Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0059 | 0.2067 | 0.2067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0088 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0088 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0088 | 0.6495 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0059 | 0.2067 | 0.2067 |
Onchocerca volvulus | Cathepsin F homolog | 0.0088 | 0.6495 | 0.5582 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.2067 | 0.2067 |
Entamoeba histolytica | cysteine protease, putative | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0059 | 0.2067 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.2067 | 0.2067 |
Loa Loa (eye worm) | fibroinase | 0.0088 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0059 | 0.2067 | 0.2067 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | 0.0087 | 0.6314 | 0.5354 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0059 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0088 | 0.6495 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0059 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0088 | 0.6495 | 0.5582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0088 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0088 | 0.6495 | 0.6495 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0088 | 0.6495 | 0.6495 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0059 | 0.2067 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0088 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0059 | 0.2067 | 0.3182 |
Loa Loa (eye worm) | cysteine protease | 0.0088 | 0.6495 | 0.5582 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0088 | 0.6495 | 0.5582 |
Onchocerca volvulus | Cathepsin L homolog | 0.0088 | 0.6495 | 0.5582 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.6495 | 0.5582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0088 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0088 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 76 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 100 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Activity (ADMET) | = 101 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 10 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Activity (ADMET) | = 103 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 50 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Activity (ADMET) | = 118 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 20 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.