Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acyl carrier protein | 0.0011 | 0.0114 | 0.0091 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.128 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.128 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.128 | 0.1336 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.0706 | 0.4068 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.128 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.128 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.387 | 0.4102 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.128 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1468 | 0.5161 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2539 | 0.268 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0239 | 0.9394 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0325 | 0.0316 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1468 | 0.5161 |
Brugia malayi | beta-lactamase | 0.004 | 0.128 | 0.1336 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2509 | 0.9866 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2509 | 0.9866 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0645 | 0.3437 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.0706 | 0.4068 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.0645 | 0.3437 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.128 | 0.128 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0017 | 0.0368 | 0.0368 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2509 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1468 | 0.1536 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.128 | 0.1336 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0325 | 0.0316 |
Onchocerca volvulus | 0.004 | 0.128 | 0.8204 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.128 | 0.4373 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.128 | 0.128 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1279 | 0.4309 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1468 | 0.5231 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.0706 | 0.0706 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2509 | 0.2648 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.128 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.128 | 0.128 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.1279 | 0.4368 |
Brugia malayi | Smad1 | 0.0016 | 0.0325 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2509 | 0.9866 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.128 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.0645 | 0.0658 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1279 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.0362 | 0.1809 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0221 | 0.0221 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.1279 | 0.4309 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.387 | 0.4102 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.387 | 0.4102 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.387 | 0.4102 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.2539 | 0.268 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0645 | 0.3437 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.0645 | 0.3437 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0994 | 0.3061 |
Brugia malayi | TAR-binding protein | 0.007 | 0.2509 | 0.2648 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0036 | 0.1131 | 0.8456 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0994 | 0.302 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.128 | 0.128 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2509 | 0.2648 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.128 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0325 | 0.0316 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0994 | 0.103 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.128 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.1279 | 0.4368 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0213 | 0.0196 |
Onchocerca volvulus | 0.004 | 0.128 | 0.8204 | |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.128 | 0.1336 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0706 | 0.4068 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.128 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2509 | 0.9866 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0645 | 0.3437 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0481 | 0.1746 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0325 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.128 | 0.1336 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.0706 | 0.4068 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2509 | 0.2648 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0994 | 0.3061 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0325 | 0.0316 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.128 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1468 | 0.5231 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.1525 | 0.1597 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.058 | 0.058 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.128 | 0.128 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0036 | 0.1131 | 0.1131 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0239 | 0.9394 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.128 | 0.1336 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.0645 | 0.0645 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0994 | 0.302 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0994 | 0.3061 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.128 | 0.1336 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.128 | 0.1336 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1279 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0994 | 0.3061 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1279 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0994 | 0.302 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.1434 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.128 | 0.1336 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0023 | 0.0615 | 0.0615 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.128 | 0.128 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.058 | 0.0589 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.0706 | 0.4878 |
Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0325 | 0.0316 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.0632 | 0.0644 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.128 | 0.4314 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.058 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.128 | 0.1336 |
Brugia malayi | RNA binding protein | 0.007 | 0.2509 | 0.2648 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0036 | 0.1131 | 0.1131 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1468 | 0.1536 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.0706 | 0.4068 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.128 | 0.1336 |
Onchocerca volvulus | 0.0042 | 0.1372 | 0.9285 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.128 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0019 | 0.0453 | 0.1454 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2509 | 0.2648 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.006 | 0.006 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0645 | 0.3437 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0481 | 0.1746 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1468 | 0.5231 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1468 | 0.5231 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0019 | 0.0453 | 0.1454 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.128 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.128 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0645 | 0.0645 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.2539 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0706 | 0.0706 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.128 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.03 | 0.1256 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.128 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.128 | 0.5 |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0481 | 0.1746 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.128 | 0.4314 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0994 | 0.103 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0023 | 0.0615 | 0.0615 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0994 | 0.103 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1468 | 0.5161 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.0706 | 0.0706 |
Brugia malayi | hypothetical protein | 0.004 | 0.1279 | 0.1335 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0481 | 0.0481 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.0645 | 0.3437 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.128 | 0.128 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1313 | 0.1371 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0019 | 0.0453 | 0.1454 |
Onchocerca volvulus | 0.004 | 0.128 | 0.8204 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.128 | 0.128 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.0645 | 0.0645 |
Brugia malayi | MH2 domain containing protein | 0.0239 | 0.9394 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.128 | 0.128 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.2509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.128 | 0.1336 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2509 | 0.9866 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.0706 | 0.4068 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0036 | 0.1131 | 0.8456 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.128 | 0.4373 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.128 | 0.128 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0994 | 0.3061 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0994 | 0.302 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0994 | 0.3061 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0994 | 0.103 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0325 | 0.0316 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0466 | 0.0466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.