Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-akt murine thymoma viral oncogene homolog 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.004 | 0.0089 | 0.0445 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0028 | 0.0015 | 0.0187 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0392 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Treponema pallidum | recombinase A | 0.0104 | 0.0467 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.0781 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.0089 | 0.2277 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0119 | 0.1859 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0038 | 0.0075 | 0.0243 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0652 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.0392 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0028 | 0.0015 | 0.0187 |
Trypanosoma cruzi | Protein kinase B | 0.0028 | 0.0015 | 0.0374 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0392 | 0.592 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0028 | 0.0015 | 0.0374 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.004 | 0.0089 | 0.1394 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0075 | 0.1904 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0057 | 0.0729 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.0392 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0057 | 0.1454 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0612 | 0.3468 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0652 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.0392 | 1 |
Mycobacterium ulcerans | recombinase A | 0.0104 | 0.0467 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.0392 | 0.5014 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0057 | 0.1454 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0781 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0038 | 0.0075 | 0.0243 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0057 | 0.0729 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0057 | 0.1454 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.0392 | 0.5014 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.0781 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0057 | 0.0477 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.0392 | 0.4622 |
Toxoplasma gondii | AGC kinase | 0.0038 | 0.0075 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0028 | 0.0015 | 0.0374 |
Schistosoma mansoni | kinase | 0.0047 | 0.0126 | 0.1754 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.0392 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.0392 | 0.4622 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0781 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.0089 | 0.2277 |
Chlamydia trachomatis | recombinase RecA | 0.0104 | 0.0467 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0119 | 0.1859 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.004 | 0.0089 | 0.0445 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0392 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0057 | 0.0665 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0032 | 0.004 | 0.1026 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0028 | 0.0015 | 0.0374 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.0392 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0392 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.0104 | 0.0467 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.0781 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0089 | 0.0963 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0032 | 0.004 | 0.1026 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0057 | 0.1454 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.3 uM | Inhibition of AKT1 by IMAP assay | ChEMBL. | 21392984 |
IC50 (binding) | = 18.6 uM | Inhibition of AKT1 in human LNCaP cells assessed as PRAS40 phosphorylation at Thr246 after 1.5 hrs | ChEMBL. | 21392984 |
Inhibition (binding) | Inhibition of AKT2 by IMAP assay | ChEMBL. | 21392984 | |
Inhibition (binding) | Inhibition of AKT3 by IMAP assay | ChEMBL. | 21392984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.