TDR Targets

Basic information

Technical information

TDR Targets ID: 1512325
Name: [2-[(4-methylcyclohexyl)amino]-2-oxoethyl] 2- (naphthalene-2-carbonylamino)acetate
MW: 382.453 | Formula: C22H26N2O4
H donors: 2 H acceptors: 3 LogP: 3.78 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCC(CC1)NC(=O)COC(=O)CNC(=O)c1ccc2c(c1)cccc2
InChi: 1S/C22H26N2O4/c1-15-6-10-19(11-7-15)24-20(25)14-28-21(26)13-23-22(27)18-9-8-16-4-2-3-5-17(16)12-18/h2-5,8-9,12,15,19H,6-7,10-11,13-14H2,1H3,(H,23,27)(H,24,25)
InChiKey: OSKKFYKYWGPHBD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-[(4-methylcyclohexyl)amino]-2-oxo-ethyl] 2-(naphthalene-2-carbonylamino)acetate
2-[(2-naphthyl-oxomethyl)amino]acetic acid [2-[(4-methylcyclohexyl)amino]-2-oxoethyl] ester
2-(naphthalene-2-carbonylamino)acetic acid [2-keto-2-[(4-methylcyclohexyl)amino]ethyl] ester
[2-[(4-methylcyclohexyl)amino]-2-oxo-ethyl] 2-(naphthalen-2-ylcarbonylamino)ethanoate
T5496213
ZINC06103475

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	MATE efflux family protein, putative	0.0035	0.2574	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0317	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0317	0.009
Schistosoma mansoni	myosin xvIII	0.0022	0.0317	0.009
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0317	0.0102
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0317	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0317	0.009
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.2574	1
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0317	0.0102
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0317	0.0102
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0317	0.0357
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	AKH receptor	0.0022	0.0317	0.0357
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.1812	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0317	0.009
Brugia malayi	sulfakinin receptor protein	0.0022	0.0317	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	serotonin receptor	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Trypanosoma cruzi	membrane transporter protein, putative	0.0035	0.2574	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0317	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	amine GPCR	0.0022	0.0317	0.009
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0073	0.8881	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0317	0.0102
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0317	0.0102
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0317	0.0102
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0317	0.0357
Brugia malayi	G protein-coupled receptor	0.0022	0.0317	0.0357
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.2574	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0021	0.0228	0.0257
Schistosoma mansoni	hypothetical protein	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	opsin-like receptor	0.0022	0.0317	0.009
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0317	0.0102
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0317	0.0102
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0317	0.0102
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0317	0.009
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0317	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0317	0.0102
Brugia malayi	hypothetical protein	0.003	0.1812	0.204
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0317	0.009
Schistosoma mansoni	amine GPCR	0.0022	0.0317	0.009
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.2574	1
Onchocerca volvulus		0.0022	0.0317	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0317	0.009
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0317	0.0357
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.0032	0.2059	0.2116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.2574	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0317	0.0102
Brugia malayi	Serotonin receptor	0.0022	0.0317	0.0357
Schistosoma mansoni	amine GPCR	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0317	0.0102
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.0035	0.2574	0.2711
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0317	0.009
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0317	0.009
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0317	0.0102
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0317	0.0102
Brugia malayi	larval opioid receptor	0.0022	0.0317	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0063	0.7272	0.8141
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0317	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0317	0.009
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0317	0.009
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.8079	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0317	0.009
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0317	0.0357
Schistosoma mansoni	opsin-like receptor	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0317	0.0102
Brugia malayi	GnHR receptor homolog	0.0022	0.0317	0.0357
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0317	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0317	0.0102
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.8079	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0317	0.009
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0022	0.0317	0.5
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0317	0.009
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0317	0.0357
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	G-protein coupled receptor	0.0022	0.0317	0.0357
Echinococcus granulosus	somatostatin receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0317	0.009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0317	0.009
Echinococcus granulosus	hypothetical protein	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Onchocerca volvulus		0.0022	0.0317	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0317	0.0102
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0317	0.009
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	multidrug resistance protein	0.0035	0.2574	0.2401
Schistosoma mansoni	adenoreceptor	0.0022	0.0317	0.009
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0317	0.0357
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0317	0.0357
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.2574	1
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0317	0.0102
Brugia malayi	RE15519p	0.0022	0.0317	0.0357
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0317	0.009
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0317	0.0357
Trypanosoma brucei	membrane transporter protein, putative	0.0035	0.2574	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.1812	0.183
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0317	0.0102
Brugia malayi	Dopamine receptor	0.0022	0.0317	0.0357
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0317	0.0102
Brugia malayi	neuropeptide F receptor	0.0022	0.0317	0.0357
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0317	0.0102
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0317	0.0102
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0073	0.8881	1
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0317	0.0102
Schistosoma mansoni	opsin-like receptor	0.0022	0.0317	0.009
Leishmania major	hypothetical protein, conserved	0.0035	0.2574	1
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0317	0.0102
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0317	0.0102
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0317	0.0357
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0073	0.8881	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0317	0.0102
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	hypothetical protein	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.0035	0.2574	0.2711
Trypanosoma brucei	membrane transporter protein, putative	0.0035	0.2574	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Onchocerca volvulus		0.0022	0.0317	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	serotonin receptor	0.0022	0.0317	0.0102
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.1812	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	hypothetical protein	0.0022	0.0317	0.009
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0317	0.0102
Brugia malayi	G-protein coupled receptor	0.0022	0.0317	0.0357
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0317	0.0102
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0073	0.8881	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0317	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Schistosoma mansoni	hypothetical protein	0.0022	0.0317	0.009
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0317	0.0102
Brugia malayi	putative neuropeptide receptor	0.0022	0.0317	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0317	0.0357
Echinococcus granulosus	sex peptide receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0317	0.009
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Trypanosoma brucei	membrane transporter protein, putative	0.0035	0.2574	1
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Brugia malayi	neuropeptide F receptor	0.0022	0.0317	0.0357
Onchocerca volvulus		0.0022	0.0317	0.5
Schistosoma mansoni	amine GPCR	0.0022	0.0317	0.009
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0317	0.009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5
Leishmania major	hypothetical protein, conserved	0.0035	0.2574	1
Echinococcus multilocularis	serotonin receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0317	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0317	0.0102
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.1812	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0317	0.009
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.1812	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0317	0.0102
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0317	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0022	0.0317	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0317	0.0102
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0317	0.0102
Schistosoma mansoni	amine GPCR	0.0022	0.0317	0.009
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0317	0.0102
Brugia malayi	Serotonin receptor	0.0022	0.0317	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0317	0.0102
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0317	0.0102
Brugia malayi	hypothetical protein	0.0022	0.0317	0.0357
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0317	0.0357
Onchocerca volvulus		0.0022	0.0317	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0317	0.0102
Onchocerca volvulus		0.0022	0.0317	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.9341 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1736233

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1512325