Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.2762 | 0.8779 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0056 | 0.0921 | 0.1568 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0056 | 0.0921 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0112 | 0.2971 | 0.9467 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0056 | 0.0921 | 0.1568 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.1531 | 0.4716 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0788 | 0.1312 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0056 | 0.0921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0297 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2762 | 0.8779 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0089 | 0.2148 | 0.7229 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0052 | 0.0779 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0056 | 0.0921 | 0.2702 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0379 | 0.0529 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0089 | 0.2148 | 0.3917 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0052 | 0.0779 | 0.0416 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.0654 | 0.1822 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0779 | 0.2233 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0112 | 0.2971 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0379 | 0.0911 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0059 | 0.1019 | 0.1957 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0148 | 0.4308 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0059 | 0.1019 | 0.2365 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.0921 | 0.1568 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0089 | 0.2148 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 0.2148 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.0921 | 0.1568 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0059 | 0.1019 | 0.1755 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.0654 | 0.1822 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0779 | 0.2233 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0112 | 0.2971 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.2971 | 0.5494 |
Schistosoma mansoni | coup transcription factor | 0.0056 | 0.0921 | 0.1568 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0056 | 0.0921 | 0.1568 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0112 | 0.2971 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0112 | 0.2971 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.2762 | 0.8779 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0779 | 0.2233 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.5323 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Onchocerca volvulus | 0.0056 | 0.0921 | 1 | |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0112 | 0.2971 | 0.9467 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.0779 | 0.0416 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0788 | 0.1312 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0056 | 0.0921 | 0.1568 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0056 | 0.0921 | 0.1568 |
Trypanosoma brucei | protein kinase, putative | 0.0112 | 0.2971 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.0921 | 0.1568 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0056 | 0.0921 | 0.1568 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0379 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2148 | 0.675 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0112 | 0.2971 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0049 | 0.0654 | 0.0892 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0779 | 0.0537 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.0921 | 0.1568 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0056 | 0.0921 | 0.2702 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.0779 | 0.1808 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0056 | 0.0921 | 0.2702 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0112 | 0.2971 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0779 | 0.1202 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0779 | 0.137 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0148 | 0.4308 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0148 | 0.4308 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.5323 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0116 | 0.3132 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0297 | 0.0641 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.0654 | 0.1822 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0056 | 0.0921 | 0.2702 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.0921 | 0.1568 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0056 | 0.0921 | 0.2702 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0112 | 0.2971 | 0.5494 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0788 | 0.2261 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0056 | 0.0921 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.0921 | 0.1568 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0059 | 0.1019 | 0.1957 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 0.4615 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0056 | 0.0921 | 0.1568 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0056 | 0.0921 | 0.2702 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0112 | 0.2971 | 0.5494 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0112 | 0.2971 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0788 | 0.1312 |
Brugia malayi | ecdysteroid receptor | 0.0056 | 0.0921 | 0.2702 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0779 | 0.0537 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0056 | 0.0921 | 0.1568 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0052 | 0.0779 | 0.1202 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0056 | 0.0921 | 0.1568 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0788 | 0.1312 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0379 | 0.0529 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0059 | 0.1019 | 0.1755 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0788 | 0.1312 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 0.3917 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0788 | 0.1312 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0089 | 0.2148 | 0.7229 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0779 | 0.1202 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.0654 | 0.1822 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0788 | 0.2261 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0112 | 0.2971 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0056 | 0.0921 | 0.1568 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0056 | 0.0921 | 0.1568 |
Brugia malayi | nuclear hormone receptor | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0297 | 0.0641 |
Echinococcus granulosus | geminin | 0.0176 | 0.5323 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0056 | 0.0921 | 0.1568 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0779 | 0.1202 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0056 | 0.0921 | 0.2702 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 0.4615 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.0921 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0297 | 0.0641 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0056 | 0.0921 | 0.1568 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0779 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.2762 | 0.8779 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0056 | 0.0921 | 0.2702 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 0.3917 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0056 | 0.0921 | 0.2702 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0056 | 0.0921 | 0.1568 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0112 | 0.2971 | 0.5494 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0049 | 0.0654 | 0.1822 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.0921 | 0.1568 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0112 | 0.2971 | 0.5494 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0052 | 0.0779 | 0.1202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0056 | 0.0921 | 0.2702 |
Echinococcus multilocularis | geminin | 0.0176 | 0.5323 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1531 | 0.2737 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0052 | 0.0779 | 0.137 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0779 | 0.2233 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0089 | 0.2148 | 0.4985 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0052 | 0.0779 | 0.1202 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0056 | 0.0921 | 0.2702 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.0779 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0297 | 0.0641 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0056 | 0.0921 | 0.2702 |
Schistosoma mansoni | thyroid hormone receptor | 0.0056 | 0.0921 | 0.1568 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0056 | 0.0921 | 0.1568 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.0921 | 0.1568 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0056 | 0.0921 | 0.2702 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0056 | 0.0921 | 0.2702 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.2148 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.0297 | 0.019 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.0779 | 0.1808 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0116 | 0.3132 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0056 | 0.0921 | 0.1568 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0379 | 0.0529 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0779 | 0.2233 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.0297 | 0.1381 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.0921 | 0.1568 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.0297 | 0.1381 |
Brugia malayi | nuclear receptor NHR-88 | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0779 | 0.2233 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0056 | 0.0921 | 0.1568 |
Brugia malayi | steroid hormone receptor | 0.0056 | 0.0921 | 0.2702 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0788 | 0.1312 |
Brugia malayi | Probable ClpP-like protease | 0.0089 | 0.2148 | 0.675 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0056 | 0.0921 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0921 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1531 | 0.4716 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0779 | 0.1202 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0056 | 0.0921 | 0.1568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.