Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium channel protein | 0.0055 | 0.0677 | 0.0762 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7302 | 0.8211 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0051 | 0.0335 | 0.0335 |
Echinococcus granulosus | voltage gated potassium channel | 0.0051 | 0.0335 | 0.0377 |
Echinococcus multilocularis | serotonin transporter | 0.0132 | 0.6291 | 0.7074 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0055 | 0.0677 | 0.0762 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0051 | 0.0335 | 0.0377 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0154 | 0.789 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0132 | 0.6291 | 0.7074 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0167 | 0.8893 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0132 | 0.6291 | 0.7074 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0167 | 0.8893 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0132 | 0.6291 | 0.7074 |
Onchocerca volvulus | 0.0132 | 0.6291 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0335 | 0.0377 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0051 | 0.0335 | 0.0335 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0132 | 0.6291 | 0.7074 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0051 | 0.0335 | 0.0377 |
Echinococcus granulosus | sodium channel protein | 0.0055 | 0.0677 | 0.0762 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0132 | 0.6291 | 0.6291 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0154 | 0.789 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0132 | 0.6291 | 0.6291 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6291 | 0.7074 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0051 | 0.0335 | 0.0377 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0051 | 0.0335 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6291 | 0.7074 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0132 | 0.6291 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0055 | 0.0677 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0132 | 0.6291 | 0.7074 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0167 | 0.8893 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6291 | 0.7074 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0167 | 0.8893 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells co-expressing VIP-luciferase by scintillation counting-based whole cell binding assay | ChEMBL. | 21596563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.