Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.1897 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.4312 | 0.4312 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.1897 | 0.1551 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.1897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.041 | 0.041 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.1897 | 1 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.1897 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.1897 | 0.1897 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.4312 | 0.4069 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.041 | 0.479 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0554 | 0.0969 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0554 | 0.6473 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0554 | 0.0969 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.4312 | 0.4312 |
Onchocerca volvulus | 0.0047 | 0.0856 | 1 | |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0856 | 0.0465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.