Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated potassium channel | 0.0072 | 0.1192 | 0.1325 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0198 | 0.6982 | 0.7765 |
Loa Loa (eye worm) | serotonin transporter b | 0.0198 | 0.6982 | 0.7765 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.005 | 0.0183 | 0.0203 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.005 | 0.0183 | 0.0203 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0057 | 0.0519 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0198 | 0.6982 | 0.7765 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0072 | 0.1192 | 0.1325 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.005 | 0.0183 | 0.0183 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0241 | 0.8991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.6982 | 0.7765 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.005 | 0.0183 | 0.0203 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0072 | 0.1192 | 0.1325 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.005 | 0.0183 | 0.0203 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.005 | 0.0183 | 0.0203 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.005 | 0.0183 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1192 | 0.1325 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.005 | 0.0183 | 0.0183 |
Schistosoma mansoni | voltage-gated potassium channel | 0.005 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.6982 | 0.7765 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.005 | 0.0183 | 0.0203 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0072 | 0.1192 | 0.1325 |
Echinococcus granulosus | sodium channel protein | 0.0057 | 0.0519 | 0.0577 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0057 | 0.0519 | 0.0577 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.005 | 0.0183 | 0.0183 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0072 | 0.1192 | 0.1325 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0223 | 0.8145 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.005 | 0.0183 | 0.0183 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.005 | 0.0183 | 0.0203 |
Onchocerca volvulus | 0.0198 | 0.6982 | 1 | |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.005 | 0.0183 | 0.0203 |
Echinococcus granulosus | serotonin transporter | 0.0198 | 0.6982 | 0.7765 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.7541 | 0.8387 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0198 | 0.6982 | 0.6982 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0223 | 0.8145 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0241 | 0.8991 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.005 | 0.0183 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0183 | 0.0203 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.005 | 0.0183 | 0.0203 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0241 | 0.8991 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0198 | 0.6982 | 0.6982 |
Echinococcus multilocularis | sodium channel protein | 0.0057 | 0.0519 | 0.0577 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0198 | 0.6982 | 0.7765 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0072 | 0.1192 | 0.1192 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0198 | 0.6982 | 0.7765 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0072 | 0.1192 | 0.1192 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0241 | 0.8991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.6982 | 0.7765 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.005 | 0.0183 | 0.0203 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.005 | 0.0183 | 0.0203 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.005 | 0.0183 | 0.0183 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0198 | 0.6982 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.005 | 0.0183 | 0.0203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.