TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 808.834 | Formula: C38H48N8O12
H donors: 6 H acceptors: 10 LogP: 3.56 Rotable bonds: 26
Rule of 5 violations (Lipinski): 3
SMILES: COc1cc(CNc2nc(NCC(OC(=O)CCC(=O)O)C)nc3c2nc(NCC(OC(=O)CCC(=O)O)C)nc3NCc2ccc(c(c2)OC)OC)ccc1OC
InChi: 1S/C38H48N8O12/c1-21(57-31(51)13-11-29(47)48)17-41-37-43-33-34(35(45-37)39-19-23-7-9-25(53-3)27(15-23)55-5)44-38(42-18-22(2)58-32(52)14-12-30(49)50)46-36(33)40-20-24-8-10-26(54-4)28(16-24)56-6/h7-10,15-16,21-22H,11-14,17-20H2,1-6H3,(H,47,48)(H,49,50)(H2,39,41,43,45)(H2,40,42,44,46)
InChiKey: YZTTWYCIVAHJGQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tubulin gamma 1 chain	0.0181	0.3287	0.3583
Echinococcus granulosus	tubulin alpha chain	0.0236	0.4725	0.551
Trypanosoma cruzi	tubulin gamma chain	0.0181	0.3287	0.3583
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0236	0.4725	0.551
Trypanosoma brucei	epsilon tubulin	0.0181	0.3287	0.3583
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0157	0.2674	0.3311
Leishmania major	beta tubulin	0.0364	0.8075	1
Schistosoma mansoni	tubulin subunit beta	0.0364	0.8075	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0364	0.8075	1
Plasmodium falciparum	tubulin beta chain	0.0364	0.8075	1
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Schistosoma mansoni	alpha tubulin	0.0236	0.4725	0.551
Loa Loa (eye worm)	tubulin beta-1 chain	0.0364	0.8075	1
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Schistosoma mansoni	tubulin subunit beta	0.0364	0.8075	1
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Echinococcus granulosus	alpha tubulin	0.0236	0.4725	0.551
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Giardia lamblia	Beta tubulin	0.0364	0.8075	1
Leishmania major	beta tubulin	0.0364	0.8075	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0236	0.4725	0.551
Echinococcus granulosus	tubulin alpha chain	0.0236	0.4725	0.551
Schistosoma mansoni	tubulin subunit alpha	0.0236	0.4725	0.551
Echinococcus multilocularis	tubulin beta 1 chain	0.0364	0.8075	1
Loa Loa (eye worm)	BEN-1 protein	0.0364	0.8075	1
Leishmania major	biotin/lipoate protein ligase-like protein	0.0205	0.3921	0.4433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.363	0.4043
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0194	0.363	0.4043
Trypanosoma cruzi	Biotin--acetyl-CoA-carboxylase ligase, putative	0.0205	0.3921	0.4433
Echinococcus multilocularis	beta tubulin	0.0364	0.8075	1
Chlamydia trachomatis	hypothetical protein	0.0186	0.3425	0.0103
Leishmania major	beta tubulin	0.0364	0.8075	1
Loa Loa (eye worm)	BEN-1 protein	0.0364	0.8075	1
Giardia lamblia	Hypothetical protein	0.0205	0.3921	0.4433
Toxoplasma gondii	alpha tubulin TUBA1	0.0236	0.4725	0.551
Trypanosoma brucei	alpha tubulin	0.0236	0.4725	0.551
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0195	0.3664	0.4089
Leishmania major	beta tubulin	0.0364	0.8075	1
Trichomonas vaginalis	tubulin, putative	0.0102	0.1235	0.0833
Schistosoma mansoni	biotin-protein ligase	0.0205	0.3921	0.4433
Echinococcus multilocularis	tubulin alpha 3 chain	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0236	0.4725	0.551
Echinococcus granulosus	Tubulin beta 2C chain	0.0364	0.8075	1
Giardia lamblia	Beta tubulin	0.0364	0.8075	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0364	0.8075	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0157	0.2674	0.2761
Chlamydia trachomatis	biotin synthetase	0.0205	0.3921	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0236	0.4725	0.551
Leishmania major	beta tubulin	0.0364	0.8075	1
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Trichomonas vaginalis	tubulin alpha chain, putative	0.0364	0.8075	1
Trypanosoma brucei	alpha tubulin	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin alpha chain, putative	0.0181	0.3287	0.3583
Toxoplasma gondii	beta-tubulin, putative	0.0364	0.8075	1
Trypanosoma brucei	epsilon tubulin	0.0181	0.3287	0.3583
Echinococcus granulosus	Tubulin beta 2C chain	0.0364	0.8075	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0364	0.8075	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0186	0.3419	0.9982
Entamoeba histolytica	tubulin alpha-1 chain	0.0236	0.4725	0.3004
Trichomonas vaginalis	tubulin alpha chain, putative	0.0102	0.1235	0.0833
Loa Loa (eye worm)	tubulin gamma chain	0.0181	0.3287	0.407
Loa Loa (eye worm)	tubulin beta-2A chain	0.0364	0.8075	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0364	0.8075	1
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Brugia malayi	Tubulin alpha chain	0.0236	0.4725	0.551
Echinococcus granulosus	5'partial\|biotin protein ligase	0.0186	0.3425	0.3767
Plasmodium falciparum	alpha tubulin 2	0.0236	0.4725	0.551
Loa Loa (eye worm)	beta-tubulin	0.0364	0.8075	1
Entamoeba histolytica	biotin--acetyl-CoA-carboxylase ligase, putative	0.0205	0.3921	0.1325
Echinococcus multilocularis	tubulin alpha chain	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin beta chain, putative	0.0236	0.4725	0.551
Echinococcus multilocularis	tubulin alpha chain	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0364	0.8075	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0186	0.3419	0.3761
Brugia malayi	biotin--acetyl-CoA-carboxylase ligase family protein	0.0205	0.3921	0.4433
Plasmodium falciparum	alpha tubulin 1	0.0236	0.4725	0.551
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Brugia malayi	beta-tubulin, identical	0.0364	0.8075	1
Toxoplasma gondii	beta tubulin	0.0364	0.8075	1
Schistosoma mansoni	tubulin subunit alpha	0.0236	0.4725	0.551
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Loa Loa (eye worm)	hypothetical protein	0.0186	0.3425	0.4241
Trichomonas vaginalis	tubulin, putative	0.0364	0.8075	1
Brugia malayi	tubulin alpha chain - mouse	0.0236	0.4725	0.551
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0181	0.3287	0.3583
Trichomonas vaginalis	tubulin beta chain, putative	0.0236	0.4725	0.551
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0133	0.2052	0.2541
Echinococcus multilocularis	tubulin alpha	0.0181	0.3287	0.3583
Loa Loa (eye worm)	tubulin alpha chain	0.0236	0.4725	0.5851
Trichomonas vaginalis	tubulin, putative	0.0102	0.1235	0.0833
Brugia malayi	Tubulin alpha-2 chain	0.0236	0.4725	0.551
Echinococcus granulosus	tubulin alpha 3 chain	0.0236	0.4725	0.551
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin beta chain, putative	0.0236	0.4725	0.551
Trypanosoma brucei	beta tubulin	0.0364	0.8075	1
Leishmania major	epsilon tubulin, putative	0.0181	0.3287	0.3583
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0186	0.3419	0.3761
Entamoeba histolytica	tubulin family protein	0.0364	0.8075	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0102	0.1235	0.0833
Trichomonas vaginalis	tubulin gamma chain, putative	0.0181	0.3287	0.3583
Leishmania major	beta tubulin	0.0364	0.8075	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2052	0.2541
Mycobacterium ulcerans	bifunctional protein BirA	0.0418	0.9503	1
Onchocerca volvulus		0.0102	0.1235	0.5
Schistosoma mansoni	biotin-protein ligase	0.0186	0.3425	0.3767
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Loa Loa (eye worm)	alpha-tubulin	0.0236	0.4725	0.5851
Mycobacterium tuberculosis	Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas	0.0186	0.3425	0.2995
Plasmodium vivax	tubulin beta chain, putative	0.0364	0.8075	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0236	0.4725	0.551
Loa Loa (eye worm)	tubulin alpha 2	0.0157	0.2674	0.3311
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0194	0.363	0.4495
Trypanosoma cruzi	epsilon tubulin, putative	0.0181	0.3287	0.3583
Leishmania major	beta tubulin	0.0364	0.8075	1
Giardia lamblia	Alpha-tubulin	0.0236	0.4725	0.551
Schistosoma mansoni	tubulin subunit beta	0.0364	0.8075	1
Plasmodium vivax	biotin--[acetyl-CoA-carboxylase] synthetase, putative	0.0205	0.3921	0.4433
Loa Loa (eye worm)	alpha-tubulin	0.0236	0.4725	0.5851
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0236	0.4725	0.5851
Echinococcus multilocularis	biotin protein ligase	0.0205	0.3921	0.4433
Echinococcus granulosus	tubulin alpha chain	0.0236	0.4725	0.551
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Mycobacterium tuberculosis	Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO)	0.0161	0.278	0.2309
Trichomonas vaginalis	tubulin beta chain, putative	0.0236	0.4725	0.551
Leishmania major	beta tubulin	0.0364	0.8075	1
Leishmania major	beta tubulin	0.0364	0.8075	1
Leishmania major	gamma-tubulin	0.0181	0.3287	0.3583
Echinococcus multilocularis	Tubulin beta 2C chain	0.0364	0.8075	1
Brugia malayi	alpha-tubulin	0.0236	0.4725	0.551
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Trypanosoma cruzi	alpha tubulin, putative	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0102	0.1235	0.0833
Trichomonas vaginalis	tubulin gamma chain, putative	0.0364	0.8075	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0364	0.8075	1
Echinococcus granulosus	protoporphyrinogen oxidase	0.0161	0.278	0.2904
Plasmodium falciparum	biotin--acetyl-CoA-carboxylase, putative	0.0205	0.3921	0.4433
Plasmodium falciparum	tubulin epsilon chain, putative	0.0181	0.3287	0.3583
Echinococcus granulosus	tubulin gamma 1 chain	0.0181	0.3287	0.3583
Trypanosoma brucei	beta tubulin	0.0364	0.8075	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0236	0.4725	0.551
Schistosoma mansoni	alpha tubulin	0.0236	0.4725	0.551
Leishmania major	beta tubulin	0.0364	0.8075	1
Plasmodium vivax	tubulin gamma chain, putative	0.0181	0.3287	0.3583
Echinococcus multilocularis	tubulin epsilon chain	0.0181	0.3287	0.3583
Echinococcus granulosus	tubulin alpha 3 chain	0.0236	0.4725	0.551
Leishmania major	beta tubulin	0.0364	0.8075	1
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Brugia malayi	Tubulin alpha-2 chain	0.0236	0.4725	0.551
Brugia malayi	Tubulin beta chain	0.0102	0.1235	0.0833
Trichomonas vaginalis	tubulin beta chain, putative	0.0236	0.4725	0.551
Entamoeba histolytica	tubulin family protein	0.0364	0.8075	1
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Echinococcus granulosus	peroxisome assembly protein 26	0.0236	0.4725	0.551
Echinococcus granulosus	tubulin beta 4A class IVa	0.0364	0.8075	1
Brugia malayi	Tubulin beta-1 chain	0.0364	0.8075	1
Echinococcus multilocularis	N terminal of biotin protein ligase	0.0186	0.3425	0.3767
Leishmania major	beta tubulin	0.0364	0.8075	1
Trypanosoma brucei	epsilon tubulin	0.0181	0.3287	0.3583
Toxoplasma gondii	beta-1 tubulin, putative	0.0364	0.8075	1
Echinococcus granulosus	tubulin subunit beta	0.0364	0.8075	1
Schistosoma mansoni	tubulin subunit beta	0.0364	0.8075	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0364	0.8075	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0364	0.8075	1
Wolbachia endosymbiont of Brugia malayi	biotin-(acetyl-CoA carboxylase) ligase	0.0205	0.3921	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0236	0.4725	0.551
Plasmodium vivax	tubulin epsilon chain, putative	0.0181	0.3287	0.3583
Echinococcus multilocularis	Tubulin beta 2C chain	0.0364	0.8075	1
Echinococcus granulosus	tubulin alpha chain	0.0236	0.4725	0.551
Echinococcus granulosus	tubulin alpha	0.0181	0.3287	0.3583
Brugia malayi	Tubulin gamma chain	0.0181	0.3287	0.3583
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0364	0.8075	1
Giardia lamblia	Beta tubulin	0.0364	0.8075	1
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0236	0.4725	0.551
Leishmania major	beta tubulin	0.0364	0.8075	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0186	0.3419	0.3157
Mycobacterium leprae	POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS	0.0186	0.3425	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0133	0.2052	0.1927
Giardia lamblia	Gamma tubulin	0.0181	0.3287	0.3583
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Trypanosoma brucei	beta tubulin	0.0364	0.8075	1
Schistosoma mansoni	alpha tubulin	0.0236	0.4725	0.551
Echinococcus multilocularis	Tubulin beta 2C chain	0.0364	0.8075	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0236	0.4725	0.551
Echinococcus multilocularis	tubulin alpha 3 chain	0.0236	0.4725	0.551
Trypanosoma cruzi	Biotin--acetyl-CoA-carboxylase ligase, putative	0.0205	0.3921	0.4433
Echinococcus multilocularis	tubulin subunit beta	0.0364	0.8075	1
Echinococcus granulosus	tubulin epsilon chain	0.0181	0.3287	0.3583
Loa Loa (eye worm)	tubulin alpha 2	0.0157	0.2674	0.3311
Echinococcus granulosus	tubulin alpha chain	0.0236	0.4725	0.551
Trypanosoma brucei	beta tubulin	0.0181	0.3287	0.3583
Echinococcus multilocularis	tubulin alpha chain	0.0236	0.4725	0.551
Trypanosoma brucei	alpha tubulin	0.0236	0.4725	0.551
Leishmania major	alpha tubulin	0.0236	0.4725	0.551
Trypanosoma brucei	tubulin gamma chain	0.0181	0.3287	0.3583
Loa Loa (eye worm)	hypothetical protein	0.0236	0.4725	0.5851
Plasmodium falciparum	biotin protein ligase, putative	0.0205	0.3921	0.4433
Plasmodium vivax	tubulin alpha chain, putative	0.0236	0.4725	0.551
Entamoeba histolytica	tubulin alpha chain, putative	0.0236	0.4725	0.3004
Echinococcus multilocularis	biotin protein ligase	0.0205	0.3921	0.4433
Leishmania major	beta tubulin	0.0364	0.8075	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0102	0.1235	0.0833
Loa Loa (eye worm)	biotin protein ligase 1	0.0205	0.3921	0.4856
Echinococcus multilocularis	tubulin subunit TubB	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin beta chain, putative	0.0364	0.8075	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0181	0.3287	0.3583
Echinococcus multilocularis	tubulin alpha chain	0.0236	0.4725	0.551
Echinococcus granulosus	tubulin alpha 1C chain	0.0236	0.4725	0.551
Brugia malayi	tubulin alpha-2 chain	0.0236	0.4725	0.551
Toxoplasma gondii	alpha-tubulin I, putative	0.0236	0.4725	0.551
Leishmania major	beta tubulin	0.0364	0.8075	1
Trypanosoma brucei	alpha tubulin, putative	0.0102	0.1235	0.0833
Leishmania major	beta tubulin	0.0364	0.8075	1
Trypanosoma brucei	Biotin--acetyl-CoA-carboxylase ligase, putative	0.0205	0.3921	0.4433
Echinococcus granulosus	N terminal of biotin protein ligase	0.0186	0.3425	0.3767
Echinococcus granulosus	tubulin beta 1 chain	0.0364	0.8075	1
Loa Loa (eye worm)	tubulin beta chain	0.0078	0.0613	0.0759
Echinococcus granulosus	Tubulin alpha 1 chain	0.0236	0.4725	0.551
Loa Loa (eye worm)	tubulin alpha chain	0.0236	0.4725	0.5851
Echinococcus granulosus	tubulin subunit TubB	0.0236	0.4725	0.551
Trypanosoma cruzi	epsilon tubulin, putative	0.0181	0.3287	0.3583
Trypanosoma brucei	beta tubulin	0.0364	0.8075	1
Leishmania major	beta tubulin	0.0364	0.8075	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0236	0.4725	0.551
Trichomonas vaginalis	tubulin beta chain, putative	0.0102	0.1235	0.0833
Plasmodium falciparum	tubulin gamma chain	0.0181	0.3287	0.3583
Leishmania major	beta tubulin	0.0364	0.8075	1
Echinococcus granulosus	beta tubulin	0.0364	0.8075	1
Echinococcus multilocularis	tubulin alpha chain	0.0236	0.4725	0.551
Echinococcus granulosus	tubulin alpha 1C chain	0.0236	0.4725	0.551
Giardia lamblia	Alpha-tubulin	0.0236	0.4725	0.551
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2674	0.3311
Echinococcus multilocularis	tubulin alpha 1C chain	0.0236	0.4725	0.551
Trypanosoma cruzi	beta tubulin, putative	0.0364	0.8075	1
Schistosoma mansoni	tubulin subunit epsilon	0.0181	0.3287	0.3583
Echinococcus granulosus	beta tubulin	0.0364	0.8075	1
Loa Loa (eye worm)	tubulin beta chain	0.0364	0.8075	1
Echinococcus multilocularis	beta tubulin	0.0364	0.8075	1
Schistosoma mansoni	tubulin subunit gamma	0.0181	0.3287	0.3583
Schistosoma mansoni	tubulin subunit alpha	0.0236	0.4725	0.551
Plasmodium vivax	tubulin alpha chain, putative	0.0236	0.4725	0.551
Echinococcus granulosus	Tubulin alpha 1 chain	0.0236	0.4725	0.551
Schistosoma mansoni	tubulin subunit beta	0.0364	0.8075	1
Echinococcus multilocularis	hypothetical protein	0.0236	0.4725	0.551
Schistosoma mansoni	tubulin subunit beta	0.0364	0.8075	1
Trypanosoma brucei	alpha tubulin	0.0236	0.4725	0.551
Entamoeba histolytica	hypothetical protein, conserved	0.0186	0.3425	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0186	0.3425	0.4241

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1766339

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1513571