Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.3557 | 0.3557 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1611 | 0.1611 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0639 | 0.0639 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0639 | 0.0639 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.5122 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0639 | 0.0639 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.1611 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0639 | 0.0639 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.1611 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0639 | 0.0639 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.558 | 0.558 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1611 | 0.1611 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.558 | 0.558 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.3557 | 0.3557 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.558 | 0.558 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.6219 | 0.6219 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1611 | 0.1611 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.1611 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.1611 | 0.1611 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1611 | 0.1611 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0276 | 0.0276 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.5122 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4661 | 0.4661 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.558 | 0.558 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.1611 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.1611 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.6219 | 0.6219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.1 uM | Cytotoxicity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay | ChEMBL. | 21443218 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21443218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.