Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA topoisomerase II | 0.0331 | 0.2284 | 0.9195 |
Echinococcus granulosus | snurportin 1 | 0.0343 | 0.2403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0491 | 0.082 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.062 | 0.5052 | 0.3588 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0343 | 0.2403 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0343 | 0.2403 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0331 | 0.2284 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0331 | 0.2284 | 0.9195 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0331 | 0.2284 | 0.9195 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.2403 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0331 | 0.2284 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0303 | 0.2021 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0331 | 0.2284 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.062 | 0.5052 | 0.4889 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0374 | 0.2698 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.062 | 0.5052 | 0.3588 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0374 | 0.2698 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0374 | 0.2698 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0374 | 0.2698 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0331 | 0.2284 | 0.9431 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0577 | 0.4639 | 0.4462 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0331 | 0.2284 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0331 | 0.2284 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0331 | 0.2284 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0331 | 0.2284 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0331 | 0.2284 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0331 | 0.2284 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0491 | 0.082 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0509 | 0.399 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 4.1 % | Inhibition of MAO-B (unknown origin) assessed as residual activity | ChEMBL. | 24169316 |
IC50 (binding) | = 1.68 | Inhibition of MAO-B (unknown origin) | ChEMBL. | 24169316 |
IC50 (binding) | = 20.69 uM | Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method | ChEMBL. | 21405131 |
Inhibition (binding) | Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production at 100 uM by fluorimetric method | ChEMBL. | 21405131 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.