Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.012 | 0.1296 | 0.1296 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.012 | 0.1296 | 0.1296 |
Brugia malayi | alpha-tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.5571 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 2 | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0125 | 0.1672 | 0.1672 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0174 | 0.5571 | 0.5571 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0125 | 0.1672 | 0.1672 |
Giardia lamblia | Alpha-tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Plasmodium falciparum | alpha tubulin 1 | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0174 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0125 | 0.1672 | 0.1672 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.012 | 0.1296 | 0.1296 |
Brugia malayi | Tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0174 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0174 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0174 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0174 | 0.5571 | 0.5571 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0174 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0125 | 0.1672 | 0.1672 |
Schistosoma mansoni | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0174 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0174 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.012 | 0.1296 | 0.1296 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1296 | 0.1296 |
Trypanosoma brucei | alpha tubulin | 0.0174 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0174 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0174 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5571 | 0.5571 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0174 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.0174 | 0.5571 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 100 uM | Cytotoxicity against human THP1 cells using cell count reagent SF | ChEMBL. | 21524580 |
ED50 (functional) | > 100 uM | Immunomodulatory activity in human THP1 cells assessed as differentiation of monocyte to macrophage after 4 days by MTT assay | ChEMBL. | 21524580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.