Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cysteine protease | 0.009 | 0.7348 | 0.7348 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0046 | 0.2432 | 0.2757 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Leishmania major | cysteine peptidase A (CPA) | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Schistosoma mansoni | cathepsin s | 0.003 | 0.0562 | 0.0562 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7348 | 0.7348 |
Echinococcus multilocularis | cysteine protease | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Plasmodium vivax | vivapain-3 | 0.0046 | 0.2432 | 0.2757 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.006 | 0.3996 | 0.3996 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0046 | 0.2432 | 0.2757 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.3996 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.006 | 0.3996 | 0.3182 |
Entamoeba histolytica | cysteine protease, putative | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.7348 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.003 | 0.0562 | 0.0562 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2432 | 0.2432 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0032 | 0.0838 | 0.1141 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.7348 | 0.7348 |
Onchocerca volvulus | 0.0089 | 0.7211 | 0.7211 | |
Echinococcus granulosus | cathepsin l1 | 0.006 | 0.3996 | 0.5439 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0562 | 0.0562 |
Onchocerca volvulus | Cathepsin F homolog | 0.009 | 0.7348 | 0.7348 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Plasmodium vivax | vivapain-2 | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | fibroinase | 0.009 | 0.7348 | 0.7348 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.7348 | 0.7348 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3996 | 0.3996 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.003 | 0.0562 | 0.0562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0029 | 0.0484 | 0.0658 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.3996 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.006 | 0.3996 | 0.3996 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.009 | 0.7348 | 0.7348 |
Onchocerca volvulus | Cathepsin L homolog | 0.009 | 0.7348 | 0.7348 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.3996 | 0.3996 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0046 | 0.2432 | 0.2757 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0029 | 0.0484 | 0.0484 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.009 | 0.7348 | 1 |
Plasmodium vivax | unspecified product | 0.0046 | 0.2432 | 0.2757 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0046 | 0.2432 | 0.3311 |
Echinococcus granulosus | cysteine protease | 0.0046 | 0.2432 | 0.3311 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0562 | 0.0562 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.3996 | 0.3996 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.0562 | 0.0562 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2432 | 0.2432 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cysteine protease | 0.009 | 0.7348 | 1 |
Plasmodium vivax | vivapain-2 | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.009 | 0.7348 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3996 | 0.3996 |
Onchocerca volvulus | 0.006 | 0.3996 | 0.3996 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0029 | 0.0484 | 0.0658 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0032 | 0.0838 | 0.1141 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.006 | 0.3996 | 0.3996 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.003 | 0.0562 | 0.0562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Echinococcus granulosus | cathepsin L | 0.0046 | 0.2432 | 0.3311 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3996 | 0.3996 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.3996 | 0.5061 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.009 | 0.7348 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7348 | 0.7348 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0029 | 0.0484 | 0.0658 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0484 | 0.0658 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0046 | 0.2432 | 0.2757 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0029 | 0.0484 | 0.0658 |
Loa Loa (eye worm) | ctsf protein | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7348 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.2432 | 0.2432 |
Onchocerca volvulus | 0.009 | 0.7348 | 0.7348 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.009 | 0.7348 | 0.5 |
Plasmodium vivax | vivapain-1 | 0.0046 | 0.2432 | 0.2757 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.009 | 0.7348 | 0.7348 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0032 | 0.0838 | 0.1141 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.009 | 0.7348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0562 | 0.0562 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.009 | 0.7348 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.2432 | 0.2757 |
Onchocerca volvulus | Cathepsin L homolog | 0.009 | 0.7348 | 0.7348 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7348 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0046 | 0.2432 | 0.3311 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 100 uM | Ex vivo immunosuppressive activity in Drosophila larvae assessed as inhibition of IMD signaling pathway by beta-galactosidase reporter gene assay | ChEMBL. | 21334120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.