Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0342 | 0.6433 | 0.6343 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0153 | 0.0244 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0342 | 0.6433 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Schistosoma mansoni | kinase | 0.0174 | 0.093 | 0.1108 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Giardia lamblia | Kinase, PLK | 0.0342 | 0.6433 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 0.4981 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0342 | 0.6433 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0342 | 0.6433 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0342 | 0.6433 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0342 | 0.6433 | 0.6343 |
Trypanosoma brucei | polo-like protein kinase | 0.0342 | 0.6433 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0342 | 0.6433 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0342 | 0.6433 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0342 | 0.6433 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.4981 | 0.743 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0342 | 0.6433 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.154 uM | Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting | ChEMBL. | 21470862 |
IC50 (functional) | = 0.598 uM | Antiproliferative activity against human A2780 cells | ChEMBL. | 21470862 |
IC50 (binding) | > 10 uM | Inhibition of PLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting | ChEMBL. | 21470862 |
IC50 (binding) | > 10 uM | Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting | ChEMBL. | 21470862 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21470862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.