Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | No references |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TOPoisomerase family member | 0.0696 | 0.1338 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0483 | 0.0748 | 0.1791 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1722 | 0.4177 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0483 | 0.0748 | 0.1791 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0696 | 0.1338 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2979 | 0.7657 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0696 | 0.1338 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2979 | 0.7657 | 0.7657 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2979 | 0.7657 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1722 | 0.4177 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0483 | 0.0748 | 0.1791 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0696 | 0.1338 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0696 | 0.1338 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1953 | 0.4818 | 0.6292 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0696 | 0.1338 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1722 | 0.4177 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0696 | 0.1338 | 0.1747 |
Schistosoma mansoni | DNA topoisomerase II | 0.0696 | 0.1338 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2979 | 0.7657 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0696 | 0.1338 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2979 | 0.7657 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1722 | 0.4177 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0696 | 0.1338 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1025 | 0.225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.0748 | 0.5592 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0696 | 0.1338 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0603 | 0.1079 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0483 | 0.0748 | 0.1791 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1722 | 0.4177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.0748 | 0.5592 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2979 | 0.7657 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0696 | 0.1338 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0483 | 0.0748 | 0.1791 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0696 | 0.1338 | 0.3202 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0696 | 0.1338 | 0.1747 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0696 | 0.1338 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity | = 12.8 % | Cytotoxicity against mouse RAW264 | LITERATURE. | 27908762 |
Activity | = 40.8 % | Cytotoxicity against mouse RAW264 | LITERATURE. | 27908762 |
Activity | = 48.8 % | Cytotoxicity against mouse RAW264 | LITERATURE. | 27908762 |
Activity | = 82.4 % | Cytotoxicity against mouse RAW264 | LITERATURE. | 27908762 |
Activity | = 98.3 % | Cytotoxicity against mouse RAW264 | LITERATURE. | 27908762 |
IC50 (binding) | = 1.7 uM | Inhibition of BuChE (unknown origin) | ChEMBL. | No reference |
IC50 (binding) | = 146.1 uM | Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay | ChEMBL. | 21511472 |
Ki (binding) | = 3.1 uM | Inhibition of AChE (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.