Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.2067 | 0.2067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.2067 | 0.2067 |
Entamoeba histolytica | cysteine protease, putative | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.2067 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0086 | 0.6495 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0058 | 0.2067 | 0.2067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0085 | 0.6314 | 0.5354 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.2067 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0086 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0086 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0086 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0086 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0058 | 0.2067 | 0.2067 |
Onchocerca volvulus | Cathepsin F homolog | 0.0086 | 0.6495 | 0.5582 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0058 | 0.2067 | 0.2067 |
Toxoplasma gondii | cathepsin CPL | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0086 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0058 | 0.2067 | 0.3182 |
Loa Loa (eye worm) | cysteine protease | 0.0086 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6495 | 0.5582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0086 | 0.6495 | 0.6495 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0086 | 0.6495 | 0.5582 |
Onchocerca volvulus | Cathepsin L homolog | 0.0086 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0086 | 0.6495 | 0.5582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0086 | 0.6495 | 0.6495 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0086 | 0.6495 | 0.6495 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0086 | 0.6495 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0058 | 0.2067 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 10 ug ml-1 | Cytotoxicity against human MCF7 cells assessed as cell growth after 2 days by sulforhodamine B assay | ChEMBL. | 21481593 |
GI50 (functional) | > 10 ug ml-1 | Cytotoxicity against human H460 cells assessed as cell growth after 2 days by sulforhodamine B assay | ChEMBL. | 21481593 |
GI50 (functional) | > 10 ug ml-1 | Cytotoxicity against human SF268 cells assessed as cell growth after 2 days by sulforhodamine B assay | ChEMBL. | 21481593 |
MFC (functional) | = 7.81 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 | ChEMBL. | 21481593 |
MFC (functional) | = 7.81 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 32264 | ChEMBL. | 21481593 |
MFC (functional) | = 15.63 ug ml-1 | Antifungal activity against Candida albicans ATCC 10213 | ChEMBL. | 21481593 |
MIC (functional) | = 3.9 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 | ChEMBL. | 21481593 |
MIC (functional) | = 7.81 ug ml-1 | Antifungal activity against Candida albicans ATCC 10213 | ChEMBL. | 21481593 |
MIC (functional) | = 7.81 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 32264 | ChEMBL. | 21481593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.