Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.5475 | 0.779 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0031 | 0.2236 | 0.3182 |
Schistosoma mansoni | brg-1 associated factor | 0.0034 | 0.3016 | 0.4291 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.5475 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.2236 | 0.3182 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.5475 | 0.4171 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4473 | 0.2882 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.7028 | 0.7028 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.4118 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.5475 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 0.3016 | 0.3016 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0034 | 0.3016 | 0.4291 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0046 | 0.7028 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0034 | 0.3016 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.5475 | 0.779 |
Plasmodium vivax | vivapain-2 | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.4291 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0046 | 0.7028 | 0.6172 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0034 | 0.3016 | 0.1004 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0046 | 0.7028 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.4473 | 0.4473 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0034 | 0.3016 | 0.1627 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0031 | 0.2236 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0046 | 0.7028 | 0.6172 |
Echinococcus granulosus | cathepsin l1 | 0.0031 | 0.2236 | 0.3182 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0031 | 0.2236 | 0.2236 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Brugia malayi | Inositol-1 | 0.0041 | 0.5475 | 0.5475 |
Entamoeba histolytica | cysteine protease, putative | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0034 | 0.3016 | 0.3016 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0046 | 0.7028 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.5475 | 0.6128 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0046 | 0.7028 | 0.6172 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0034 | 0.3016 | 0.4291 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.3016 | 0.4291 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.7028 | 0.6172 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0031 | 0.2236 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Leishmania major | cysteine peptidase A (CPA) | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Onchocerca volvulus | Cathepsin L homolog | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | vivapain-2 | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.1004 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.4118 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4473 | 0.6365 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0046 | 0.7028 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 0.3016 | 0.3016 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0046 | 0.7028 | 0.6172 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0034 | 0.3016 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.5475 | 0.779 |
Loa Loa (eye worm) | fibroinase | 0.0046 | 0.7028 | 0.6172 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.2236 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against 32 mA-current- for 3 secs induced seizure at 100 mg/kg, ip after 4 hrs by 6Hz psychomotor seizure test | ChEMBL. | 21306800 | |
Activity (ADMET) | Neurotoxicity in CF1 mouse assessed as minimal motor impairment at 100 mg/kg, ip after 1 min by rotarod test | ChEMBL. | 21306800 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against 32 mA-current- for 3 secs induced seizure at 100 mg/kg, ip after 0.25 hr by 6Hz psychomotor seizure test | ChEMBL. | 21306800 | |
Activity (functional) | Anticonvulsant activity in CF1 mouse assessed as protection against 32 mA-current- for 3 secs induced seizure at 100 mg/kg, ip after 2 hrs by 6Hz psychomotor seizure test | ChEMBL. | 21306800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.