | 0.1488 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0334 | 0.1488 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0334 | 0.1488 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0334 | 0.1488 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1236 | 0.8309 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0334 | 0.1488 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1236 | 0.8309 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0334 | 0.1488 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.0127 | 0.0854 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0602 | 0.4585 | 0.3639 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0334 | 0.1488 | 0.1388 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0334 | 0.1488 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0334 | 0.1488 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0334 | 0.1488 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0334 | 0.1488 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0334 | 0.1488 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1236 | 0.8309 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0472 | 0.3087 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.0127 | 0.0854 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1236 | 0.8309 |
Schistosoma mansoni | DNA topoisomerase II | 0.0334 | 0.1488 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0334 | 0.1488 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1236 | 0.8309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | Inhibition of recombinant glucocerebrosidase in McIlvaine buffer at pH 5.2 after 10 mins by fluorometric analysis | ChEMBL. | 21370884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.