TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.956 | Formula: C24H28ClFN4O2
H donors: 1 H acceptors: 3 LogP: 4.82 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cnc(nc1)N1CCC(CC1)CC1CC1COc1ccc(c(c1)F)C(=O)NC1CC1
InChi: 1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
InChiKey: HGXIXRDSWVTXLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	G protein-coupled receptor 119	Starlite/ChEMBL	References
Mus musculus	G-protein coupled receptor 119	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	G protein-coupled receptor 119	335 aa	274 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0016	0.1388	0.1557
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.2027	0.2273
Brugia malayi	larval opioid receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0016	0.1388	0.1557
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Schistosoma mansoni	histamine h1 receptor	0.0018	0.2027	0.2027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Echinococcus granulosus	tyrosine kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	neuropeptide receptor	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0016	0.1388	0.1557
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	biogenic amine receptor	0.0018	0.2027	0.2027
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Onchocerca volvulus		0.0018	0.2027	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	biogenic amine receptor	0.0018	0.2027	0.2027
Brugia malayi	follicle stimulating hormone receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.8918	1
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.2027	0.2273
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.2027	0.2027
Brugia malayi	G-protein coupled receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	tyrosine kinase	0.0016	0.1388	0.1388
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0016	0.1388	0.6848
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.2027	0.2273
Brugia malayi	GnHR receptor homolog	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0016	0.1388	0.1557
Echinococcus multilocularis	serotonin receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0016	0.1388	0.1557
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0016	0.1388	0.6848
Loa Loa (eye worm)	hypothetical protein	0.0013	0.055	0.0616
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.2027	0.2273
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.055	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	protein-tyrosine kinase	0.0016	0.1388	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine kinase	0.0016	0.1388	0.1557
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.2027	0.2273
Echinococcus multilocularis	c src tyrosine kinase	0.0016	0.1388	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.2027	0.2027
Onchocerca volvulus		0.0018	0.2027	1
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.2027	0.2273
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.2027	0.2273
Brugia malayi	Dopamine receptor protein 1	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0016	0.1388	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	neuropeptide F receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.8918	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus multilocularis	neuropeptide s receptor	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.2027	0.2273
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.2027	0.2273
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.2027	0.2273
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.8143	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Brugia malayi	neuropeptide F receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.2027	0.2273
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Brugia malayi	Dopamine receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	tyrosine kinase	0.0016	0.1388	0.1388
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	TK/ABL protein kinase	0.0016	0.1388	0.1557
Brugia malayi	AKH receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	hypothetical protein	0.0018	0.2027	0.2027
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.2027	0.2027
Brugia malayi	Serotonin receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0016	0.1388	0.1557
Echinococcus granulosus	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	putative neuropeptide receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0016	0.1388	0.1557
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.2027	0.2027
Schistosoma mansoni	adenoreceptor	0.0018	0.2027	0.2027
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase Blk	0.0016	0.1388	0.1557
Echinococcus multilocularis	sex peptide receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	serotonin receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.2027	0.2027
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.2027	0.2273
Brugia malayi	sulfakinin receptor protein	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.2027	0.2027
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0016	0.1388	0.1557
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.2027	0.2273
Echinococcus multilocularis	somatostatin receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0016	0.1388	0.1557
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus granulosus	g protein coupled receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	amine GPCR	0.0018	0.2027	0.2027
Echinococcus multilocularis	serotonin receptor	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.8918	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.2027	0.2027
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.2027	0.2273
Brugia malayi	Protein kinase domain containing protein	0.0016	0.1388	0.1557
Brugia malayi	Protein kinase domain containing protein	0.0016	0.1388	0.1557
Loa Loa (eye worm)	SRC-1	0.0016	0.1388	0.1557
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0016	0.1388	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0016	0.1388	0.6848
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.055	0.0616
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.2027	0.2027
Schistosoma mansoni	opsin-like receptor	0.0018	0.2027	0.2027
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.055	0.0616
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	sex peptide receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	biogenic amine receptor	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.2027	0.2027
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.2027	0.2273
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.2027	0.2273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0039	0.7362	0.8255
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	orexin receptor type 2	0.0018	0.2027	0.2273
Brugia malayi	Melatonin receptor type 1A	0.0018	0.2027	0.2273
Schistosoma mansoni	amine GPCR	0.0018	0.2027	0.2027
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0016	0.1388	0.1388
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0016	0.1388	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.2027	0.2273
Brugia malayi	ORL1-like opioid receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.2027	0.2027
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.2027	0.2273
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.2027	0.2027
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0016	0.1388	0.6848
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	myosin xvIII	0.0018	0.2027	0.2027
Brugia malayi	G-protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	neuropeptide receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase shark	0.0016	0.1388	0.1557
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Echinococcus granulosus	c src tyrosine kinase	0.0016	0.1388	0.1557
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	g protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.055	0.0616
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	SH2 domain containing protein	0.0016	0.1388	0.1557
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.2027	0.2273
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0016	0.1388	0.1557
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0018	0.2027	1
Schistosoma mansoni	tyrosine kinase	0.0016	0.1388	0.1388
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.2027	0.2273
Schistosoma mansoni	tyrosine kinase	0.0016	0.1388	0.1388
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.2027	0.2273
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.2027	0.2273
Echinococcus granulosus	neuropeptide receptor A26	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.2027	0.2027
Brugia malayi	Protein kinase domain containing protein	0.0016	0.1388	0.1557
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.055	0.055
Schistosoma mansoni	opsin-like receptor	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.8143	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.2027	0.2027
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.2027	0.2273
Echinococcus multilocularis	neuropeptide receptor A26	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.2027	0.2273
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0016	0.1388	0.1557
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0016	0.1388	0.1557
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.2027	0.2273
Brugia malayi	G protein-coupled receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Echinococcus granulosus	somatostatin receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Schistosoma mansoni	tyrosine kinase	0.0016	0.1388	0.1388
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.2027	0.2027
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.2027	0.2273
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0016	0.1388	0.1557
Onchocerca volvulus		0.0018	0.2027	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.2027	0.2273
Schistosoma mansoni	hypothetical protein	0.0018	0.2027	0.2027
Schistosoma mansoni	amine GPCR	0.0018	0.2027	0.2027
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	Tyrosine-protein kinase abl-1	0.0016	0.1388	0.1557
Schistosoma mansoni	neuropeptide receptor	0.0018	0.2027	0.2027
Echinococcus multilocularis	tyrosine protein kinase shark	0.0016	0.1388	0.1557
Schistosoma mansoni	neuropeptide receptor	0.0018	0.2027	0.2027
Schistosoma mansoni	hypothetical protein	0.0018	0.2027	0.2027
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.055	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Brugia malayi	Dopamine receptor protein 2	0.0018	0.2027	0.2273
Brugia malayi	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	opsin-like receptor	0.0018	0.2027	0.2027
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.1388	0.1557
Echinococcus granulosus	neuropeptide s receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	hypothetical protein	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0016	0.1388	0.1557
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.2027	0.2273
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0018	0.2027	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase Srms	0.0016	0.1388	0.1557
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.2027	0.2273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0018	0.2027	1
Schistosoma mansoni	neuropeptide receptor	0.0018	0.2027	0.2027
Echinococcus granulosus	fmrfamide receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.2027	0.2273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Echinococcus granulosus	allatostatin A receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.2027	0.2273
Onchocerca volvulus		0.0016	0.1388	0.6848
Onchocerca volvulus		0.0016	0.1388	0.6848
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0016	0.1388	0.1557
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.055	0.055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.2027	0.2027
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.2027	0.2027
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Brugia malayi	Serotonin receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0016	0.1388	0.1557
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.2027	0.2273
Brugia malayi	Protein kinase domain containing protein	0.0016	0.1388	0.1557
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0016	0.1388	0.1557
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	TK protein kinase	0.0016	0.1388	0.1557
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.2027	0.2027
Brugia malayi	SRC-1	0.0016	0.1388	0.1557
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0016	0.1388	0.1557
Onchocerca volvulus		0.0018	0.2027	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.2027	0.2027
Onchocerca volvulus		0.0018	0.2027	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0016	0.1388	0.1557
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0016	0.1388	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273
Schistosoma mansoni	tyrosine kinase	0.0016	0.1388	0.1388
Brugia malayi	Protein kinase domain containing protein	0.0016	0.1388	0.1557
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.1388	0.1557
Echinococcus granulosus	g protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.2027	0.2273
Echinococcus granulosus	neuropeptide receptor	0.0018	0.2027	0.2273
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.8918	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.2027	0.2273
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.2027	0.2273
Brugia malayi	RE15519p	0.0018	0.2027	0.2273
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.2027	0.2027
Schistosoma mansoni	amine GPCR	0.0018	0.2027	0.2027
Brugia malayi	SH2 domain containing protein	0.0016	0.1388	0.1557
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.2027	0.2273
Schistosoma mansoni	amine GPCR	0.0018	0.2027	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2027	0.2273

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 9 nM	Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay	ChEMBL.	21273063
EC50 (functional)	= 18 nM	Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay	ChEMBL.	21273063
EC50 (functional)	= 18 nM	Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay	ChEMBL.	21273063
EC50 (functional)	= 36 nM	Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay	ChEMBL.	21273063
IC50 (binding)	= 1200 nM	Inhibition of human ERG	ChEMBL.	21273063
IC50 (binding)	> 30000 nM	Inhibition of human ERG	ChEMBL.	21273063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1771099

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1513474