Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0029 | 0.0484 | 0.0484 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.003 | 0.0562 | 0.0562 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.003 | 0.0562 | 0.0562 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.009 | 0.7348 | 0.7348 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.2432 | 0.2757 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.3996 | 0.5061 |
Plasmodium vivax | vivapain-1 | 0.0046 | 0.2432 | 0.2757 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Loa Loa (eye worm) | cysteine protease | 0.009 | 0.7348 | 0.7348 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0032 | 0.0838 | 0.1141 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.006 | 0.3996 | 0.3996 |
Echinococcus granulosus | cathepsin l1 | 0.006 | 0.3996 | 0.5439 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.3996 | 0.3182 |
Brugia malayi | cathepsin L-like precursor | 0.006 | 0.3996 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3996 | 0.3996 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0562 | 0.0562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0562 | 0.0562 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.003 | 0.0562 | 0.0562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.7348 | 0.7348 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.3996 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3996 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3996 | 0.3996 |
Echinococcus granulosus | cathepsin L | 0.0046 | 0.2432 | 0.3311 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Echinococcus granulosus | cysteine protease | 0.0046 | 0.2432 | 0.3311 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.3996 | 0.3996 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0029 | 0.0484 | 0.0658 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0032 | 0.0838 | 0.1141 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2432 | 0.2432 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.009 | 0.7348 | 0.7348 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.3996 | 0.3996 |
Brugia malayi | Papain family cysteine protease containing protein | 0.009 | 0.7348 | 0.7348 |
Loa Loa (eye worm) | ctsf protein | 0.009 | 0.7348 | 0.7348 |
Echinococcus granulosus | glutamate receptor 2 | 0.0029 | 0.0484 | 0.0658 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.009 | 0.7348 | 1 |
Plasmodium vivax | vivapain-2 | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2432 | 0.2432 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0029 | 0.0484 | 0.0658 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.006 | 0.3996 | 0.3996 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.009 | 0.7348 | 0.5 |
Trypanosoma cruzi | cysteine protease, putative | 0.0046 | 0.2432 | 0.2757 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.009 | 0.7348 | 0.7348 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.009 | 0.7348 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.009 | 0.7348 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0562 | 0.0562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.009 | 0.7348 | 0.7348 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Loa Loa (eye worm) | fibroinase | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cysteine protease | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.7348 | 0.7348 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0029 | 0.0484 | 0.0658 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0046 | 0.2432 | 0.3311 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.2432 | 0.2432 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0046 | 0.2432 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0046 | 0.2432 | 0.2757 |
Onchocerca volvulus | Cathepsin L homolog | 0.009 | 0.7348 | 0.7348 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0046 | 0.2432 | 0.2757 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.7348 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Plasmodium vivax | unspecified product | 0.0046 | 0.2432 | 0.2757 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.006 | 0.3996 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Schistosoma mansoni | cathepsin s | 0.003 | 0.0562 | 0.0562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cysteine protease | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0046 | 0.2432 | 0.3311 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.0089 | 0.7211 | 0.7211 | |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.0562 | 0.0562 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0032 | 0.0838 | 0.1141 |
Plasmodium vivax | vivapain-3 | 0.0046 | 0.2432 | 0.2757 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.006 | 0.3996 | 0.3996 | |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Plasmodium vivax | vivapain-2 | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 100 uM | Ex vivo immunosuppressive activity in Drosophila larvae assessed as inhibition of IMD signaling pathway by beta-galactosidase reporter gene assay | ChEMBL. | 21334120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.