Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | caspase 6, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 3, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 7, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | caspase 6, apoptosis-related cysteine peptidase | 293 aa | 270 aa | 34.4 % |
Brugia malayi | Cell death protein 3 precursor | caspase 7, apoptosis-related cysteine peptidase | 303 aa | 256 aa | 37.1 % |
Brugia malayi | Cell death protein 3 precursor | caspase 3, apoptosis-related cysteine peptidase | 277 aa | 253 aa | 38.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.3102 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0025 | 0.0313 | 0.0313 |
Echinococcus granulosus | caspase 3 | 0.0176 | 0.6224 | 0.6224 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0087 | 0.2734 | 0.2734 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0081 | 0.251 | 0.8092 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0095 | 0.3047 | 0.3047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.3102 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0081 | 0.251 | 0.8092 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0096 | 0.3102 | 0.5 |
Echinococcus granulosus | caspase 8 | 0.0096 | 0.3102 | 0.3102 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.3102 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3102 | 1 |
Leishmania major | metacaspase, putative | 0.0096 | 0.3102 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0096 | 0.3102 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0096 | 0.3102 | 0.3102 |
Echinococcus granulosus | voltage gated potassium channel | 0.0025 | 0.0313 | 0.0313 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0025 | 0.0313 | 0.0313 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0087 | 0.2734 | 0.2734 |
Plasmodium vivax | hypothetical protein, conserved | 0.0096 | 0.3102 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0096 | 0.3102 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.3102 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0096 | 0.3102 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.3102 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0096 | 0.3102 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.0096 | 0.3102 | 0.5 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0096 | 0.3102 | 0.3102 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0096 | 0.3102 | 0.3102 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2284 | 0.7364 |
Plasmodium falciparum | metacaspase-like protein | 0.0096 | 0.3102 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0313 | 0.0313 |
Echinococcus granulosus | caspase 2 | 0.0096 | 0.3102 | 0.3102 |
Echinococcus multilocularis | caspase 2 | 0.0096 | 0.3102 | 0.3102 |
Plasmodium vivax | metacaspase 1, putative | 0.0096 | 0.3102 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3102 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.3102 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0096 | 0.3102 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0096 | 0.3102 | 0.5 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0096 | 0.3102 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0096 | 0.3102 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0096 | 0.3102 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0096 | 0.3102 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0025 | 0.0313 | 0.0313 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0313 | 0.0313 |
Trypanosoma cruzi | metacaspase, putative | 0.0096 | 0.3102 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0087 | 0.2734 | 0.8815 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0025 | 0.0313 | 0.101 |
Trypanosoma cruzi | metacaspase, putative | 0.0096 | 0.3102 | 0.5 |
Plasmodium falciparum | metacaspase 1 | 0.0096 | 0.3102 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0176 | 0.6224 | 0.6224 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0313 | 0.101 |
Trypanosoma brucei | metacaspase 5, putative | 0.0096 | 0.3102 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0096 | 0.3102 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0087 | 0.2734 | 0.8815 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0095 | 0.3047 | 0.3047 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0096 | 0.3102 | 0.5 |
Trypanosoma brucei | metacaspase | 0.0096 | 0.3102 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.8 uM | Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by microplate fluorescence assay | ChEMBL. | 21441025 |
IC50 (binding) | = 11 nM | Inhibition of human caspase 3 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | = 18 nM | Inhibition of caspase 7 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | = 6950 nM | Inhibition of caspase 6 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | > 20000 nM | Inhibition of caspase 1 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | > 50000 nM | Inhibition of caspase 8 by fluorometric assay | ChEMBL. | 21441025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.