Detailed information for compound 1511205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.373 | Formula: C19H19N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)COc1ccc2c(c1)CCCc1n2c(=O)[nH]n1
  • InChi: 1S/C19H19N3O2/c1-13-5-7-14(8-6-13)12-24-16-9-10-17-15(11-16)3-2-4-18-20-21-19(23)22(17)18/h5-11H,2-4,12H2,1H3,(H,21,23)
  • InChiKey: SXGOSRCJVRJXAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.1964 0.1964
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Brugia malayi Thioredoxin reductase 0.0046 0.0824 0.0824
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0556 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0208 0.0208
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.042 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0556 0.1992
Schistosoma mansoni hypothetical protein 0.004 0.0652 0.0652
Trypanosoma brucei cytochrome P450, putative 0.0056 0.1114 0.1114
Brugia malayi hypothetical protein 0.0128 0.3111 0.3111
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0132 0.3219 1
Echinococcus granulosus intermediate filament protein 0.0031 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0087 0.1964 0.1964
Brugia malayi glutathione reductase 0.0046 0.0824 0.0824
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0556 0.0556
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0556 0.1992
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.1114 0.1114
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1437 0.5149
Loa Loa (eye worm) cytochrome P450 family protein 0.0102 0.2378 0.2378
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0243 0.6323 0.6323
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0556 0.1992
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0525 0.0525
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1437 0.1241
Echinococcus granulosus geminin 0.0354 0.9427 0.9427
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0556 0.034
Echinococcus multilocularis musashi 0.0031 0.042 0.042
Schistosoma mansoni lamin 0.0031 0.042 0.042
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0243 0.6323 0.6323
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.1114 0.1114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0013
Brugia malayi Cytochrome P450 family protein 0.0102 0.2378 0.2378
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0556 0.1992
Schistosoma mansoni lamin 0.0031 0.042 0.042
Onchocerca volvulus 0.0055 0.1066 0.0674
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0556 0.1992
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.7065 0.6796
Mycobacterium ulcerans aminopeptidase N PepN 0.0132 0.3219 0.3064
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0556 0.034
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.7065 0.6796
Leishmania major cytochrome p450-like protein 0.0036 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0128 0.3111 0.3111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.1066 0.1066
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0556 0.1992
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0243 0.6323 0.6323
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0556 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.7065 0.6796
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.084 0.084
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0556 0.034
Onchocerca volvulus Huntingtin homolog 0.0128 0.3111 0.2809
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.084 0.063
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0224 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2792 1
Onchocerca volvulus 0.0087 0.1964 0.1612
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0126 0.3054 0.3054
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0056
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0126 0.3054 0.3054
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0101
Schistosoma mansoni aminopeptidase A (M01 family) 0.0132 0.3219 0.3219
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0126 0.3054 0.3054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1165 0.1165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0056 0.0056
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.1114 0.0911
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1437 0.1437
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.4478 0.4236
Mycobacterium leprae putative cytochrome p450 0.0036 0.0556 0.1294
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.1964 0.1964
Leishmania major cytochrome p450-like protein 0.0036 0.0556 0.0556
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.3239 0.3239
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0056
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0126 0.3054 0.3054
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.3054 0.3054
Leishmania major trypanothione reductase 0.0046 0.0824 0.0824
Brugia malayi Cytochrome P450 family protein 0.0056 0.1114 0.1114
Echinococcus multilocularis geminin 0.0354 0.9427 0.9427
Trypanosoma cruzi aminopeptidase, putative 0.0132 0.3219 0.3219
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0824 0.0824
Plasmodium vivax glutathione reductase, putative 0.0046 0.0824 0.2003
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0556 0.1992
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0652 0.0652
Loa Loa (eye worm) glutathione reductase 0.0046 0.0824 0.0824
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.004 0.0652 0.0652
Brugia malayi Cytochrome P450 family protein 0.0036 0.0556 0.0556
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0126 0.3054 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0556 0.034
Schistosoma mansoni hypothetical protein 0.0354 0.9427 0.9427
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0224 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.3054 0.3054
Brugia malayi Peptidase family M1 containing protein 0.0132 0.3219 0.3219
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0132 0.3219 0.3219
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2792 1
Entamoeba histolytica hypothetical protein 0.0024 0.0224 0.0224
Echinococcus granulosus lamin dm0 0.0031 0.042 0.042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1437 0.1437
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0132 0.3219 0.3219
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0404 0.0404
Trypanosoma brucei trypanothione reductase 0.0046 0.0824 0.0824
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0056 0.0056
Plasmodium falciparum thioredoxin reductase 0.0046 0.0824 0.2003
Onchocerca volvulus 0.0132 0.3219 0.2922
Plasmodium falciparum glutathione reductase 0.0046 0.0824 0.2003
Echinococcus multilocularis ubiquitin specific protease 41 0.0126 0.3054 0.3054
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.084 0.063
Echinococcus granulosus ubiquitin specific protease 41 0.0126 0.3054 0.3054
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2465 0.873
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0556 0.034
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.042 0.042
Schistosoma mansoni intermediate filament proteins 0.0031 0.042 0.042
Toxoplasma gondii aminopeptidase N, putative 0.0132 0.3219 1
Schistosoma mansoni hypothetical protein 0.0055 0.1066 0.1066
Brugia malayi MH2 domain containing protein 0.0133 0.3239 0.3239
Echinococcus multilocularis 0.0036 0.0556 0.0556
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.3054 0.3054
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0556 0.034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0824 0.2952
Echinococcus granulosus GPCR family 2 0.0018 0.0056 0.0056
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0132 0.3219 0.3219
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0132 0.3219 0.3219
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0224 0.0224
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0243 0.6323 0.6323
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.7065 0.6796
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0824 0.0824
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0556 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.3054 0.2417
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0525 0.0525
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.084 0.084
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.1114 0.1114
Brugia malayi hypothetical protein 0.0268 0.7013 0.7013
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2792 1
Trypanosoma brucei unspecified product 0.0039 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0132 0.3219 0.3219
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0556 0.1992
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0556 0.034
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0224 0.0802
Brugia malayi TATA binding protein associated factor 0.0132 0.3219 0.3219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1437 0.1241
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0824 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.4744 0.4262
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0066 0.0066
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0556 0.1992
Echinococcus granulosus leukotriene A 4 hydrolase 0.0132 0.3219 0.3219
Loa Loa (eye worm) hypothetical protein 0.0128 0.3111 0.3111
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.7065 0.6796
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0556 0.034
Echinococcus multilocularis lamin dm0 0.0031 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0126 0.3054 0.3054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.084 0.084
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0132 0.3219 0.3219
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0126 0.3054 0.2417
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2465 0.8832
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0556 0.0556
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.1114 0.1114
Loa Loa (eye worm) CYP4Cod1 0.0056 0.1114 0.1114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0525 0.0525
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0132 0.3219 0.3219
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0556 0.1992
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0556 0.1992
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1437 0.1437
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.084 0.084
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0556 0.034
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0224 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0632 0.0632
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0132 0.3219 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0556 0.0556
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1437 0.1437
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.3239 0.3239
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0556 0.1992
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1437 0.1241
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0132 0.3219 0.3219
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0556 0.1992
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.1964 0.1964
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0556 0.1992
Loa Loa (eye worm) peptidase family M1 containing protein 0.0132 0.3219 0.3219
Echinococcus multilocularis lamin 0.0031 0.042 0.042
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0126 0.3054 0.3054
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0556 0.034
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.4744 0.4262
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0556 0.0556
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2465 0.8832
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0556 0.1992
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0556 0.1992
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.4478 0.3972
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0208 0.0208
Leishmania major DNA polymerase kappa, putative 0.0024 0.0208 0.0208
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0824 0.2003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0208 0.0747
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0132 0.3219 0.3219
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0058 0.1165 0.1165
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0556 0.034
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.7013 0.7013
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.7065 0.7065
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0556 0.034
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.7065 0.6796
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0132 0.3219 0.3219
Echinococcus granulosus dna polymerase kappa 0.0047 0.084 0.084
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0556 0.1992
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2465 0.8832
Loa Loa (eye worm) TATA binding protein associated factor 0.0132 0.3219 0.3219
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0132 0.3219 0.3219
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Brugia malayi polk-prov protein 0.0035 0.0525 0.0525
Toxoplasma gondii aminopeptidase N protein 0.0132 0.3219 1
Loa Loa (eye worm) hypothetical protein 0.0268 0.7013 0.7013
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0824 0.0824
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0056 0.0056
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0066 0.0066
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0224 0.0224
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.7065 0.7065
Brugia malayi hypothetical protein 0.0132 0.3219 0.3219
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0556 0.1109
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0132 0.3219 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0132 0.3219 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2792 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.3111 0.2809
Loa Loa (eye worm) cytochrome P450 0.0036 0.0556 0.0556
Echinococcus granulosus lamin 0.0031 0.042 0.042
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0556 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0556 0.1992
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.084 0.084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.084 0.084
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0126 0.3054 0.3054
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.708 0.708
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0556 0.034
Brugia malayi intermediate filament protein 0.0031 0.042 0.042
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.1964 0.1964
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0126 0.3054 0.3054
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0056
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0556 0.034
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2465 0.8832
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1437 0.1437
Schistosoma mansoni hypothetical protein 0.0036 0.0556 0.0556
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2465 0.8832
Brugia malayi Cytochrome P450 family protein 0.0056 0.1114 0.1114
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0132 0.3219 0.2598
Toxoplasma gondii thioredoxin reductase 0.0046 0.0824 0.2003
Loa Loa (eye worm) hypothetical protein 0.0132 0.3219 0.3219
Echinococcus multilocularis GPCR, family 2 0.0018 0.0056 0.0056
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0126 0.3054 0.3054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1165 0.1165
Schistosoma mansoni hypothetical protein 0.0354 0.9427 0.9427
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0132 0.3219 0.3219
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0556 0.1294
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0556 0.1992
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0126 0.3054 0.2417
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.7013 0.7013
Brugia malayi cytochrome P450 0.0036 0.0556 0.0556
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0126 0.3054 0.3054
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0556 0.034
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0556 0.034
Schistosoma mansoni survival motor neuron protein 0.0055 0.1066 0.1066
Toxoplasma gondii aminopeptidase n, putative 0.0132 0.3219 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0132 0.3219 0.3219
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0066 0.0066
Echinococcus multilocularis dna polymerase kappa 0.0047 0.084 0.084
Loa Loa (eye worm) intermediate filament protein 0.0031 0.042 0.042
Schistosoma mansoni cytochrome P450 0.0036 0.0556 0.0556
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0556 0.034
Loa Loa (eye worm) hypothetical protein 0.0243 0.6323 0.6323
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0556 0.1992
Trypanosoma brucei aminopeptidase, putative 0.0132 0.3219 0.3219
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0132 0.3219 0.3219
Mycobacterium tuberculosis Probable reductase 0.0105 0.2465 0.8832
Loa Loa (eye worm) hypothetical protein 0.0243 0.6323 0.6323
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1437 0.4051
Brugia malayi follicle stimulating hormone receptor 0.027 0.708 0.708
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0556 0.034
Leishmania major cytochrome p450-like protein 0.0056 0.1114 0.1114

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 50 mg kg-1 Anticonvulsant activity in ip dosed Swiss mouse assessed as protection against maximal electroshock-induced seizures administered 30 mins before electroshock challenge measured after 30 mins ChEMBL. 21303724
TD50 (ADMET) > 931.2 mg kg-1 Neurotoxicity against Swiss mouse after 4 hrs by rotarod ataxia test ChEMBL. 21303724

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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