Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0023 | 0.1607 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.5044 | 0.5044 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0014 | 0.0105 | 0.0105 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.5044 | 0.5044 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.5044 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.4576 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.5696 | 0.5696 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0014 | 0.0105 | 0.0105 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0032 | 0.3037 | 0.3037 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0014 | 0.0105 | 0.0105 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0023 | 0.1607 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0023 | 0.1607 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0014 | 0.0105 | 0.0105 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0014 | 0.0105 | 0.0105 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0014 | 0.0105 | 0.0105 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.5044 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0023 | 0.1607 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4106 | 0.8141 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0014 | 0.0105 | 0.0105 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0032 | 0.3037 | 0.3037 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.5696 | 0.5696 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.4576 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0014 | 0.0105 | 0.0105 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0014 | 0.0105 | 0.0105 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0023 | 0.1607 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0032 | 0.3037 | 0.3037 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0014 | 0.0105 | 0.0105 |
Echinococcus granulosus | glutamate receptor 2 | 0.0014 | 0.0105 | 0.0105 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0023 | 0.1607 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at NR2A transfected in oocytes upto 90 uM | ChEMBL. | 21524576 | |
IC50 (binding) | = 2.15 uM | Inhibition of human ERG expressed in CHOK1 cells electrophysiology study | ChEMBL. | 21524576 |
Ki (binding) | = 48 nM | Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membrane | ChEMBL. | 21524576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.