Detailed information for compound 1509810

Basic information

Technical information
  • TDR Targets ID: 1509810
  • Name: (5R,6R,7S,8S)-5-(hydroxymethyl)-5,6,7,8-tetra hydroimidazo[2,1-f]pyridine-6,7,8-triol
  • MW: 200.192 | Formula: C8H12N2O4
  • H donors: 4 H acceptors: 5 LogP: -2.43 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@H](c2n1ccn2)O
  • InChi: 1S/C8H12N2O4/c11-3-4-5(12)6(13)7(14)8-9-1-2-10(4)8/h1-2,4-7,11-14H,3H2/t4-,5-,6+,7-/m1/s1
  • InChiKey: RZRDQZQPTISYKY-MVIOUDGNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5R,6R,7S,8S)-5-methylol-5,6,7,8-tetrahydroimidazo[2,1-f]pyridine-6,7,8-triol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0074 0.0001
Brugia malayi SH2 domain containing protein 0.001 0.0128 0.0207
Schistosoma mansoni tensin-related 0.0008 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1691 0.163
Onchocerca volvulus 0.0008 0.0077 0.0044
Brugia malayi Protein kinase domain containing protein 0.001 0.0128 0.0207
Brugia malayi STAT protein, DNA binding domain containing protein 0.0008 0.0077 0.0119
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0008 0.0077 0.0004
Echinococcus granulosus SH2 motif 0.0008 0.0077 0.0004
Echinococcus multilocularis SHC transforming protein 3 0.0008 0.0077 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1403 0.1403
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0074 0.0074
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Onchocerca volvulus 0.0008 0.0077 0.0044
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.2847 0.4953
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0076 0.1691 0.163
Brugia malayi Spectrin alpha chain 0.0007 0.0073 0.0111
Onchocerca volvulus 0.005 0.1089 1
Onchocerca volvulus 0.0008 0.0077 0.0044
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0076 0.1691 0.163
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0303 0.0231
Echinococcus multilocularis cpg binding protein 0.0032 0.0648 0.0579
Schistosoma mansoni suppressor of cytokine signaling 0.0008 0.0077 0.0077
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0008 0.0077 0.0077
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0252 0.0181
Echinococcus granulosus SH2 motif 0.0008 0.0077 0.0004
Brugia malayi Protein kinase domain containing protein 0.001 0.0128 0.0207
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1398 0.1335
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0073 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0099 0.0157
Schistosoma mansoni GTPase activating protein 0.0008 0.0077 0.0077
Entamoeba histolytica protein kinase, putative 0.0061 0.1337 1
Schistosoma mansoni sorting nexin 0.0007 0.0073 0.0073
Echinococcus granulosus tyrosine protein kinase Src42A 0.0076 0.1691 0.163
Schistosoma mansoni suppressor of cytokine signaling 0.0008 0.0077 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0073 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0061 0.1337 0.1273
Echinococcus multilocularis tyrosine protein kinase Blk 0.0068 0.1516 0.1454
Echinococcus multilocularis tyrosine protein kinase ABL1 0.001 0.0128 0.0055
Brugia malayi hypothetical protein 0.0246 0.5738 1
Echinococcus granulosus signal transduction protein lnk realted 0.0008 0.0077 0.0004
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0252 0.0424
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0074 0.0001
Schistosoma mansoni tensin-related 0.0008 0.0077 0.0077
Brugia malayi SH3 domain containing protein 0.0007 0.0073 0.0111
Echinococcus granulosus tyrosine protein kinase shark 0.001 0.0128 0.0055
Onchocerca volvulus 0.003 0.0608 0.5259
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1398 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0252 0.0252
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0007 0.0073 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0008 0.0077 0.0004
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0008 0.0077 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Onchocerca volvulus 0.001 0.0128 0.0539
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0252 0.0424
Brugia malayi Protein kinase domain containing protein 0.001 0.0128 0.0207
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0073 0.0111
Echinococcus multilocularis SH2 motif 0.0008 0.0077 0.0004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.1516 0.1454
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1398 0.5
Echinococcus multilocularis SH2 motif 0.0008 0.0077 0.0004
Brugia malayi CXXC zinc finger family protein 0.003 0.0608 0.1044
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0007 0.0073 0.0073
Echinococcus multilocularis tensin 0.0008 0.0077 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) guanylate kinase 0.0007 0.0073 0.0111
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0008 0.0077 0.0119
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0157
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0252 0.0424
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Schistosoma mansoni hypothetical protein 0.0007 0.0073 0.0073
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0099 0.0157
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0007 0.0073 0.0073
Onchocerca volvulus 0.001 0.0128 0.0539
Schistosoma mansoni tyrosine kinase 0.001 0.0128 0.0128
Onchocerca volvulus 0.001 0.0128 0.0539
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Schistosoma mansoni tensin 0.0008 0.0077 0.0077
Echinococcus multilocularis signal transduction protein lnk realted 0.0008 0.0077 0.0004
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0008 0.0077 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.2847 0.4953
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0303 0.0231
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) TK protein kinase 0.0061 0.1337 0.2317
Schistosoma mansoni tyrosine kinase 0.0076 0.1691 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0252 0.0181
Loa Loa (eye worm) Smad1 0.0008 0.0099 0.0157
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0076 0.1691 0.163
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1691 0.163
Echinococcus granulosus tyrosine protein kinase Src64B 0.0076 0.1691 0.163
Schistosoma mansoni smad 0.0008 0.0099 0.0099
Schistosoma mansoni tensin 0.0008 0.0077 0.0077
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0303 0.0231
Brugia malayi RhoGAP domain containing protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0118 0.0189
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.5738 0.5707
Echinococcus multilocularis 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine protein kinase ABL1 0.001 0.0128 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Schistosoma mansoni Smad4 0.0008 0.0099 0.0099
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Brugia malayi Tensin 0.0008 0.0077 0.0119
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0157
Echinococcus multilocularis tyrosine protein kinase Srms 0.0068 0.1516 0.1454
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Echinococcus multilocularis tyrosine kinase 0.001 0.0128 0.0055
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0045
Schistosoma mansoni cell polarity protein 0.0007 0.0073 0.0073
Schistosoma mansoni tyrosine kinase 0.001 0.0128 0.0128
Echinococcus granulosus NCK adaptor protein 0.0015 0.0252 0.0181
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0252 0.0181
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0608 0.1044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0074 0.0001
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0252 0.0424
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0073 0.0111
Loa Loa (eye worm) TK protein kinase 0.0068 0.1516 0.263
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Echinococcus granulosus tyrosine protein kinase Blk 0.0068 0.1516 0.1454
Echinococcus granulosus SHC transforming protein 3 0.0008 0.0077 0.0004
Loa Loa (eye worm) TK/ABL protein kinase 0.001 0.0128 0.0207
Schistosoma mansoni shc transforming protein 0.0008 0.0077 0.0077
Schistosoma mansoni cpg binding protein 0.003 0.0608 0.0608
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0073 0.0111
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0303 0.0231
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Trichomonas vaginalis p67phox protein, putative 0.0007 0.0073 1
Brugia malayi hypothetical protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Schistosoma mansoni tensin 0.0008 0.0077 0.0077
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine kinase 0.0068 0.1516 0.1454
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0008 0.0077 0.0044
Onchocerca volvulus 0.0008 0.0077 0.0044
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0076 0.1691 0.163
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0007 0.0073 0.0073
Schistosoma mansoni C-fyn 0.0007 0.0073 0.0073
Echinococcus granulosus hypothetical protein 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1691 0.163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0007 0.0073 1
Echinococcus granulosus tensin 0.0008 0.0077 0.0004
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Loa Loa (eye worm) hypothetical protein 0.0246 0.5738 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0008 0.0077 0.0119
Brugia malayi cytokine inducible SH2-containing protein 5 0.0008 0.0077 0.0119
Loa Loa (eye worm) STAT protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Onchocerca volvulus 0.0008 0.0077 0.0044
Brugia malayi Protein kinase domain containing protein 0.001 0.0128 0.0207
Brugia malayi Peripheral plasma membrane protein CASK 0.0007 0.0073 0.0111
Schistosoma mansoni dynamin-associated protein 0.0007 0.0073 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0007 0.0073 0.0073
Entamoeba histolytica SH2 domain containing protein 0.0008 0.0077 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) p53BP2 0.0007 0.0073 0.0111
Echinococcus multilocularis smad 0.0008 0.0099 0.0026
Schistosoma mansoni tyrosine kinase 0.0076 0.1691 0.1691
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Echinococcus granulosus tyrosine protein kinase Fps85D 0.001 0.0128 0.0055
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0068 0.1516 0.1454
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0115 0.0184
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0073 0.0111
Schistosoma mansoni nck2/grb4 0.0015 0.0252 0.0252
Echinococcus granulosus N chimaerin 0.0008 0.0077 0.0004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.1691 0.163
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0303 0.0303
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1398 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0008 0.0077 0.0004
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0008 0.0077 0.0004
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0008 0.0077 0.0044
Echinococcus multilocularis tensin 0.0008 0.0077 0.0004
Onchocerca volvulus 0.001 0.0128 0.0539
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.5738 0.5707
Echinococcus granulosus cpg binding protein 0.0032 0.0648 0.0579
Echinococcus granulosus SH2 domain containing adapter protein F 0.0008 0.0077 0.0004
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0007 0.0073 0.0111
Schistosoma mansoni run and tbc1 domain containing 0.0007 0.0073 0.0073
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.1466 0.1403
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0303 0.0512
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0008 0.0077 0.0119
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1691 0.163
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.001 0.0128 0.0055
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0076 0.1691 0.163
Echinococcus multilocularis tyrosine protein kinase shark 0.001 0.0128 0.0055
Entamoeba histolytica protein kinase, putative 0.0008 0.0077 0.0035
Brugia malayi Myosin tail family protein 0.0007 0.0073 0.0111
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Schistosoma mansoni Dab2-interacting protein-like 0.0007 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0008 0.0077 0.0004
Echinococcus granulosus suppressor of cytokine signaling 6 0.0008 0.0077 0.0004
Loa Loa (eye worm) SRC-1 0.0076 0.1691 0.2935
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Brugia malayi tRNA modification GTPase TrmE family protein 0.0008 0.0077 0.0119
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0077 0.0119
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0007 0.0073 0.0073
Onchocerca volvulus 0.0008 0.0077 0.0044
Loa Loa (eye worm) protein-tyrosine kinase 0.0007 0.0073 0.0111
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0008 0.0077 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0076 0.1691 0.163
Onchocerca volvulus 0.001 0.0128 0.0539
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0077 0.0077
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1398 0.1335
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0076 0.1691 0.163
Brugia malayi Guanylate kinase family protein 0.0007 0.0073 0.0111
Brugia malayi Src substrate cortactin 0.0007 0.0073 0.0111
Schistosoma mansoni hypothetical protein 0.0008 0.0077 0.0077
Schistosoma mansoni vav2 0.0008 0.0077 0.0077
Schistosoma mansoni adapter molecule crk 0.0015 0.0252 0.0252
Brugia malayi Protein kinase domain containing protein 0.001 0.0128 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1398 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0008 0.0077 0.0077
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0303 0.0231
Echinococcus granulosus tyrosine protein kinase HCK 0.0061 0.1337 0.1273
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0099 0.0026
Schistosoma mansoni survival motor neuron protein 0.005 0.1089 0.1089
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0252 0.0424
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0073 0.0111
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0252 0.0424
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Echinococcus granulosus suppressor of cytokine signaling 7 0.0008 0.0077 0.0004
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0077 0.0119
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0099 0.0026
Echinococcus granulosus tyrosine protein kinase Srms 0.001 0.0128 0.0055
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0073 0.0111
Entamoeba histolytica SH2-protein kinase domain containing protein 0.001 0.0128 0.0433
Onchocerca volvulus 0.001 0.0128 0.0539
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0008 0.0077 0.0035
Brugia malayi protein-tyrosine kinase 0.0068 0.1516 0.263
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0157
Echinococcus multilocularis Smad4 0.0008 0.0099 0.0026
Schistosoma mansoni SH2A 0.0008 0.0077 0.0077
Trypanosoma brucei conserved protein 0.0007 0.0073 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0073 0.5
Echinococcus granulosus expressed conserved protein 0.0008 0.0077 0.0004
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0252 0.0252
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0008 0.0077 0.0119
Schistosoma mansoni hypothetical protein 0.005 0.1089 0.1089
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0099 0.0099
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0077 0.0119
Schistosoma mansoni eps8-related protein 0.0007 0.0073 0.0073
Echinococcus granulosus tyrosine kinase 0.001 0.0128 0.0055
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0076 0.1691 0.163
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0157
Schistosoma mansoni formin binding protein and related proteins 0.0007 0.0073 0.0073
Echinococcus granulosus SH2 domain containing protein 7 0.0008 0.0077 0.0004
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Schistosoma mansoni tyrosine kinase 0.0017 0.0303 0.0303
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1089 0.1885
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Brugia malayi Fes/CIP4 homology domain containing protein 0.0007 0.0073 0.0111
Brugia malayi protein-tyrosine kinase 0.0007 0.0073 0.0111
Echinococcus multilocularis SH2 motif 0.0008 0.0077 0.0004
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0076 0.1691 0.163
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1398 0.1398
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0045
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0074 0.0001
Schistosoma mansoni cpg binding protein 0.0032 0.0648 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Echinococcus granulosus Smad4 0.0008 0.0099 0.0026
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0099 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1398 0.5
Brugia malayi SRC-1 0.0076 0.1691 0.2935
Echinococcus granulosus tyrosine protein kinase Lyn 0.0076 0.1691 0.163
Brugia malayi MH2 domain containing protein 0.0124 0.2847 0.4953
Echinococcus multilocularis N chimaerin 0.0008 0.0077 0.0004
Schistosoma mansoni signal transduction protein lnk-related 0.0008 0.0077 0.0077
Schistosoma mansoni cpg binding protein 0.0032 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0077 0.0119
Loa Loa (eye worm) hypothetical protein 0.0008 0.0077 0.0119
Brugia malayi SH2 domain containing protein 0.0008 0.0077 0.0119
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0008 0.0077 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 1
Echinococcus granulosus smad 0.0008 0.0099 0.0026
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0099 0.0026
Brugia malayi hypothetical protein 0.001 0.0128 0.0207
Schistosoma mansoni apoptosis stimulating of P53 0.0007 0.0073 0.0073
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0252 0.0252
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0073 0.0111
Schistosoma mansoni tyrosine kinase 0.0017 0.0303 0.0303
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0008 0.0077 0.0004
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.1466 0.1403
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0128 0.0207
Schistosoma mansoni dreadlocks/dock 0.0007 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0128 0.0207
Schistosoma mansoni hypothetical protein 0.0008 0.0077 0.0077
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1398 0.5
Brugia malayi SH2 domain containing protein 0.001 0.0128 0.0207
Schistosoma mansoni sorbin 0.0007 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0007 0.0073 0.0111
Loa Loa (eye worm) thyroid receptor interactor 0.0007 0.0073 0.0111
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0008 0.0077 0.0004
Brugia malayi Smad1 0.0008 0.0099 0.0157
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1398 0.1398
Loa Loa (eye worm) SH2 domain-containing protein 0.0008 0.0077 0.0119

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 6.2 % Inhibition of human OGA at 100 uM ChEMBL. 23058883

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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