Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3537 | 0.3537 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.3039 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.3537 | 0.3537 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0375 | 0.0375 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.3039 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.3039 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.3537 | 0.6116 |
Onchocerca volvulus | 0.0031 | 0.3537 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0031 | 0.3537 | 0.3537 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.3039 | 0.5 |
Brugia malayi | hypothetical protein | 0.0029 | 0.3039 | 0.3039 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0516 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3039 | 0.3039 |
Echinococcus multilocularis | musashi | 0.0031 | 0.3537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.5545 | 0.5545 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.3039 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.3039 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.3039 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.3537 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.5545 | 0.5545 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.3039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0375 | 0.0375 |
Echinococcus granulosus | lamin | 0.0031 | 0.3537 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.3537 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.3537 | 0.6116 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5545 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.3537 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.3537 | 0.3537 |
Schistosoma mansoni | lamin | 0.0031 | 0.3537 | 0.6116 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.3537 | 0.3537 |
Onchocerca volvulus | 0.0031 | 0.3537 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3397 | 0.3397 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.3537 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 150 uM | Ex vivo immunosuppressive activity in Drosophila larvae assessed as inhibition of IMD signaling pathway by beta-galactosidase reporter gene assay | ChEMBL. | 21334120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.