Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0541 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0672 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.0276 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.0276 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0541 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.0276 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.0105 | 0.0354 | 0.5 |
Mycobacterium ulcerans | recombinase A | 0.0105 | 0.0354 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0616 | 0.339 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0672 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Chlamydia trachomatis | recombinase RecA | 0.0105 | 0.0354 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.0672 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.0672 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Treponema pallidum | recombinase A | 0.0105 | 0.0354 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.0672 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0276 | 0.5037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 2.7 uM | Cytotoxicity against human KB cells after 48 hrs by sulforhodamine B based ELISA | ChEMBL. | 21402478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.